{"id":29,"date":"2023-06-16T17:10:37","date_gmt":"2023-06-16T17:10:37","guid":{"rendered":"https:\/\/sites.lsa.umich.edu\/koziklab\/?page_id=29"},"modified":"2026-08-14T12:59:37","modified_gmt":"2026-08-14T12:59:37","slug":"publications-press","status":"publish","type":"page","link":"https:\/\/sites.lsa.umich.edu\/koziklab\/publications-press\/","title":{"rendered":"Publications & Press"},"content":{"rendered":"\n

Preprints<\/em> & Selected Publications<\/em><\/h3>\n\n\n\n

The redefined identity of\u00a0Prevotella<\/em>: new implications for oral, respiratory, and vaginal health<\/a><\/strong><\/p>\n\n\n\n

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For much of the 20th century, the field of bacteriology was dominated by a pathogen-centric view, which rightly focused scientific resources on identifying, characterizing, and eliminating the agents of infectious disease. However, this perspective has resulted in the relative neglect of abundant yet poorly characterized members of the human microbiota. Few genera embody this oversight more clearly than\u00a0Prevotella<\/em>. Despite being consistently found in high abundance across diverse human mucosal sites, including the oral cavity, airways, and vagina, the underlying physiological roles of the genus in both health and disease contexts remain largely unclear. This review traces the evolution of\u00a0Prevotella<\/em>\u00a0research and classification, arguing that the traditional \u201cfriend or foe\u201d dichotomy is insufficient. We contend that more mechanistic work at the species level is needed to elucidate the biology of\u00a0Prevotella<\/em>, especially after the most recent taxonomic reclassification. The knowledge derived from a mechanistic focus will offer profound benefits for understanding and treating complex polymicrobial diseases across multiple systems, including chronic respiratory infections, oral inflammatory conditions, and recurrent genitourinary dysbiosis.<\/p>\n<\/details>\n\n\n\n

The Aerotolerant Capacity of Lung Symbiont Preovtella melaninogenica<\/a><\/strong><\/p>\n\n\n\n

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This study provides a correction to the 100-year-old classification of\u00a0Prevotella melaninogenica<\/em>\u00a0as a strict obligate anaerobe. We demonstrate that this key member of the human microbiome is capable of robust growth under oxygen levels previously thought to be lethal. By identifying transcriptional responses associated with growth and survival, we predict how\u00a0Prevotella melaninogenica<\/em>\u00a0dominates the oxygenated niches of the respiratory tract. This work reveals the putative mechanisms driving the adaptive evolution of\u00a0Prevotella melaninogenica<\/em>\u00a0and its role in human airway ecology.<\/p>\n<\/details>\n\n\n\n

Development of a basal media for carbon utilization assay and analysis of the starch utilization locus in Prevotella melaninogenica<\/em><\/a><\/strong>
Complete genome sequence of Prevotella histicola<\/em> T05-04<\/a><\/strong><\/p>\n\n\n\n

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