Publications

1          Graniel, J. V., Bisht, K., Friedman, A., White, J., Perkey, E., Vanderbeck, A., Moroz, A., Carrington, L. J., Brandstadter, J. D., Allen, F., Shami, A. N., Thomas, P., Crayton, A., Manzor, M., Mychalowych, A., Chase, J., Hammoud, S. S., Keegan, C. E., Maillard, I. & Nandakumar, J. Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline. Life Sci Alliance 5, (2022).

2          Grill, S., Padmanaban, S., Friedman, A., Perkey, E., Allen, F., Tesmer, V. M., Chase, J., Khoriaty, R., Keegan, C. E., Maillard, I. & Nandakumar, J. TPP1 mutagenesis screens unravel shelterin interfaces and functions in hematopoiesis. JCI Insight, (2021).

3          Pendlebury, D. F., Zhang, J., Agrawal, R., Shibuya, H. & Nandakumar, J. Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites. Nat Struct Mol Biol 28, 671-680, (2021).

4          Gu, P., Jia, S., Takasugi, T., Tesmer, V. M., Nandakumar, J., Chen, Y. & Chang, S. Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres. Nature communications 12, 5514, (2021).

5          Reilly, C. R., Myllymaki, M., Redd, R., Padmanaban, S., Karunakaran, D., Tesmer, V., Tsai, F. D., Gibson, C. J., Rana, H. Q., Zhong, L., Saber, W., Spellman, S. R., Hu, Z. H., Orr, E. H., Chen, M. M., De Vivo, I., DeAngelo, D. J., Cutler, C., Antin, J. H., Neuberg, D., Garber, J. E., Nandakumar, J., Agarwal, S. & Lindsley, R. C. The clinical and functional effects of TERT variants in myelodysplastic syndrome. Blood 138, 898-911, (2021).

6          Grill, S. & Nandakumar, J. Molecular mechanisms of telomere biology disorders. J Biol Chem, (2020).

7          Smith, E. M., Pendlebury, D. F. & Nandakumar, J. Structural biology of telomeres and telomerase. Cell Mol Life Sci 77, 61-79, (2020).

8          Brenner, K. A. & Nandakumar, J. Small Molecules Restore Telomeres in Patient Stem Cells. Trends Pharmacol Sci 41, 506-508, (2020).

9          Zhang, J., Gurusaran, M., Fujiwara, Y., Zhang, K., Echbarthi, M., Vorontsov, E., Guo, R., Pendlebury, D. F., Alam, I., Livera, G., Emmanuelle, M., Wang, P. J., Nandakumar, J., Davies, O. R. & Shibuya, H. The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells. Nature communications 11, 2055, (2020).

10        Grill, S., Bisht, K., Tesmer, V. M., Shami, A. N., Hammoud, S. S. & Nandakumar, J. Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells. Cell reports 27, 3511-3521 e3517, (2019).

11        Tesmer, V. M., Smith, E. M., Danciu, O., Padmanaban, S. & Nandakumar, J. Combining conservation and species-specific differences to determine how human telomerase binds telomeres. Proc Natl Acad Sci U S A, (2019).

12        Gu, P., Jia, S., Takasugi, T., Smith, E., Nandakumar, J., Hendrickson, E. & Chang, S. CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length. Aging cell 17, e12783, (2018).

13        Grill, S., Tesmer, V. M. & Nandakumar, J. The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action. Cell reports 22, 1132-1140, (2018).

14        Gu, P., Wang, Y., Bisht, K. K., Wu, L., Kukova, L., Smith, E. M., Xiao, Y., Bailey, S. M., Lei, M., Nandakumar, J. & Chang, S. Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis. Oncogene 36, 1939-1951, (2017).

15        Bisht, K., Grill, S., Graniel, J. & Nandakumar, J. A lentivirus-free inducible CRISPR-Cas9 system for efficient targeting of human genes. Analytical biochemistry 530, 40-49, (2017).

16        Pendlebury, D. F., Fujiwara, Y., Tesmer, V. M., Smith, E. M., Shibuya, H., Watanabe, Y. & Nandakumar, J. Dissecting the telomere-inner nuclear membrane interface formed in meiosis. Nat Struct Mol Biol 24, 1064-1072, (2017).

17        Bisht, K., Smith, E. M., Tesmer, V. M. & Nandakumar, J. Structural and functional consequences of a disease mutation in the telomere protein TPP1. Proc Natl Acad Sci U S A 113, 13021-13026, (2016).

