1 Padmanaban, S., Lambacher, N. J., Tesmer, V. M., Zhang, J., Shibuya, H. & Nandakumar, J. Caenorhabditis elegans telomere-binding proteins TEBP-1 and TEBP-2 adapt the Myb module to dimerize and bind telomeric DNA. Proc Natl Acad Sci U S A 121, e2316651121, (2024).
2 Tesmer, V. M., Brenner, K. A. & Nandakumar, J. Human POT1 protects the telomeric ds-ss DNA junction by capping the 5′ end of the chromosome. Science 381, 771-778, (2023). https://www.science.org/stoken/author-tokens/ST-1380/full
3 Moritz, L., Schon, S. B., Rabbani, M., Sheng, Y., Agrawal, R., Glass-Klaiber, J., Sultan, C., Camarillo, J. M., Clements, J., Baldwin, M. R., Diehl, A. G., Boyle, A. P., O’Brien, P. J., Ragunathan, K., Hu, Y. C., Kelleher, N. L., Nandakumar, J., Li, J. Z., Orwig, K. E., Redding, S. & Hammoud, S. S. Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1. Nat Struct Mol Biol, (2023).
4 Padmanaban, S., Tesmer, V. M. & Nandakumar, J. Interaction hub critical for telomerase recruitment and primer-template handling for catalysis. Life Sci Alliance 6, (2023).
5 Nagpal, N., Tai, A. K., Nandakumar, J. & Agarwal, S. Domain specific mutations in dyskerin disrupt 3′ end processing of scaRNA13. Nucleic Acids Res, (2022).
6 Agrawal, R., Gillies, J. P., Zang, J. L., Zhang, J., Garrott, S. R., Shibuya, H., Nandakumar, J. & DeSantis, M. E. The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor. eLife 11, (2022).
7 Wozniak, K. J., Burby, P. E., Nandakumar, J. & Simmons, L. A. Structure and kinase activity of bacterial cell cycle regulator CcrZ. PLoS Genet 18, e1010196, (2022).
8 Brenner, K. A. & Nandakumar, J. Consequences of telomere replication failure: the other end-replication problem. Trends in biochemical sciences 47, 506-517, (2022).
9 Graniel, J. V., Bisht, K., Friedman, A., White, J., Perkey, E., Vanderbeck, A., Moroz, A., Carrington, L. J., Brandstadter, J. D., Allen, F., Shami, A. N., Thomas, P., Crayton, A., Manzor, M., Mychalowych, A., Chase, J., Hammoud, S. S., Keegan, C. E., Maillard, I. & Nandakumar, J. Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline. Life Sci Alliance 5, (2022).
10 Zhang, K., Tarczykowska, A., Gupta, D. K., Pendlebury, D. F., Zuckerman, C., Nandakumar, J. & Shibuya, H. The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I. Cell reports 38, 110289, (2022).
11 Reilly, C. R., Myllymaki, M., Redd, R., Padmanaban, S., Karunakaran, D., Tesmer, V., Tsai, F. D., Gibson, C. J., Rana, H. Q., Zhong, L., Saber, W., Spellman, S. R., Hu, Z. H., Orr, E. H., Chen, M. M., De Vivo, I., DeAngelo, D. J., Cutler, C., Antin, J. H., Neuberg, D., Garber, J. E., Nandakumar, J., Agarwal, S. & Lindsley, R. C. The clinical and functional effects of TERT variants in myelodysplastic syndrome. Blood 138, 898-911, (2021).
12 Zhang, J., Nandakumar, J. & Shibuya, H. BRCA2 in mammalian meiosis. Trends Cell Biol, (2021).
13 Grill, S., Padmanaban, S., Friedman, A., Perkey, E., Allen, F., Tesmer, V. M., Chase, J., Khoriaty, R., Keegan, C. E., Maillard, I. & Nandakumar, J. TPP1 mutagenesis screens unravel shelterin interfaces and functions in hematopoiesis. JCI Insight, (2021).
14 Pendlebury, D. F., Zhang, J., Agrawal, R., Shibuya, H. & Nandakumar, J. Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites. Nat Struct Mol Biol 28, 671-680, (2021).
15 Gu, P., Jia, S., Takasugi, T., Tesmer, V. M., Nandakumar, J., Chen, Y. & Chang, S. Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres. Nature communications 12, 5514, (2021).
16 Grill, S. & Nandakumar, J. Molecular mechanisms of telomere biology disorders. J Biol Chem 296, 100064, (2020).
17 Zhang, J., Gurusaran, M., Fujiwara, Y., Zhang, K., Echbarthi, M., Vorontsov, E., Guo, R., Pendlebury, D. F., Alam, I., Livera, G., Emmanuelle, M., Wang, P. J., Nandakumar, J., Davies, O. R. & Shibuya, H. The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells. Nature communications 11, 2055, (2020).
18 Brenner, K. A. & Nandakumar, J. Small Molecules Restore Telomeres in Patient Stem Cells. Trends Pharmacol Sci 41, 506-508, (2020).
19 Smith, E. M., Pendlebury, D. F. & Nandakumar, J. Structural biology of telomeres and telomerase. Cell Mol Life Sci 77, 61-79, (2020).
20 Grill, S., Bisht, K., Tesmer, V. M., Shami, A. N., Hammoud, S. S. & Nandakumar, J. Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells. Cell reports 27, 3511-3521 e3517, (2019).
21 Tesmer, V. M., Smith, E. M., Danciu, O., Padmanaban, S. & Nandakumar, J. Combining conservation and species-specific differences to determine how human telomerase binds telomeres. Proc Natl Acad Sci U S A, (2019).
