{"id":2,"date":"2013-11-20T14:17:36","date_gmt":"2013-11-20T14:17:36","guid":{"rendered":"http:\/\/sites.lsa.umich.edu\/chapman-lab\/?page_id=2"},"modified":"2026-05-18T16:47:34","modified_gmt":"2026-05-18T16:47:34","slug":"sample-page","status":"publish","type":"page","link":"https:\/\/sites.lsa.umich.edu\/chapman-lab\/","title":{"rendered":"Welcome to the Chapman Lab"},"content":{"rendered":"\n<div class=\"wp-block-jetpack-slideshow aligncenter\" data-autoplay=\"true\" data-delay=\"5\" data-effect=\"slide\" style=\"--aspect-ratio:calc(489 \/ 380)\"><div class=\"wp-block-jetpack-slideshow_container swiper\"><ul class=\"wp-block-jetpack-slideshow_swiper-wrapper swiper-wrapper\"><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"489\" height=\"380\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-153\" data-id=\"153\" data-aspect-ratio=\"489 \/ 380\" src=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/Curliated-Bug.jpg\" srcset=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/Curliated-Bug.jpg 489w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/Curliated-Bug-300x233.jpg 300w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/Curliated-Bug-85x65.jpg 85w\" sizes=\"(max-width: 489px) 100vw, 489px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\"><i>E. coli<\/i> bacteria expressing the functional amyloid fiber, curli. <\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"489\" height=\"380\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-151\" data-id=\"151\" data-aspect-ratio=\"489 \/ 380\" src=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/Rdar1.jpg\" srcset=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/Rdar1.jpg 489w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/Rdar1-300x233.jpg 300w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/Rdar1-85x65.jpg 85w\" sizes=\"(max-width: 489px) 100vw, 489px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">Colony image showing curli-expressing cells in yellow. <\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"489\" height=\"380\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-32\" data-id=\"32\" data-aspect-ratio=\"489 \/ 380\" src=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/fpslide07full.jpg\" srcset=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/fpslide07full.jpg 489w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/fpslide07full-300x233.jpg 300w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/fpslide07full-85x65.jpg 85w\" sizes=\"(max-width: 489px) 100vw, 489px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">Purified CsgA protein forms amyloid fibers in vitro that are biochemically and structurally similar to curli fibers produced in vivo.<\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"572\" height=\"575\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-185\" data-id=\"185\" data-aspect-ratio=\"572 \/ 575\" src=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/Cover-for-Emma-copy-2.001.jpg\" srcset=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/Cover-for-Emma-copy-2.001.jpg 572w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/Cover-for-Emma-copy-2.001-298x300.jpg 298w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/Cover-for-Emma-copy-2.001-150x150.jpg 150w\" sizes=\"(max-width: 572px) 100vw, 572px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">2-Pryidones and Amyloid Formation&#8211; Fredrik Almqvist in Ume\u00e5 Sweden has developed a library of peptidomimetic compounds that can be potent amyloid modifiers. We are using these 2-pyridone molecules as tools to better understand amyloid formation, and also as inhibitors of amyloid-dependent bacterial processes such as biofilm formation.  <\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"489\" height=\"380\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-43\" data-id=\"43\" data-aspect-ratio=\"489 \/ 380\" src=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/fpslide03full.jpg\" srcset=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/fpslide03full.jpg 489w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/fpslide03full-300x233.jpg 300w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/fpslide03full-85x65.jpg 85w\" sizes=\"(max-width: 489px) 100vw, 489px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">High-resolution EM analysis of purified CsgG-his protein reveals donut-shaped structures approximately 15 nM in diameter. <\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"489\" height=\"380\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-42\" data-id=\"42\" data-aspect-ratio=\"489 \/ 380\" src=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/fpslide04full.jpg\" srcset=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/fpslide04full.jpg 489w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/fpslide04full-300x233.jpg 300w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/fpslide04full-85x65.jpg 85w\" sizes=\"(max-width: 489px) 100vw, 489px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">Negative-stain electron microscopy shows that curli are 4-7-nm wide fibers of varying lengths.