{"id":9,"date":"2020-07-23T13:55:26","date_gmt":"2020-07-23T13:55:26","guid":{"rendered":"http:\/\/sites.lsa.umich.edu\/haoxingx\/?page_id=9"},"modified":"2021-12-29T22:01:09","modified_gmt":"2021-12-29T22:01:09","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.lsa.umich.edu\/haoxingx\/publications\/","title":{"rendered":"Lab Publications"},"content":{"rendered":"\n

(2007- present; after moving to Michigan; featured publications in red<\/span>)<\/p>\n\n\n\n

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1. Du, W.<\/strong>, Gu, M.<\/strong>, Hu, M.<\/strong>, Pinchi, P.<\/strong>, Chen, W.<\/strong>, Ryan., M, Nold, T., Bannaga, A.,<\/strong> and Xu H<\/strong> (2021). Lysosomal release triggers mitochondria-mediated non-apoptotic cell death in metastatic melanoma. Cell Reports<\/em><\/u><\/em><\/em> <\/em> (in press)<\/em>.<\/span><\/p>\n\n\n\n

2. Yue, L, and Xu H <\/strong>(2021).  TRP channels in health and disease at a glance. J. Cell Sci.<\/em><\/u><\/em><\/span><\/em> <\/u><\/em> 2021 Jul 1;134(13):jcs258372. doi: 10.1242\/jcs.258372. Epub 2021 Jul 13.<\/p>\n\n\n\n

3. Zhang W, Yang X, Chen L, Liu YY, Venkatarangan V, Reist L, Hanson P, Xu H<\/strong>, Wang Y, Li M (2021). A conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation. PloS Biol.<\/em><\/u><\/em> <\/span> <\/em>2021 Jul 23;19(7):e3001361. doi: 10.1371\/journal.pbio.3001361. <\/p>\n\n\n\n

4. <\/span><\/strong>Li, P<\/strong>., Hu, M.<\/strong> *, Wang, C.<\/strong> *, Feng, X., Zhao, Z., Yang, Y.<\/strong>, Sahoo, N.<\/strong>, Gu, M.<\/strong>, Xiao, S.,<\/strong> Sah, R., Cover, T., Geha, R., and Xu H <\/strong>(2020).  An osmo-sensitive ion channel in the lysosome.  PNAS<\/u><\/em>  2020 Nov 17;117(46):29155-29165.<\/span><\/a><\/a><\/em><\/p>\n\n\n\n

5.Li, D<\/strong>., Shao, R.<\/strong>, Wang, N<\/strong>., Zhang, X.<\/strong>, and Xu H <\/strong>(2020) a lysosome-dependent transcriptional program to mitigate oxidative Stress.   Autophagy<\/em><\/u><\/em><\/span><\/em> 2020 Mar 15;1-16. doi: 10.1080\/15548627.2020.1739442. <\/p>\n\n\n\n

6. Yu, L., Zhang, X., Yang, Y., Li, D., Tang, K., He., W, Wang, C., Sahoo, N<\/strong>., Davis, C., Brooks, S.  Bigot, A., Calvo., R., Marugan, J., Ferrer, M., and Xu H <\/strong>(2020).  Small molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models. Science Advances<\/u><\/em>  2020, Feb 7;6(6):eaaz2736. doi: 10.1126\/sciadv.aaz2736.<\/p>\n\n\n\n

7. Zhang, X<\/strong>. *, Chen, W. *, Li, P. *<\/strong>, Calvo, R., Southall, N., Hu, X., Feng, X., Geng, Q., Gao, C., Yang, M., Tang<\/strong>, K.,  Ferrer, M., Marugan, J., and Xu H <\/strong>(2019).  Agonist-specific Voltage-dependent Gating of Lysosomal Two-pore Na+ Channels. <\/span>eLife. <\/a><\/u><\/em>PDF<\/a>.     <\/p>\n\n\n\n

8. Minckley T., Zhang, C., Fudge, D., Dischler, A., LeJeune, K.,Xu H and, Qin, Y<\/strong>. (2019). Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals . Nature Communications.<\/em> 2019 Oct 22;10(1):4806. doi: 10.1038\/s41467-019-12761-x.<\/p>\n\n\n\n

