researchimage03In addition to primary research articles, the Raymond Laboratory has also published:



Research Articles
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Research Articles

Nagashima M,  D’Cruz TD,  Danku AE, Hesse D, Sifuentes C, Raymond PA and Hitchcock PF (2020). Midkine-a is required for cell cycle progression of Müller glia during neuronal regeneration in the vertebrate retina.

Fu J, Nagashima M, Guo C, Raymond PA, Wei X. (2018). Novel animal models of Crumbs-dependent progressive retinal degeneration that targets specific cone subtypes. Invest Ophthalmol Vis Sci. 59(1):505-518.

Nagashima, M., Hadidjojo, J., Barthel, L. K., Lubensky, D. K., & Raymond, P. A. (2017). Anisotropic Müller glial scaffolding supports a multiplex lattice mosaic of photoreceptors in zebrafish retina. Neural Development12, 20.

Sifuentes, C.J., Kim, J.W., Swaroop, A., Raymond, P.A. (2016). Rapid, dynamic activation of Müller glial stem cell responses in zebrafish. Invest. Ophthal. Vis. Sci. 57:5148-5160.

Yoshimatsu T., Williams P.R., D’Orazi F.D., Suzuki S.C., Fadool J.M., Allison W.T., Raymond P.A., Wong R.O. (2014). Transmission from the dominant input shapes the stereotypic ratio of photoreceptor inputs onto horizontal cells. Nat. Commun. 15:3699.

Raymond, P.A., Colvin, S.M., Jabeen, Z., Nagashima, M., Barthel, L.K., Hadidjojo, J., Popova, L., Pejaver, V.R., and Lubensky, D.K. (2014). Patterning the cone mosaic array in zebrafish requires specification of ultraviolet-sensitive cones. PLOS ONE 9:e85325.

Nagashima, M., Barthel, L.K. and Raymond, P.A. (2013). A self-renewing division of zebrafish Müller glial cells generates neuronal progenitors that require N-cadherin to regenerate retinal neurons. Development 140:4510-21.

Lenkowski JQin ZSifuentes CJThummel RSoto CMMoens CBRaymond PA. (2013). Retinal regeneration in adult zebrafish requires regulation of TGFβ signaling. Glia. Oct;61(10):1687-97.

Meyers, J.R., Hu, D., Moses, A., Kaboli, K., Papandrea, A., and Raymond, P.A. (2012). β-catenin/Wnt signaling controls progenitor fate in the developing and regenerating zebrafish retina. Neural Dev. 7:30-47. (Cover photo)

Salbreux, G., Barthel, L.K., Raymond, P.A., and Lubensky, D.K. (2012). Coupling mechanical deformations and planar cell polarity to create regular patterns in the zebrafish retina. PLoS Comp. Biol. 8: e1002618.

Calinescu, A.-A., Raymond, P.A. and Hitchcock, P.F. (2009). Midkine expression is regulated by the circadian clock in the retina of the zebrafish. Visual Neurosci. 26:495-501.

Qin Z, Barthel LK, Raymond PA. (2009). Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish Proc Natl Acad Sci U S A. 106(23):9310-5.

Buchner DA, Su F, Yamaoka JS, Kamei M, Shavit JA, Barthel LK, McGee B, Amigo JD, Kim S, Hanosh AW, Jagadeeswaran P, Goldman D, Lawson ND, Raymond PA, Weinstein BM, Ginsburg D, Lyons SE. (2007). pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Proc Natl Acad Sci U S A 104(35):13996-4001.

Bernardos RL, Barthel LK, Meyers JR, Raymond PA. (2007). Late-stage neuronal progenitors in the retina are radial Muller glia that function as retinal stem cells. J Neurosci. 27:7028-2040.

Catalano AE, Raymond PA, Goldman D, Wei X. (2007). Zebrafish dou yan mutation causes patterning defects and extensive cell death in the retina. Dev Dyn. 236:1295-1306.

Bernardos RL, Raymond PA. (2006). GFAP transgenic zebrafish. Gene Expr Patterns. (8):1007-13.

Raymond PA, Barthel LK, Bernardos RL, Perkowski JJ. (2006). Molecular characterization of retinal stem cells and their niches in adult zebrafish. BMC Dev Biol. 6:36 (17 pages).

Bernardos, RL, Lentz SI, Wolfe MS, Raymond PA (2005). Notch-Delta signaling is required for spatial patterning and Müller glia differentiation in the zebrafish retina. Dev. Biol. 278(2): 381-95.