22 Gu, P., Jia, S., Takasugi, T., Smith, E., Nandakumar, J., Hendrickson, E. & Chang, S. CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length. Aging cell 17, e12783, (2018).
23 Grill, S., Tesmer, V. M. & Nandakumar, J. The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action. Cell reports 22, 1132-1140, (2018).
24 Pendlebury, D. F., Fujiwara, Y., Tesmer, V. M., Smith, E. M., Shibuya, H., Watanabe, Y. & Nandakumar, J. Dissecting the telomere-inner nuclear membrane interface formed in meiosis. Nat Struct Mol Biol 24, 1064-1072, (2017).
25 Gu, P., Wang, Y., Bisht, K. K., Wu, L., Kukova, L., Smith, E. M., Xiao, Y., Bailey, S. M., Lei, M., Nandakumar, J. & Chang, S. Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis. Oncogene 36, 1939-1951, (2017).
26 Bisht, K., Grill, S., Graniel, J. & Nandakumar, J. A lentivirus-free inducible CRISPR-Cas9 system for efficient targeting of human genes. Analytical biochemistry 530, 40-49, (2017).
27 Bisht, K., Smith, E. M., Tesmer, V. M. & Nandakumar, J. Structural and functional consequences of a disease mutation in the telomere protein TPP1. Proc Natl Acad Sci U S A 113, 13021-13026, (2016).
28 Jones, M., Bisht, K., Savage, S. A., Nandakumar, J., Keegan, C. E. & Maillard, I. The shelterin complex and hematopoiesis. The Journal of clinical investigation 126, 1621-1629, (2016).
29 Kocak, H., Ballew, B. J., Bisht, K., Eggebeen, R., Hicks, B. D., Suman, S., O’Neil, A., Giri, N., Laboratory, N. D. C. G. R., Group, N. D. C. S. W., Maillard, I., Alter, B. P., Keegan, C. E., Nandakumar, J. & Savage, S. A. Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1. Genes Dev 28, 2090-2102, (2014).
30 Nakashima, M., Nandakumar, J., Sullivan, K. D., Espinosa, J. M. & Cech, T. R. Inhibition of telomerase recruitment and cancer cell death. J Biol Chem 288, 33171-33180, (2013).
31 Nandakumar, J. & Cech, T. R. Finding the end: recruitment of telomerase to telomeres. Nat Rev Mol Cell Biol 14, 69-82, (2013).
32 Nandakumar, J., Bell, C. F., Weidenfeld, I., Zaug, A. J., Leinwand, L. A. & Cech, T. R. The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature 492, 285-289, (2012).
33 Nandakumar, J. & Cech, T. R. DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe. Nucleic Acids Res 40, 235-244, (2011).
34 Zaug, A. J., Podell, E. R., Nandakumar, J. & Cech, T. R. Functional interaction between telomere protein TPP1 and telomerase. Genes Dev 24, 613-622, (2010).
35 Nandakumar, J., Podell, E. R. & Cech, T. R. How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA. Proc Natl Acad Sci U S A 107, 651-656, (2010).
36 Nandakumar, J., Schwer, B., Schaffrath, R. & Shuman, S. RNA repair: an antidote to cytotoxic eukaryal RNA damage. Mol Cell 31, 278-286, (2008).
37 Nair, P. A., Nandakumar, J., Smith, P., Odell, M., Lima, C. D. & Shuman, S. Structural basis for nick recognition by a minimal pluripotent DNA ligase. Nat Struct Mol Biol 14, 770-778, (2007).
38 Wang, L. K., Nandakumar, J., Schwer, B. & Shuman, S. The C-terminal domain of T4 RNA ligase 1 confers specificity for tRNA repair. RNA 13, 1235-1244, (2007).
39 Nandakumar, J., Nair, P. A. & Shuman, S. Last stop on the road to repair: structure of E. coli DNA ligase bound to nicked DNA-adenylate. Mol Cell 26, 257-271, (2007).
40 Keppetipola, N., Nandakumar, J. & Shuman, S. Reprogramming the tRNA-splicing activity of a bacterial RNA repair enzyme. Nucleic Acids Res 35, 3624-3630, (2007).
41 Zhu, H., Nandakumar, J., Aniukwu, J., Wang, L. K., Glickman, M. S., Lima, C. D. & Shuman, S. Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D. Proc Natl Acad Sci U S A 103, 1711-1716, (2006).
42 Nandakumar, J., Shuman, S. & Lima, C. D. RNA ligase structures reveal the basis for RNA specificity and conformational changes that drive ligation forward. Cell 127, 71-84, (2006).
43 Nandakumar, J. & Shuman, S. Dual mechanisms whereby a broken RNA end assists the catalysis of its repair by T4 RNA ligase 2. J Biol Chem 280, 23484-23489, (2005).
44 Nandakumar, J. & Shuman, S. How an RNA ligase discriminates RNA versus DNA damage. Mol Cell 16, 211-221, (2004).
45 Nandakumar, J., Ho, C. K., Lima, C. D. & Shuman, S. RNA substrate specificity and structure-guided mutational analysis of bacteriophage T4 RNA ligase 2. J Biol Chem 279, 31337-31347, (2004).
46 Mehta, G. & Nandakumar, J. Novel tandem ring-opening/ring-closing metathesis reactions of functionalized cyclohexenoids derived from (-)-alpha-pinene. Tetrahedron Letters 43, 699-702, (2002).
47 Mehta, G. & Nandakumar, J. Restructuring alpha-pinene: novel entry into diverse polycarbocyclic frameworks. Tetrahedron Letters 42, 7667-7670, (2001).