9. Zhang X., Gu, M., Hu, M., Yang, Y.,and Xu H<\/strong> (2019).Endosomal and lysosomal electrophysiology. “Ion and Molecule Transport in Lysosomes” Book—CRC Methods in Signaling Transduction Series (in press).<\/em><\/p>\n\n\n\n

10.Xin, Y., Malick, A., Hu, M.,<\/strong>,Liu, C., Batah, H., Xu, H<\/strong>. and, Duan C., (2019). Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6 . eLife<\/em>. Sep 17;8. pii: e48003. doi: 10.7554\/eLife.48003. [Epub ahead of print]<\/p>\n\n\n\n

11. Zhang, X<\/strong>., Chen., W<\/strong>., Gao, Q., Yang, J., Yan, X., <\/strong>Zhao., H,., Lin, S., Yang, M., Chen, G., <\/strong>Yao,. Y, Inoki, K, Li, D. Shao, R., Wang, S., Sahoo, N., <\/strong>Kudo, F., Egguchi, T., Ruan, B.,and, Xu H<\/strong> (2019). Rapamycin Directly Activates Lysosomal Mucolipin TRP Channels Independent of mTOR. PloS Biol.<\/em><\/u> <\/em>May 21;17(5):e3000252. doi: 10.1371\/journal.pbio.3000252. eCollection 2019 May. PDF<\/a><\/span><\/a><\/em><\/p>\n\n\n\n

11. Li, P<\/strong>., Gu, M<\/strong>., and, Xu H<\/strong> (2018). Lysosomal Ion Channels As Decoders of Cellular Signals. Trends in Biochemical Sciences. <\/em>Feb;44(2):110-124. doi: 10.1016\/j.tibs.2018.10.006. Epub 2018 Nov 10.<\/span> PDF<\/a><\/a><\/em><\/p>\n\n\n\n

12. Zhang, X<\/strong>., Hu, M<\/strong>., Yang, Y<\/strong>.,and, Xu H<\/strong> (2018).Organellar TRP Channels . Nat. Struct. Mol. Biol. <\/em>Nov;25(11):1009-1018. doi: 10.1038\/s41594-018-0148-z. Epub 2018 Oct 29.<\/span> PDF<\/a><\/a><\/em><\/p>\n\n\n\n

13.Wang, Z., Ocadiz-Ruiz, R., Sundaresan, S., Ding, L., Hayes, M., Sahoo, N., , Xu, H.<\/strong>, and, Merchant JL(2018). Isolation of enteric glial cells from the submucosa and lamina propria of the adult mouse . J. Vis. Exp. <\/em>2018 Aug 15;(138). doi: 10.3791\/57629.<\/p>\n\n\n\n

14 .Yang, J<\/strong>., Zhao., Z., Gu, M.<\/strong>, Feng, X., and, Xu H<\/strong> (2018). Release and uptake mechanisms of vesicular Ca2+ stores . Protein & Cell <\/em>Mar 16. doi: 10.1007\/s13238-018-0523-x.<\/p>\n\n\n\n

15. Chen Q, She J, Zeng W, Guo J, Xu H<\/strong>, Bai XC, Jiang Y. Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature<\/u><\/em>. 2017 Oct 11. doi: 10.1038\/nature24035. [Epub ahead of print].<\/span><\/p>\n\n\n\n

16. Sundaresan S, Meininger CA, Kang AJ, Photenhauer AL, Hayes MM, Sahoo N<\/strong>, Grembecka J, Cierpicki T, Ding L, Giordano TJ, Else T, Madrigal DJ, Low MJ, Campbell F, Baker AM, Xu H<\/strong>, Wright NA, Merchant JL. Gastroenterology <\/em>( 2017). Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells. Aug 28. pii: S0016-5085(17)36071-7. doi: 10.1053\/j.gastro.2017.08.038. [Epub ahead of print]<\/p>\n\n\n\n

17 Sahoo, N., Gu, M., Zhang, X., Raval, N., Yang, J<\/strong>., Bekier, M., Calvo, R.,Patnaik, S., Wang, W., King, G., Samie, M., Gao, Q., Sahoo, S<\/strong>., Sundaresan, S., Kelly, T., Wang, Y., Marugan, J., Ferrer, M., Samuelson, L., Merchant, J., and Xu, H.  <\/strong>(2017). A Ca(2+) efflux channel in the tubolovesicle.  Developmental Cell<\/u><\/em>. 2017 May 8;41(3):262-273.e6. doi: 10.1016\/j.devcel.2017.04.003. <\/span>PDF <\/a><\/a><\/em><\/p>\n\n\n\n

