Lactase Persistence and the Extended Evolutionary Synthesis: A Beneficial Framework for Studies of Human Evolution

References

Baedke, J., Fábregas-Tejeda, A., & Vergara-Silva, F. (2020). Does the extended evolutionary synthesis
entail extended explanatory power? Biology & Philosophy, 35, 1–22. doi:10.1007/
s10539-020-9736-5

Beatty, J. (1986). The synthesis and the synthetic theory. In W. Bechtel (Ed.), Integrating Scientific
Disciplines (pp. 125–135). doi:10.1007/978-94-010-9435-1

Brandon, R. (1986). Introduction. In W. Bechtel (Ed.), Integrating Scientific Disciplines (pp. 109–111).
doi:10.1007/978-94-010-9435-1

Breton, G., Schlebusch, C. M., Lombard, M., Sjödin, P., Soodyall, H., & Jakobsson, M. (2014). Lactase
persistence alleles reveal partial East African ancestry of Southern African Khoe pastoralists.
Current Biology, 24, 852–858. doi:10.1016/j.cub.2014.02.041

Campbell, M. C., & Ranciaro, A. (2021). Human adaptation, demography and cattle domestication: An
overview of the complexity of lactase persistence in Africa. Human Molecular Genetics,
30(R1), R98–109. doi:10.1093/hmg/ddab027

Colegrave, N., & Collins, S. (2008). Experimental evolution: Experimental evolution and evolvability.
Heredity, 100, 464–470. doi:10.1038/sj.hdy.6801095

Craig, L. R. (2010). The so-called extended synthesis and population genetics. Biological Theory, 5,
117–123. doi:10.1162/BIOT_a_00035

Danchin, E., Charmantier, A., Champagne, F. A., Mesoudi, A., Pujol, B., & Blanchet, S. (2011). Beyond
DNA: Integrating inclusive inheritance into an extended theory of evolution. Nature Reviews
Genetics, 12, 475–486. doi:10.1038/nrg3028

Darden, L. (1986). Relations among fields in the evolutionary synthesis. In W. Bechtel (Ed.),
Integrating Scientific Disciplines (pp. 113–123). doi:10.1007/978-94-010-9435-1

Dickins, T. E., & Rahman, Q. (2012). The extended evolutionary synthesis and the role of soft
inheritance in evolution. Proceedings of the Royal Society B: Biological Sciences, 279, 2913–2921. doi:10.1098/rspb.2012.0273

Dunning Hotopp, J. C. (2011). Horizontal gene transfer between bacteria and animals. Trends in
Genetics, 27(4), 157–163. doi:10.1016/j.tig.2011.01.005

Fuentes, A. (2016). The extended evolutionary synthesis, ethnography, and the human niche: Toward
an integrated anthropology. Current Anthropology, 57, S13–S26. doi:10.1086/685684

Futuyma, D. J. (2017). Evolutionary biology today and the call for an extended synthesis. Interface
Focus, 7, 1–13. doi:10.1098/rsfs.2016.0145

Gerbault, P. (2013). The onset of lactase persistence in Europe. Human Heredity, 76, 154–161.
doi:10.1159/000360136

Gerbault, P., Liebert, A., Itan, Y., Powell, A., Currat, M., Burger, J., … Thomas, M. G. (2011). Evolution
of lactase persistence: An example of human niche construction. Philosophical Transactions
of the Royal Society B: Biological Sciences, 366, 863–877. doi:10.1098/rstb.2010.0268

Gilbert, S. F., Opitz, J. M., & Raff, R. A. (1996). Resynthesizing evolutionary and developmental
biology. Developmental Biology, 173, 357–372. doi:10.1006/dbio.1996.0032

Goodnight, C. (2012). On multilevel selection and kin selection: Contextual analysis meets direct
fitness. Evolution, 67, 1539–1548. doi:10.1111/j.1558-5646.2012.01821.x

Hall, B. K. (2012). Evolutionary developmental biology (evo-devo): Past, present, and future.
Evolution: Education and Outreach, 5, 184–193. doi:10.1007/s12052-012-0418-x

Harvey, C. B., Fox, M. F., Jeggo, P. A., Mantei, N., Povey, S., & Swallow, D. M. (1993). Regional
localization of the lactase-phlorizin hydrolase gene, LCT, to chromosome 2q21. Annals of
Human Genetics, 57(3), 179–185. doi:10.1111/j.1469-1809.1993.tb01593.x

Huxley, J. (1942). Evolution: The Modern Synthesis. London, UK: Allen & Unwin.