Wehman AM, Staub W, Meyers JR, Raymond, PA, Baier H (2005). Genetic dissection of the zebrafish retinal stem-cell compartment. Dev. Biol. 281(1): 53-65.

Shen YC, Raymond PA (2004). Zebrafish cone-rod (crx) homeobox gene promotes retinogenesis. Dev. Biol. 269(1): 237-51.

Novince. Z.M., E. Axoldi, J.A., Marrs, P.A. Raymond and Q. Liu (2003). Cadherin expression in the inner ear of developing zebrafish, Danio rerio. Mech. Dev. 3:337-339.

Gamse J.T., Shen Y.C., Thisse C., Thisse B., Raymond P.A., Halpern M.E., Liang J.O. (2002). Otx5 regulates genes that show circadian expression in the zebrafish pineal complex. Nat Genet 30:117-21.

Liu, Q., R.L. Londraville, E. Azodi, S.G. Babb, C. Chiappini, J.A. Marrs and P.A. Raymond (2002). Up-regulation of cadherin-2 and cadherin-4 in regenerating visual structures of adult zebrafish. Exp. Neurol. 177:396-406.

Liu, Y.*, Shen, Y.C.*, Rest, J.S., Raymond, P.A. and D.J.Zack (2001). Isolation and characterization of a zebrafish homolog of the cone rod homeobox (crx) gene. *These authors contributed equally to the study. Invest. Ophthal. Vis. Sci. 42:481-487.

Chuang, J.C. and P.A. Raymond (2001). Zebrafish genes rx1 and rx2 help define the forebrain region that gives rise to retina. Devel. Biol. 231:13-30.

Babb, S.G., J.Barnett, A.L., Doedens, N. Cobb, Q. Lin, B.C. Sorkin, P.C. Yelick, P.A. Raymond, W.J. Gallin, and J.A. Marrs (2001). Zebrafish E-cadherin: phylogenic analysis, expression during early embryogenesis and regulation during midbrain-hindbrain boundary formation. Devel. Dynamics 221:231-237.

Wu, D.M., T. Schneiderman, J. Burgett, P. Gokhale, L. Barthel, P.A. Raymond (2001). Cones regenerate from retinal stem cells sequestered in the inner nuclear layer of adult goldfish retina Invest. Ophthal. Vis. Sci. 42:2115-2124.

Liu, Q., Marrs, J.A., Chuang, J.C. and P.A. Raymond (2001). Cadherin-4 expression in the zebrafish central nervous system and regulation by ventral midline signaling. Brain Res. Devel. Brain Res. 131:17-29.

Liu, Q., S. G. Babb, Z.M. Novince, A.L. Doedens, J.A. Marrs and P.A. Raymond (2001). Differential expression of cadherin-2 and cadherin-4 in the developing zebrafish visual system. Visual Neurosci. 18:923-933.

Gamm, D.M., Barthel, L.K., Raymond, P.A. and M.D. Uhler (2000). Localization of cGMP-dependent protein kinase isoforms in mouse eye. Invest. Ophthal. Vis. Sci. 41:2766-2773.

Stenkamp, D.L., R.A. Frey, S.N. Pradhudesai and P.A. Raymond (2000). Function for hedgehog genes in zebrafish retinal development. Devel. Biol. 220:238-252.

Liu, Q., K. Sanborn, N. Cobb, P.A. Raymond and J.A. Marrs (1999). R-cadherin expression in the developing and adult nervous system. J. Comp. Neurol. 410:303-319.

Liu, Q., J.A. Marrs and P.A. Raymond (1999). Spatial correspondence between R-cadherin expression domains and retinal ganglion cell axons in developing zebrafish. J.Comp. Neurol. 410:290-302.

Chuang, J.C., P.H. Mathers and P.A. Raymond (1999). Expression of three Rx genes in embryonic and adult zebrafish. Mech. Devel. 84:195-198.

Passini M.A., Kurtzman A.L., Canger A.K., Asch W.S., Wray G.A., P.A. Raymond, and N. Schechter (1998). Cloning of zebrafish vsx1: expression of a paired-like homeobox gene during CNS development. Dev Genet 23(2):128-41.

Passini, MA. PA Raymond and N Schechter (1998). Vsx-2, a gene encoding a paired-type homeodomain, is expressed in the retina, hindbrain, and spinal cord during goldfish embryogenesis. Dev Brain Res 109(2):129-35.