18.<\/span><\/strong> Wang, W., Zhang, X., Gao, Q., Cheng, X., Lawas, M., Sahoo N.<\/strong>, Meredith M., and Xu, H.<\/strong> (2017). A K+ channel in the lysosome is required for store refilling.  J. Cell<\/u><\/em>. Biol.<\/em>  May 3. pii: jcb.201612123. doi: 10.1083\/jcb.201612123. [Epub ahead of print]. PDF<\/a><\/span><\/a><\/em><\/p>\n\n\n\n

19. <\/strong>Hirano, T., Stecker, K., Munnik, T., Xu, H., <\/strong>and Sato M.  (2017) Plant and Cell Physiology. <\/em>. Visualization of phosphatidylinositol 3,5-bisphosphate dynamics by tandem ML1N-based fluorescent protein probe in Arabidopsis. 2017 Jan 31. doi: 10.1093\/pcp\/pcx011<\/p>\n\n\n\n

20 Gu, M<\/strong>., and Xu, H.<\/strong>  (2016) Journal of Cell Biology<\/em>. A painful TR(i)P to lysosomes. Nov 7;215(3):309-312 . PDF<\/a><\/a><\/em><\/p>\n\n\n\n

21 <\/strong>Krishna, S., Palm, W., Lee, Y., Yang, W.,  Bandyopadhyay, U., Xu, H.<\/strong>,  Oliver Florey, O,  Thompson, C, and  Overholtzer, M.. (2016) Dev. Cell<\/em>. PIKfyve regulates vacuole maturation and nutrient recovery following engulfment. Sep 12;38(5):536-47. doi: 10.1016\/j.devcel.2016.08.001.<\/p>\n\n\n\n

22. Zhang, X<\/strong>., Lu, Yu, <\/strong>and Xu, H.<\/strong> (2016). Lysosome Calcium in ROS Regulation of Autophagy.. Autophagy<\/em>Oct 2;12(10):1954-1955. PDF<\/a><\/a><\/em><\/p>\n\n\n\n

23. Garrity, A., Wang, X, Collier C.M.D, Levey, S.A., Gao, Q.,<\/strong> and Xu, H.<\/strong> (2016). The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes. eLife<\/em>2016 May 23;5. pii: e15887. doi: 10.7554\/eLife.15887.<\/span> PDF<\/a><\/a><\/em><\/p>\n\n\n\n

24. Zhang, X.<\/strong>, Cheng, X<\/strong>., Yu, L<\/strong>., Yang, J<\/strong>., Calvo, R., Patnaik, S., Hu, X., Gao, Q<\/strong>., Yang, M<\/strong>., Lawas, M<\/strong>.,Delling, M., Marugan, J., Ferrer, M., and Xu, H. <\/strong>(2016) ROS sensor in lysosomes that regulates autophagy. Nature Communications.<\/em> 2016 Jun 30;7:12109. doi: 10.1038\/ncomms12109.<\/span> PDF<\/a><\/a><\/em><\/p>\n\n\n\n

25. Li.X., Rydzewski, N., Hider., A., Zhang, X., Yang, J., Wang. W., Gao., Cheng., X., <\/strong>and Xu, H.<\/strong> . (2016) A Molecular Mechanism to regulate lysosome positioning. Nat. Cell. Biol. 2016.<\/em><\/span>  <\/em>PDF<\/a><\/a><\/em><\/p>\n\n\n\n

26. Cheng., X., Zhang, X., Yu, L., <\/strong>and Xu, H.<\/strong> . (2015) Ca2+ signaling in membrane repair. Seminars in Cell and Developmental Biology(invited review). <\/em>2015 Sep; 45;24-3. <\/em> <\/p>\n\n\n\n

27. Miao Y., Li, G., Zhang, X., Xu, H.<\/strong>, and Abraham SN. (2015) A TRP channel senses lysosome neutralization by pathogens to trigger their expulsion. Cell.<\/em> 2015 Jun 4;161(6):1306-19. <\/p>\n\n\n\n