18        Jones, M., Bisht, K., Savage, S. A., Nandakumar, J., Keegan, C. E. & Maillard, I. The shelterin complex and hematopoiesis. The Journal of clinical investigation 126, 1621-1629, (2016).

19        Kocak, H., Ballew, B. J., Bisht, K., Eggebeen, R., Hicks, B. D., Suman, S., O’Neil, A., Giri, N., Laboratory, N. D. C. G. R., Group, N. D. C. S. W., Maillard, I., Alter, B. P., Keegan, C. E., Nandakumar, J. & Savage, S. A. Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1. Genes Dev 28, 2090-2102, (2014).

20        Nandakumar, J. & Cech, T. R. Finding the end: recruitment of telomerase to telomeres. Nat Rev Mol Cell Biol 14, 69-82, (2013).

21        Nakashima, M., Nandakumar, J., Sullivan, K. D., Espinosa, J. M. & Cech, T. R. Inhibition of telomerase recruitment and cancer cell death. J Biol Chem 288, 33171-33180, (2013).

22        Nandakumar, J., Bell, C. F., Weidenfeld, I., Zaug, A. J., Leinwand, L. A. & Cech, T. R. The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature 492, 285-289, (2012).

23        Nandakumar, J. & Cech, T. R. DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe. Nucleic Acids Res 40, 235-244, (2011).

24        Zaug, A. J., Podell, E. R., Nandakumar, J. & Cech, T. R. Functional interaction between telomere protein TPP1 and telomerase. Genes Dev 24, 613-622, (2010).

25        Nandakumar, J., Podell, E. R. & Cech, T. R. How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA. Proc Natl Acad Sci U S A 107, 651-656, (2010).

26        Nandakumar, J., Schwer, B., Schaffrath, R. & Shuman, S. RNA repair: an antidote to cytotoxic eukaryal RNA damage. Mol Cell 31, 278-286, (2008).

27        Wang, L. K., Nandakumar, J., Schwer, B. & Shuman, S. The C-terminal domain of T4 RNA ligase 1 confers specificity for tRNA repair. RNA 13, 1235-1244, (2007).

28        Nair, P. A., Nandakumar, J., Smith, P., Odell, M., Lima, C. D. & Shuman, S. Structural basis for nick recognition by a minimal pluripotent DNA ligase. Nat Struct Mol Biol 14, 770-778, (2007).

29        Keppetipola, N., Nandakumar, J. & Shuman, S. Reprogramming the tRNA-splicing activity of a bacterial RNA repair enzyme. Nucleic Acids Res 35, 3624-3630, (2007).

30        Nandakumar, J., Nair, P. A. & Shuman, S. Last stop on the road to repair: structure of E. coli DNA ligase bound to nicked DNA-adenylate. Mol Cell 26, 257-271, (2007).

31        Nandakumar, J., Shuman, S. & Lima, C. D. RNA ligase structures reveal the basis for RNA specificity and conformational changes that drive ligation forward. Cell 127, 71-84, (2006).

32        Zhu, H., Nandakumar, J., Aniukwu, J., Wang, L. K., Glickman, M. S., Lima, C. D. & Shuman, S. Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D. Proc Natl Acad Sci U S A 103, 1711-1716, (2006).

33        Nandakumar, J. & Shuman, S. Dual mechanisms whereby a broken RNA end assists the catalysis of its repair by T4 RNA ligase 2. J Biol Chem 280, 23484-23489, (2005).

34        Nandakumar, J. & Shuman, S. How an RNA ligase discriminates RNA versus DNA damage. Mol Cell 16, 211-221, (2004).

35        Nandakumar, J., Ho, C. K., Lima, C. D. & Shuman, S. RNA substrate specificity and structure-guided mutational analysis of bacteriophage T4 RNA ligase 2. J Biol Chem 279, 31337-31347, (2004).

36        Mehta, G. & Nandakumar, J. Novel tandem ring-opening/ring-closing metathesis reactions of functionalized cyclohexenoids derived from (-)-alpha-pinene. Tetrahedron Letters 43, 699-702, (2002).

37        Mehta, G. & Nandakumar, J. Restructuring alpha-pinene: novel entry into diverse polycarbocyclic frameworks. Tetrahedron Letters 42, 7667-7670, (2001).

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