Selected Publications

Po-Ju Chen, Isabel Martinez-Pena y Valenzuela, Mohamed Aittaleb, and Mohammed Akaaboune. AChRs are essential for the targeting of Rapsyn to the postsynaptic membrane of NMJs in living mice.The Journal of Neuroscience, 2016 (in press).

Mohamed Aittaleb, Po-Ju Chen, and Mohammed Akaaboune. Failure of Lysosome Clustering and positioning in the Juxtanuclear Region in Cells Deficient in Rapsyn.The Journal of Cell Science, 2015.

Isabel Martinez-Pena y Valenzuela, Mohamed Aittaleb, Po-Ju Chen, and Mohammed Akaaboune.The knockdown of αkap alters the postsynaptic apparatus of neuromuscular junctions in living mice. The Journal of Neuroscience, April 2015, 35(13):5118-5127. PDF.

Sreya Basu, Stefan Sladecek, Isabel Martinez de la Peña y ValenzuelaMohammed Akaaboune, Ihor Smal, Katrin Martin, Niels Galjart, and Hans Rudolf Brenner. CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles. Molecular Biology of the Cell.2015 Mar 1;26(5):938-51. PDF

Brenner HR, Akaaboune M. Recycling of acetylcholine receptors at ectopic postsynaptic clusters induced by exogenous agrin in living rats. Dev. Biol. 2014 Aug 2. pii: S0012-1606(14)00354-6. PDF

Chakib Mouslim*, Mohamed Aittaleb*, Richard I. Hume, and Mohammed Akaaboune. A role for the CaM Kinase II related anchoring protein (αkap) in maintaining the stability of nicotinic Acetylcholine Receptors. (2012). The Journal of Neuroscience. 2012 Apr 11;32(15):5177-85. PDF

Nadine Hardel#, Mohammed Akaaboune#, Isabel Martinez-Pena y Valenzuela, Sarah Wakefield, Raphael Thurnheer, and Hans Rudolf Brenneror. Neuregulin/ErbB stabilizes the postsynaptic apparatus of the neuromuscular junction. (2011). The Journal of Cell Biology. 2011 Dec 26;195(7):1171-84. Epub 2011 Dec 19. (# Mohammed Akaaboune is a Co-first and corresponding author).

Isabel Martinez-Pena y Valenzuela, Chakib Mouslim, Marcelo Pires-Oliveira, Marvin E. Adams, Stanley C. Froehner, and Mohammed Akaaboune. Nicotinic Acetylcholine Receptor Stability at the NMJ Deficient in α-syntrophin in vivo. (2011). The Journal of Neuroscience. Oct 26;31(43):15586-96. PDF

Isabel Martinez-Pena y Valenzuela, Chakib Mouslim and Mohammed Akaaboune. Calcium/Calmodulin Kinase II-dependent AChR Cycling at the Mammalian Neuromuscular Junction in Vivo. (2010). The Journal of Neuroscience. 30: 12455-12465. PDF

Emile G.Bruneau and Mohammed Akaaboune. Dynamics of the Rapsyn Scaffolding Protein at the Neuromuscular Junction of Live Mice. (2010). The Journal of Neuroscience. 2010 Jan 13;30(2):614-9. PDF

Emile G. Bruneau, Jose Esteban and Akaaboune M. Receptor-Associated Proteins and Synaptic Plasticity. (2009). FASEBJ. 23(3):679-88. PDF

Emile G. Bruneau, Daniel S. Brenner, John Y. Kuwada and Akaaboune M. Acetylcholine receptors are required for the insertion and maintenance of post-synaptic scaffolding proteins. (2008). Current Biology 2008. Jan 22;18(2):109-15. PDF

Isabel Martinez-Pena y Valenzuela and Mohammed Akaaboune. Acetylcholinesterase Mobility and Stability at the Neuromuscular Junction of Living Mice. (2007). Molecular Biology of the Cell. 2007 Aug;18(8):2904-11. PDF

Emile G. Bruneau and Mohammed Akaaboune. The dynamics of the rapsyn scaffolding protein at individual acetylcholine receptor clusters. (2007). J Biol Chem. Mar 30;282(13):9932-40. Epub 2007 Feb 5. PDF

Emile Bruneau and Mohammed Akaaboune. The Dynamics of Recycled Acetylcholine Receptors at the Neuromuscular Junction in vivo. (2006). Development. EPub 2006 Oct 18 [Epub ahead of print]. PDF

Emile Bruneau and Mohammed Akaaboune. Running to Stand Still, Ionotropic Receptor Dynamics at Central and Peripheral Syanpses. (2006). Molecular Neurobiology. (2):137-152. PDF

Krejci E, Martinez-Pena Y Valenzuela I, Ameziane R, and Akaaboune M. Acetylcholinesterase dynamics at the Neuromuscular Junction of Live Animals. (2006). J Biol Chem. Apr 14;281(15):10347-54. PDF

Bruneau EG, Macpherson PC, Goldman D, Hume RI, Akaaboune M. The effect of agrin and laminin on acetylcholine receptor dynamics in vitro. (2005). Dev Biol. Dec 1;288(1):248-58. Epub 2005 Oct 26. PDF

Bruneau E, Sutter D, Hume RI, and Mohammed Akaaboune. Identification of Nicotinic Acetylcholine Receptor Recycling and its Role in Maintaining Receptor Density at the Neuromuscular Junction in vivo. (2005). Journal of Neuroscience. 25:9949-59. PDF

Martinez-Pena y Valenzuela I, Hume RI, Krejci E, and Akaaboune M. In Vivo Regulation of Acetylcholinesterase Insertion at the Neuromuscular Junction. (2005). J Biol Chem. 280(36):31801-8. Epub 2005 Jul 5. PDF

Grady RM, Akaaboune M. Cohen AL, Maimone MM, Lichtman JW, Sanes JR. Tyrosine-phosphorylated and nonphosphorylated isoforms of {alpha}-dystrobrevin: roles in skeletal muscle and its neuromuscular and myotendinous junctions. (2003). J Cell Biol. 160: 741-752. PDF

Akaaboune M, Grady RM, Turney S, Sanes JR, and Lichtman JW. Neurotransmitter Receptor Dynamics Studied in vivo by Reversible Photo-Unbinding of Fluorescent Ligands. (2002). Neuron. 34: 865-876. PubMed

Akaaboune M., Allinquant B., Farza H., Roy K., Magoul R., Fiszman M., Festoff B.W., Hantai D. Developmental regulation of amyloid precursor protein at the neuromuscular junction in mouse skeletal muscle. (2000). Molecular & Cellular Neurosciences. 15: 355-67. PubMed

Akaaboune M., Culican S.M., Turney S.G., Lichtman J.W. Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo. (1999). Science (Research Article). 28: 503-7. PubMed

Akaaboune M., Hantai D., Smirnova I., Lachkar S., Kapsimali M., Verdiere-Sahuque M., Festoff B.W. Developmental regulation of the serpin, protease nexin I, localization during activity-dependent polyneuronal synapse elimination in mouse skeletal muscle. (1998). Journal of Comparative Neurology. 39: 572-9. PubMed