28 Xu, H.<\/strong>, Martinoia E., and Szabo I. (2015) Organellar Channels and Transporters. Cell Calcium. 2015 Jul 1;58(1):1-10.<\/em> PDF<\/a><\/a><\/em><\/p>\n\n\n\n

29. Wang, W., Gao, Q., Yang, M., Zhang, X., Yu, L., Lawas, M., Li, X<\/strong>., Bryant-Genevier, M., Southall, N., Marugan, J., Ferrer, M., and Xu, H.<\/strong> (2015). TRPML1 channels in lysosomal adaptation to nutrient starvation.  PNAS Plus<\/em>. <\/a> <\/em>PDF<\/a><\/p>\n\n\n\n

30. Medina, L.M., Di Paola, S., Peluso, I., Armani, A., De Stefani, D., Ventiti, R., Montefusco, S., Scotto-Rosata, A., Presioso, C., Forrester, A., Settermbre, C., Wang, W., Gao, Q.<\/strong>, Xu, H.<\/strong>, Sandri, M., Rizzuto, R., De Matteis, M., and Ballabio. (2015). Lysosomal calcium signaling regulates autophagy .  Nat. Cell. Biol.<\/em> 2015 Mar;17(3):288-99.<\/p>\n\n\n\n

31.  Xu, H <\/strong>and Ren D. (2015) Lysosomal Physiology. Annual Review in Physiology. 2015 Feb. 10; 77: 57-80<\/em><\/span> <\/a> <\/em>PDF<\/a><\/p>\n\n\n\n

32. Qiong G., Zhang X., <\/strong>and Xu, H<\/strong> (2014). TRPML channels: Handbook of Ion channels.in press<\/em>.<\/p>\n\n\n\n

33.Cheng, X., Zhang, X., Gao, Q., Azar, M., Tsang, W.L., Dong, L., Samie, M., Li, X., Zhuo, Y., Garrity, A., Wang, X<\/strong>., Ferrer, M., Dowling, J., Xu, L., Han, R., and Xu, H<\/strong>. (2014) An Intracellular Ca2+ Channel is Required For Sarcolemma Repair to Prevent Muscular Dystrophy. Nature Medicine.<\/em> Epub Sept. 14<\/span> <\/a>  PDF<\/a><\/p>\n\n\n\n

34 Bae M, Patel N, Xu H,<\/strong> Lee M, Nath A, Geiger J, Gorospe M, Mattson MP, and Haughey NJ ( 2014). Activation of TRPML1 clears intraneuronal A\u03b2 in preclinical Models of HIV infection. Journal of Neurosceicne. Aug. 20; 34(34): 11485-503.<\/em><\/p>\n\n\n\n

35. Samie, M.<\/strong>, and Xu, H<\/strong>. (2014) Lysosomal exocytosis and lipid storage disorders. Journal of Lipid Research (Invited review). March 25; 55. <\/em><\/a> PDF<\/a><\/p>\n\n\n\n

36. Sun Y., Yong K., Villa-Diaz, L, Zhang, X.<\/strong>, Chen, W., Philson, R., Weng, S., Xu H<\/strong>., Krebsbach,P., and Fu, J (2014). Hippo\/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells. Nature Materials (2014). Jun. 599-604<\/em><\/p>\n\n\n\n

37. Li, X., Wang, X. , Zhang, X. Tsang, W.L, ,Zhao, M., <\/strong>Zhang, Y., Yau R.W., Weisman, LS., and  Xu, H<\/strong>. (2013) A Genetically-encoded Fluorescent probe to visulize intracellualr PI(3,5)P2 localization and dynamics. PNAS <\/em>(Epub 2013 Dec. 11). <\/a> PDF<\/a><\/p>\n\n\n\n

38 Samie, M., Wang, X. , Zhang, X. ,Goschka, A.,Li, X., Cheng, X., Gregg, E., Azar, M., Zhuo, Y., Garrity, AG,<\/strong>,Gao, Q<\/strong>., Slaugnehaupt, S, Pickel, J., Zolov, S., Weisman, LS., Lenk, G., Titus, S., Bryant-Genevier, M., Southall, N., Juan, M., Ferrer, M., and  Xu, H<\/strong>. (2013) A TRP channel in the lysosome regulates focal exocytosis.  Developmental Cell. <\/em>Sep 16;26(5):511-24. doi: 10.1016\/j.devcel.2013.08.003. Epub 2013 Aug 29.).  <\/span> PDF<\/a><\/a><\/p>\n\n\n\n

