RNA modifications

RNA can be covalently modified, in a manner similar to both proteins and DNA. These modifications can alter RNA structure, which ultimately influences function, metabolism, and/or localization. Among the roughly 100 modifications that have been identified on eukaryotic transcripts, N6-methyladenosine (m6A) is the most common. We are interested in understanding the structural changes that m6A induces, particularly as it relates to HIV-1 infection and viral gene expression.