<\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"2136\" height=\"1386\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-144\" data-id=\"144\" data-aspect-ratio=\"1024 \/ 664\" src=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/red_blue2.png\" srcset=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/red_blue2.png 2136w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/red_blue2-300x195.png 300w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/red_blue2-1024x664.png 1024w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/red_blue2-768x498.png 768w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/red_blue2-1536x997.png 1536w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/red_blue2-2048x1329.png 2048w\" sizes=\"(max-width: 2136px) 100vw, 2136px\" \/><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"489\" height=\"380\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-225\" data-id=\"225\" data-aspect-ratio=\"489 \/ 380\" src=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/Dan-lab1.jpg\" srcset=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/Dan-lab1.jpg 489w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/Dan-lab1-300x233.jpg 300w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/Dan-lab1-85x65.jpg 85w\" sizes=\"(max-width: 489px) 100vw, 489px\" \/><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"489\" height=\"380\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-154\" data-id=\"154\" data-aspect-ratio=\"489 \/ 380\" src=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/biofilm-matrix.jpg\" srcset=\"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/biofilm-matrix.jpg 489w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/biofilm-matrix-300x233.jpg 300w, https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-content\/uploads\/sites\/25\/2014\/05\/biofilm-matrix-85x65.jpg 85w\" sizes=\"(max-width: 489px) 100vw, 489px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">Freeze-fracture, deep-etch electron micrograph showing colonies of curliated <i>E. coli<\/i> after 48 hours of growth. Curli fibers surround and connect individual bacteria into small groups.<\/figcaption><\/figure><\/li><\/ul><a class=\"wp-block-jetpack-slideshow_button-prev swiper-button-prev swiper-button-white\" role=\"button\"><\/a><a class=\"wp-block-jetpack-slideshow_button-next swiper-button-next swiper-button-white\" role=\"button\"><\/a><a aria-label=\"Pause Slideshow\" class=\"wp-block-jetpack-slideshow_button-pause\" role=\"button\"><\/a><div class=\"wp-block-jetpack-slideshow_pagination swiper-pagination swiper-pagination-white\"><\/div><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Curli are extracellular organelles produced by <em>Escherichia coli<\/em> and certain <em>Salmonella<\/em> species. These fibers are structurally and biochemically identical to eukaryotic amyloid fibers, which underlie diverse mammalian ailments including Alzheimer&#8217;s disease (AD), systemic amyloidosis, bovine spongiform encephalopathy (mad cow disease), and Creutzfeldt-Jacob disease, among others.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The Chapman lab uses the curli system to study the fundamental principles of amyloid formation. We continue to dissect the biogenesis of curli fibers, as well as the consequences of curli amyloid formation on the biology of microbial communities.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Follow us on&nbsp;<a href=\"https:\/\/twitter.com\/Chapman_Lab\">Twitter<\/a>&nbsp;@Chapman_lab and&nbsp;<a href=\"https:\/\/www.instagram.com\/chapman_lab\/\">Instagram<\/a>&nbsp;@chapman_lab!<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Curli are extracellular organelles produced by Escherichia coli and certain Salmonella species. These fibers are structurally and biochemically identical to eukaryotic amyloid fibers, which underlie diverse mammalian ailments including Alzheimer&#8217;s disease (AD), systemic amyloidosis, bovine spongiform encephalopathy (mad cow disease), and Creutzfeldt-Jacob disease, among others. The Chapman lab uses the curli system to study the [&hellip;]<\/p>\n","protected":false},"author":44,"featured_media":547,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2","page","type-page","status-publish","has-post-thumbnail","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-json\/wp\/v2\/pages\/2","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-json\/wp\/v2\/users\/44"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":10,"href":"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":777,"href":"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-json\/wp\/v2\/pages\/2\/revisions\/777"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-json\/wp\/v2\/media\/547"}],"wp:attachment":[{"href":"https:\/\/sites.lsa.umich.edu\/chapman-lab\/wp-json\/wp\/v2\/media?parent=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}