39. Wang W., Zhang, X., Gao, Q., <\/strong>and Xu, H<\/strong>. (2013) TRPML1: an ion channel in the Lysosome. Handbook of Experimental Pharmacology HEP. <\/em>222:631-45..<\/p>\n\n\n\n

40. Li, X., Garrity A.G, <\/strong>and Xu, H<\/strong>. (2013) Regulation of membrane trafficking by signaling on endosomal and lysosomal membranes. Topical Review. Journal of Physiology. <\/em>(ePub July 22, 2013). PDF<\/a><\/a><\/p>\n\n\n\n

41. Wang, X. *, Zhang, X. *, Dong, X., Samie, M., Li, X., Cheng, X., Goschka, A., Shen., D.<\/strong>,  Zhou, Y., Harlow, J., Zhu, M.X., Clapham, D.E., Ren, D., and  Xu, H<\/strong>. (2012) TPC Proteins are Sodium-selective Ion Channels in the Endosomes and Lysosomes.  Cell <\/em>151, 373-383, Oct. 12, 2012). <\/a> Evaluated by F1000<\/strong><\/span>. PDF<\/a><\/p>\n\n\n\n

42. Zhang X., Li, X., <\/strong>and Xu, H<\/strong>. (2012) PIP2 Isoforms Determine Compartment-specific Ion Channel Activity . PNAS. <\/em>2012 (ePub June 25). PDF<\/a><\/a><\/p>\n\n\n\n

43 Yu, T, Chung C, Shen, D.,<\/strong> Xu, H<\/strong>., and Lieberman A.P (2012) Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann-Pick type C disease fibroblasts . Human Molecular Genetics. <\/em>2012 (ePub April 25). PDF<\/a><\/a><\/p>\n\n\n\n

44. Shen, D., Wang, X.<\/strong>, Li, X., Zhang, X., Yao, Z, Dibble, S., Dong, X.P<\/strong>, Yu, T, Lieberman A.P, and Xu, H<\/strong>. (2012) Lipid storage disorders block lysosomal trafficking by inhibiting TRP channel and calcium release. Nature Communications. <\/em>2012 Mar 13. 3 : 731 doi: 10.1038\/ncomms1735 <\/a> Evaluated by F1000<\/strong><\/span>. PDF<\/a><\/p>\n\n\n\n

45. Jin J, Wu LJ, Jun J, Cheng X,<\/strong> Xu H<\/strong>, Andrews NC, Clapham DE. (2011) The channel kinase, TRPM7, is required for early embryonic development. PNAS (plus) <\/em>ePub Dec 27, 2011. PDF<\/a><\/a><\/p>\n\n\n\n

46 Shen, D., Wang, X.<\/strong>, and Xu, H<\/strong>. (2011) Pairing Phosphoinositides with Calcium Ions in Endolysosomal Dynamics . BioEssays <\/em>2011 Jun;33(6):448-57. doi: 10.1002\/bies.201000152. Epub 2011 Apr 28. PDF<\/a><\/a><\/p>\n\n\n\n

47 Dong, XP.*, Shen, D.*, Wang, X.*, Dawson, T., Li, X., Zhang, Q., Cheng, X.<\/strong>, Zhang, Y., Weisman, L., Delling, M., and Xu, H<\/strong>. (2010) PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome . Nature Communications<\/em>, 1:38 doi: 10.1038\/ncomms1037 2010 . <\/a> Evaluated by F1000<\/strong>. PDF<\/a><\/p>\n\n\n\n

48. Samie, M.A<\/strong>, and Xu, H<\/strong>. (2010) Studying TRP Channels in Intracellualr Membranes. CRC press, Book chapter, TRP Channels–Methods in Signal Transduction Series. Chapter 19. PMID: 22593956 (Pubmed)<\/p>\n\n\n\n