Jablonka, E., & Lamb, M. J. (2008). Soft inheritance: Challenging the modern synthesis. Genetics and
Molecular Biology, 31, 389–395. doi:10.1590/S1415-47572008000300001

Jeong, C., & Di Renzo, A. (2014). Adaptations to local environments in modern human populations.
Current Opinion in Genetics & Development, 29, 1–8. doi:10.1016/j.gde.2014.06.011

Keeling, P. J., & Palmer, J. D. (2008). Horizontal gene transfer in eukaryotic evolution. Nature Reviews
Genetics, 9, 605–618. doi:10.1038/nrg2386

Kirschner, M., & Gerhart, J. (1998). Evolvability. Proceedings of the National Academy of Sciences of
the United States of America, 95, 8420–8427. doi:10.1073/pnas.95.15.8420

Kissel, M., & Fuentes, A. (2021). The ripples of modernity: How we can extend paleoanthropology
with the extended evolutionary synthesis. Evolutionary Anthropology, 30, 84–98.
doi:10.1002/evan.21883

Labrie, V., Buske, O. J., Oh, E., Jeremian, R., Ptak, C., Gasiūnas, G., … Petronis, A. (2016). Lactase
nonpersistence is directed by DNA-variation-dependent epigenetic aging. Nature Structural
& Molecular Biology, 23, 566–573. doi:10.1038/nsmb.3227

Laland, K. N., & Boogert, N. J. (2010). Niche construction, co-evolution and biodiversity. Ecological
Economics, 69, 731–736. doi:10.1016/j.ecolecon.2008.11.014

Laland, K. N., Toyokawa, W., & Oudman, T. (2019). Animal learning as a source of developmental bias.
Evolution & Development, 22, 126–142. doi:10.1111/ede.12311

Laland, K. N., Uller, T., Feldman, M., Sterelny, K., Müller, G. B., Moczek, A., … Strassman, J. E. (2014).
Does evolutionary theory need a rethink? Nature, 514, 161–164. doi:10.1038/514161a

Leseva, M. N., Grand, R. J., Klett, H., Boerries, M., Busch, H., Binder, A. M., & Michels, K. B. (2018). Differences in DNA methylation and functional expression in lactase persistent and non-
persistent individuals. Scientific Reports, 8, 1–14. doi:10.1038/s41598-018-23957-4

Lewens, T. (2017). Human nature, human culture: The case of cultural evolution. Interface Focus,
7(5), 1–7. doi:10.1098/rsfs.2017.0018

Lewens, T. (2019). The extended evolutionary synthesis: What is the debate about, and what might
success for the extenders look like? Biological Journal of the Linnean Society, 127, 707–721.
doi:10.1093/biolinnean/blz064

Lewinsky, R. H., Jensen, T. G. K., Møller, J., Stensballe, A., Olsen, J., & Troelsen, J. T. (2005). T−13910 DNA
variant associated with lactase persistence interacts with Oct-1 and stimulates lactase
promoter activity in vitro. Human Molecular Genetics, 14, 3945–3953. doi:10.1093/hmg/
ddi418

Liebert, A., López, S., Jones, B. L., Montalva, N., Gerbault, P., Lau, W., … Swallow, D. M. (2017). World-
wide distributions of lactase persistence alleles and the complex effects of recombination and selection. Human Genetics, 136, 1445–1453. doi:10.1007/s00439-017-1847-y

Lockhart, D. J., & Winzeler, E. A. (2000). Genomics, gene expression and DNA arrays. Nature, 405,
827–836. doi:10.1038/35015701

Mantei, N., Villa, M., Enzler, T., Wacker, H., Boll, W., James, P., … Semenza, G. (1988). Complete
primary structure of human and rabbit lactase-phlorizin hydrolase: Implications for
biosynthesis, membrane anchoring and evolution of the enzyme. The EMBO Journal, 7,
2705–2713. doi:10.1002/j.1460-2075.1988.tb03124.x

Matthews, B., De Meester, L., Jones, C. G., Ibelings, B. W., Bouma, T. J., Nuutinene, V., … Odling-Smee,
J. (2014). Under niche construction: An operational bridge between ecology, evolution, and
ecosystem science. Ecological Monographs, 84, 245–263. doi:10.1890/13-0953.1

Mayr, E. (1993). What was the evolutionary synthesis? Trends in Ecology and Evolution, 8(1), 31–34.
doi:10.1016/0169-5347(93)90128-C

Moeller, A. H., & Sanders, J. G. (2020). Roles of the gut microbiota in the adaptive evolution of
mammalian species. Philosophical Transactions of the Royal Society B: Biological Sciences,
375, 1–10. doi:10.1098/rstb.2019.0597

Müller, G. B. (2007). Evo–devo: Extending the evolutionary synthesis. Nature Reviews Genetics, 8,
943–949. doi:10.1038/nrg2219

Müller, G. B. (2017). Why an extended evolutionary synthesis is necessary. Interface Focus, 7(5), 1 doi:10.1098/rsfs.2017.0015