49. Cheng, X.<\/strong>*, Jin, J.*, Hu, L., Shen, D., Dong, X., Samie, M.A, Knoff, J., Eisinger, B., Liu, M<\/strong>., Huang, S.M., Caterina, M.J., Dempsey, P., Michael, L.E., Dlugosz, A., Andrews, N., Clapham DE, and Xu H<\/strong>  (2010) TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation. Cell<\/em> 2010 10.1016\/j.cell.2010.03.013. PDF<\/a><\/a> Leading edge Preview<\/a> Cell 141, April 16 <\/a> Featured Publication<\/a> Science Signaling ec 122 April 20 <\/a> Evaluated by F1000<\/strong>.<\/span><\/p>\n\n\n\n

50. Cheng, X., Shen, D., Samie, M.A<\/strong>., and Xu, H<\/strong>. (2010) Mucolipins: Intracellular TRPML1-3 Channels (Invited review). FEBS Letters 2010 Jan. 12 (Epub ahead of print). PDF<\/a><\/p>\n\n\n\n

51. Mills, E, Dong, X., <\/strong>Wang, F., and Xu, H<\/strong>. (2010) Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders (Invited review). Future Medicinal Chemistry Jan. 2010, Vol. 2, No. 1, Pages 51-64. PDF<\/a><\/p>\n\n\n\n

52 Dong, X., Wang, X., <\/strong>and Xu, H.<\/strong> (2009) TRP Channels of Intracellular Membranes (Invited review). Journal of Neurochemistry2010 Jan. 28 (Epub ahead of print). PDF<\/a><\/p>\n\n\n\n

53. Dong, X.*, Wang,X.*, Shen,D.*,Chen, S., Liu, M., Wang, Y., Mills, E.,Cheng, X.<\/strong>, Delling, M., and Xu, H<\/strong>. (2009) Activating mutations of the TRPML1 channel revealed by proline scanning mutagenesis.J. Biol. Chem. 10.1074\/jbc.M109.037184. PDF<\/a><\/p>\n\n\n\n

54. Dong, X, Cheng, X., Mills, E.<\/strong>, Delling, M., Wang, F., Kurz, T. and Xu, H<\/strong>. (2008) The Type IV Mucolipidosis-Associated Protein TRPML1 is an Endo-lysosomal Iron Release Channel. Nature<\/em>, 2008 (advance online publication) doi:10.1038\/nature07311. PDF<\/a> Evaluated by F1000<\/strong>.<\/span><\/p>\n\n\n\n

55. Xu, H.<\/strong> *, Delling, M. *, Li, L*, Dong, X<\/strong>., and Clapham, DE (2007) Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint\u2013waddler mice.Proceedings (USA), 2007, Nov 13;104(46):18321-6. Epub 2007 Nov 7. PDF<\/a> Evaluated by F1000<\/strong>.<\/p>\n\n\n\n

(1998-2006)<\/p>\n\n\n\n

1.Xu, H.<\/strong>, Delling, M., Jun, JC, and Clapham, DE (2006) Oregano, Thyme, and Clove-derived Flavors and Skin Sensitizers Activate Specific TRP Channels. Nature Neuroscience<\/em> 2006 May; 9(5):628-635. Epub 2006 Apr 16<\/span>.PDF<\/a>

2. Xu, H.<\/strong>*, Blair, NT.*, and Clapham, DE. (2005) Camphor Activates and Strongly Desensitizes TRPV1 in a Vanilloid-independent Mechanism. The Journal of Neuroscience 2005; 25(39): 8924-37. PDF<\/a>. The work was highlighted in The Journal of Neuroscience, 2005 Sep 28; 25(39), Nature, 2005 Oct 13; 437: 930-931, and Nature Reviews Neuroscience, 2005, 6: 826.

3. Zhuang, ZY., Xu, H.<\/strong>, Clapham, DE., and Ji, RR.(2004) Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. The Journal of Neuroscience 2004; 24(38):8300-9. PDF<\/a>

4. Ito, M.*, Xu, H.<\/strong>*, Guffanti, A., Wei, Y., Zvi, L., Clapham, DE., and Krulwich, TA.(2004) The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis and pH homeostasis of an alkaliphilic Bacillus. Proceedings of the National Academy of Sciences (USA) 2004; 101(29): 10566-71. Epub 2004 Jul 08. PDF<\/a>

5. Moran, MM., Xu, H<\/strong>, and Clapham, DE. (2004) TRP ion channels in the nervous system. Current Opinion in Neurobiology 2004; 14(3): 362-9. PDF<\/a>

6. Xu, H.<\/strong>*, Jin, J.*, DeFelice, LJ., Andrews, NC., and Clapham, DE. (2004) A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biology 2004 Mar;2(3):E50. Epub 2004 Mar 16. Synopsis can be found at PLoS Biol. 2004 Mar;2(3):E70. Epub 2004 Mar 16. 

7. Koishi, R.*, Xu, H.<\/strong>*, Ren D., Navarro B., Spiller BW., Shi Q., and Clapham, DE. (2004) A superfamily of voltage-gated sodium channels in bacteria. Journal of Biological Chemistry. 279(10):9532-8. Epub 2003 Dec 09. PDF<\/a>

8. Xu, H.<\/strong>*, Ramsey, IS.*, Kotecha, SA.*, Moran, MM., Chong, JA., Curtis, R., DiStefano, PS., Silos-Santiago, I., Xie, Y., Lawson, D., Ge, P., Lilly, J., and Clapham, DE. (2002). TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature<\/em>, 418, 181-186, published online 23 June 2002; doi:10.1038\/nature00882. PDF <\/a>Comments about this work and other groups’ related articles see “Breakthrough of The Year” by Science, Vol 298, Issue 5602, 2297-2303, 20 December 2002.<\/span>

9. Ren, D.*, Navarro, B.*, Xu, H.<\/strong>*, Yue, L.*, Shi, Q., and Clapham, DE. (2001). A prokaryotic voltage-gated sodium channel. Science, Dec 14 2001: 2372-2375. Perspectives about this paper can be found in Science, 294: 2306-2308.PDF<\/a>

10. Wang, R., Rojas, A., Wu, J., Piao, H., Adams C. Y., Xu, H.<\/strong>, Shi, Y. and Jiang, C. (2005) Determinant role of membrane helices in gating of intracellular ligand-gated ion channels. Journal of Membrane Biology, 204, 1-10.

11. Wu, J., Xu, H.<\/strong>, Shen, W., and Jiang, C. (2004) Expression and coexpression CO2-sensitive Kir channels in brainstem neurons of rats. Journal of Membrane Biology, 197(3):179-91.

12. Cui, N. *, Wu, J. *, Xu, H.<\/strong> *, Wang, R., Rojas, A., Piao, H., Mao, J., Abdulkadir, L., Li, L., and Jiang, C. (2003) A threonine residues (Thr71) plays a critical role in the gating Kir6.2 channel by intracellular ATP and pH. Journal of Membrane Biology, 192, 111-122.

13. Wu, J., Xu, H.<\/strong>, Yang, Z., Wang, Y., Mao, J., and Jiang, C (2002). Protons activate homomeric Kir6.2 channels by selective suppression of the long and intermediate closures. Journal of Membrane Biology, 190, 105-116.

14. Wu, J., Cui, N., Piao, H., Wang, Y., Xu, H.<\/strong>, Mao, J., and Jiang, C. (2002). Allosteric modulation of the mouse Kir6.2 channel by intracellular H+ and ATP. Journal of Physiology (London). 543, 495-505.

15. Xu, H.<\/strong>, Wu, J., Cui, N., Abdulkadir, L., Wang, R., Mao, J., Giwa, LR., Chanchevalap, S., and Jiang, C. (2001). Distinct histidine residues control the acid-induced activation and inhibition of the cloned KATP channel. Journal of Biological Chemistry, 276, 38690-38696.

16. Jiang, C., Xu, H.<\/strong>, Cui, N., and Wu, J. (2001). An alternative approach to the identification of respiratory central chemoreceptors in the brainstem. Respiratory Physiology, 2001 Dec;129(1-2):141-157.

17. Piao, H., Cui, N., Xu, H.<\/strong>, Mao, J., Rojas, A., Wang, R., Abdulkadir, L., Li, L., Wu, J., and Jiang, C. (2001). Requirement of multiple protein domains and residues for gating KATP channels by intracellular pH. Journal of Biological Chemistry, 276, 36673-36680.

18. Cui, N., Giwa, LR., Xu, H.<\/strong>, Abdulkadir, L., and Jiang, C. (2001). Modulation of the heteromeric Kir4.1-Kir5.1 channels by pCO2 at physiological levels, Journal of Cellular Physiology, 189, 229-236.