Murray, J. K., Benitez, R. A., & O’Brien, M. J. (2021). The extended evolutionary synthesis and human
origins: Archaeological perspectives. Evolutionary Anthropology, 30, 4–7. doi:10.1002/
evan.21837

Newitz, A. (2021). The origin of home. Scientific American, 324(3), 66–71. doi:10.1038/
scientificamerican0321-66

Noble, D. (2015). Evolution beyond neo-Darwinism: A new conceptual framework. Journal of
Experimental Biology, 218, 7–13. doi:10.1242/jeb.106310

O’Brien, M. J., & Bentley, R. A. (2021). Genes, culture, and the human niche: An overview.
Evolutionary Anthropology, 30, 40–49. doi:10.1002/evan.21865

Ochman, H., Lawrence, J. G., & Groisman, E. A. (2000). Lateral gene transfer and the nature of
bacterial innovation. Nature, 405, 299–304. doi:10.1038/35012500

Odling-Smee, F. J., Laland, K. N., & Feldman, M. W. (1996). Niche construction. The American
Naturalist, 147, 641–648. Retrieved from https://www.jstor.org/stable/2463239

Pigliucci, Massimo. (2007). Do we need an extended evolutionary synthesis? Evolution, 61, 2743–2749 doi:10.1111/j.1558-5646.2007.00246.x

Pigliucii, M. (2008). Is evolvability evolvable? Nature Reviews Genetics, 9, 75–82. doi:10.1038/
nrg2278

Price, T. D., Qvarnström, A., & Irwin, D. E. (2003). The role of phenotypic plasticity in driving genetic
evolution. Proceedings of the Royal Society B: Biological Sciences, 270, 1433–1440.
doi:10.1098/rspb.2003.2372

Reece, J. B., Meyers, N., Urry, L. A., Cain, M. L., Wasserman, S. A., Minorsky, P. V., … Cooke, B. N.
(2015). Campbell Biology: Australian and New Zealand Version (10th ed.). Melbourne,
Australia: Pearson Australia.

Roth, S. C. (2019). What is genomic medicine? Journal of the Medical Library Association, 107, 442–448 doi:10.5195/jmla.2019.604

Schlebusch, C. M., Sjödin, P., Skoglund, P., & Jakobsson, M. (2013). Stronger signal of recent selection
for lactase persistence in Maasai than in Europeans. European Journal of Human Genetics,
21, 550–553. doi:10.1038/ejhg.2012.199

Schultheis, P. J., & Bowling, B. V. (2011). Analysis of a SNP linked to lactase persistence: An exercise
for teaching molecular biology techniques to undergraduates. Biochemistry and Molecular
Biology Education, 39, 133–140. doi:10.1002/bmb.20456

Swallow, D. M., & Troelsen, J. T. (2016). Escape from epigenetic silencing of lactase expression is
triggered by a single-nucleotide change. Nature Structural & Molecular Biology, 23, 505–507.
doi:10.1038/nsmb.3238

Tavassoly, I., Goldfarb, J., & Iyengar, R. (2018). Systems biology primer: The basic methods and
approaches. Essays in Biochemistry, 62, 487–500. doi:10.1042/EBC20180003

Tishkoff, S. A., Reed, F. A., Ranciaro, A., Voight, B. F., Babbitt, C. C., Silverman, J. S., … Deloukas, P.
(2006). Convergent adaptation of human lactase persistence in Africa and Europe. Nature
Genetics, 39, 31–40. doi:10.1038/ng1946

Vesa, T. H., Marteau, P., & Korpela, R. (2000). Lactose intolerance. Journal of the American College of
Nutrition, 19, 165S–175S. doi:10.1080/07315724.2000.10718086

Vicente, M., Priehodová, E., Diallo, I., Podgorná, E., Poloni, E. S., Černý, V., & Schlebusch, C. M. (2019) Population history and genetic adaptation of the Fulani nomads: Inferences from genome-
wide data and the lactase persistence trait. BMC Genomics, 20, 1–12. doi:10.1186/s12864-019-6296-7

Wells, D. A. (2021). Plasticity-led evolution and human culture. Integrative Psychological and
Behavioral Science. Advance online publication. doi:10.1007/s12124-021-09607-x

Wells, J. C. K., & Stock, J. T. (2011). Re-examining heritability: Genetics, life history and plasticity.
Trends in Endocrinology & Metabolism, 22, 421–428. doi:10.1016/j.tem.2011.05.006

West-Eberhard, M. J. (1989). Phenotypic plasticity and the origins of diversity. Annual Review of
Ecology and Systematics, 20, 249–278. doi:10.1146/annurev.es.20.110189.001341

Whitfield, J. (2008). Biological theory: Postmodern evolution? Nature, 455, 281–284.
doi:10.1038/455281a

lsa logoum logoU-M Privacy StatementAccessibility at U-M
Scroll to Top