19. Jiang, C., Qu, Z., and Xu, H.<\/strong> (2001). Gating of inward rectifier K+ channels by proton-mediated interactions of internal protein domains. Trend in Cardiovascular Medicine, 12, 5-13.

20. Xu, H.<\/strong>*, Cui, N.*, Yang, Z., Wu, J., Giwa, LR., Abdulkadir, L., Sharma, P., and Jiang, C. (2001). Direct activation of KATP channels by intracellular acidosis. Journal of Biological Chemistry, 276, 12898-12902. * Co-first author.

21. Xu, H.<\/strong>*, Yang, Z.*, Cui, N., Valesky, WW., and Jiang, C. (2000). A single residue responsible for the difference of Kir4.1 channel from Kir1.1 in pH-sensitivity, rectification and single channel conductance. Journal of Physiology (London), 528.2, pp. 267-277.

22. Xu, H.<\/strong>, Yang, Z., Cui, N., Giwa, LR., Abdulkadir, L., Patel, M., Sharma, P., Shan, G., Shen W., and Jiang C. (2000). Molecular determinants for the distinct pH sensitivity of Kir1.1 and Kir4.1. American Journal of Physiology (Cell) , 279: C1464-C1471.

23. Xu, H.<\/strong>, Cui, N., Yang, Z., Qu, Z., and Jiang, C. (2000). Modulation of Kir4.1 and Kir5.1 by hypercapnia and intracellular acidosis. Journal of Physiology (London), 524, 725-735.

24. Yang, Z., Xu, H.<\/strong>, Cui, N., Qu, Z., Chanchevalap, S., Shen, W., and Jiang, C. (2000). Biophysical and molecular mechanisms underlying the modulation of heteromeric Kir4.1-Kir5.1 channels by CO2 and pH. Journal of General Physiology 116: 33-46

25. Qu, Z., Yang, Z., Cui, N., Chanchevalap, S., Zhu, G., Liu, C., Xu, H.<\/strong>, Shen, W., Wu, J., Li, Y., and Jiang, C. (2000) Kir gating by proton-mediated interactions of N- and C-terminal domains. Journal of Biological Chemistry, 275, 31573-31580.

26. Zhu, G., Liu, C., Chanchevalap, S., Xu, H.<\/strong>, and Jiang, C. (2000) CO2 inhibits specific inward rectifier K+ channels by decreases in intra- and extracellular pH. Journal of Cellular Physiology, 183, 53-64.

27. Zhu, G., Zhang, Y., Xu, H.<\/strong> , and Jiang, C. (1998) Characterization of endogenous ionic currents of human embryonic kidney (HEK 293) cells, Journal of Neuroscience Methods. 81(1-2):73-83.<\/p>\n\n\n\n

* Co-first author.<\/p>\n","protected":false},"excerpt":{"rendered":"

(2007- present; after moving to Michigan; featured publications in red) 1. Du, W., Gu, M., Hu, M., Pinchi, P., Chen, W., Ryan., M, Nold, T., Bannaga, A., and Xu H (2021). Lysosomal release triggers mitochondria-mediated non-apoptotic cell death in metastatic melanoma. Cell Reports (in press). 2. Yue, L, and Xu H (2021).  TRP channels in health […]<\/p>\n","protected":false},"author":44,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-9","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.lsa.umich.edu\/haoxingx\/wp-json\/wp\/v2\/pages\/9","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.lsa.umich.edu\/haoxingx\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.lsa.umich.edu\/haoxingx\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.lsa.umich.edu\/haoxingx\/wp-json\/wp\/v2\/users\/44"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.lsa.umich.edu\/haoxingx\/wp-json\/wp\/v2\/comments?post=9"}],"version-history":[{"count":6,"href":"https:\/\/sites.lsa.umich.edu\/haoxingx\/wp-json\/wp\/v2\/pages\/9\/revisions"}],"predecessor-version":[{"id":306,"href":"https:\/\/sites.lsa.umich.edu\/haoxingx\/wp-json\/wp\/v2\/pages\/9\/revisions\/306"}],"wp:attachment":[{"href":"https:\/\/sites.lsa.umich.edu\/haoxingx\/wp-json\/wp\/v2\/media?parent=9"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}