Stenkamp DL, LL Cunningham, PA Raymond, and F Gonzalez-Fernandez (1998). Novel expression pattern of interphotoreceptor retinoid-binding protein (IRBP) in the adult and developing zebrafish retina and RPE. Mol Vis Dec 2, 4:26.

Rajendran, R.R., E.E. Van Niel, D.L. Stenkamp, L.L. Cunningham, P.A. Raymond and F. Gonzalez-Fernandez (1997). Zebrafish interphotoreceptor retinoid-binding protein: differential circadian expression among cone subtypes. J Exp Biol 199:2775-87.

Stenkamp, D.L., L.K. Barthel and P.A. Raymond (1997). patiotemporal coordination of rod and cone photoreceptor differentiation in goldfish retina. J Comp Neurol 382:272-84.

Sullivan, S.A., L.K. Barthel, B.L. Largent and P.A. Raymond (1997). A goldfish Notch-3 homologue is expressed in neurogenic regions of embryonic, adult and regenerating brain and retina. Dev Genet 20:208-23.

Passini, M.A. Levine, E.M., Canger A.K., P.A. Raymond and N. Schechter (1997). Vsx-1 and Vsx-2: differential expression of two paired-like homeobox genes during zebrafish and goldfish retinogenesis. J Comp Neurol 388(3):495-505.

Hisatomi, O., S. Takumori, L.K. Barthel, D.L. Stenkamp, P.A. Raymond, and F. Tokunaga (1996). Molecular cloning and characterization of the putative ultraviolet-sensitive visual pigment of goldfish. Vision Res 36:933-9.

Stenkamp, D.L., O. Hisatomi, L.K. Barthel, F. Tokunaga and P.A. Raymond (1996). Temporal expression of rod and cone opsins in embryonic goldfish retina predicts the spatial organization of the cone mosaic. Invest Ophthal Vis Sci 37:363-76.

Raymond, P.A., L.K. Barthel and D.L. Stenkamp (1996). The zebrafish ultraviolet cone opsin reported previously is expressed in rods. Invest Ophthal Vis Sci 37:948-50.

Raymond, P.A. , L.K. Barthel and G.A. Curran (1995). Developmental patterning of rod and cone photoreceptors in embryonic zebrafish. J Comp Neurol 359:537-50.

Knight, J.K., and P.A. Raymond (1995). Retinal pigmented epithelium does not transdifferentiate in adult goldfish. J Neurobiol 27:447-56.

Braisted, J.E., T.F. Essman and P.A. Raymond (1994). Selective regeneration of photoreceptors in goldfish retina. Development 120:2409-19.

Wilmot, G.R., P.A. Raymond and B.W. Agranoff (1993). The expression of the protein p68/70 within the goldfish visual system suggests a role in both regeneration and neurogenesis. J Neurosci 13:387-401.

Raymond, P.A., L.K. Barthel, M.E. Rounsifer, S.A. Sullivan and J.K. Knight (1993). Expression of rod and cone visual pigments in goldfish and zebrafish: A rhodopsin-like gene is expressed in cones. Neuron 10:1161-74.

Barthel, L.K. and P.A. Raymond (1993). Subcellular localization of alpha-tubulin and opsin mRNA in the goldfish retina using digoxigenin-labeled cRNA probes detected by alkaline phosphatase and HRP histochemistry. J Neurosci Meth 50:145-52.

Braisted, J.E. and P.A. Raymond (1993). Continued search for the cellular signals that regulate regeneration of dopamingeric neurons in goldfish retina. Dev Brain Res 76:221-32.

Braisted, J.E. and P.A. Raymond (1992). Regeneration of dopaminergic neurons in goldfish retina. Development 114:913-9.

Wagner, E.C. and P.A. Raymond (1991). Muller glial cells of the goldfish retina are phagocytic in vitro but not in vivo. Exp Eye Res 53:583-9.

Raymond, P.A., L.K. Barthel and M.E. Rounsifer (1991). Immunolocalization of basic fibroblast growth factor and its receptor in adult goldfish retina. Exp Neurol 115:73-8.

Barthel, L.K. and P.A. Raymond (1990). Improved method for obtaining 3-micron cryosections for immunocytochemistry. J Histochem Cytochem 38:1383-8.

Raymond, P.A. (1990). Horizontal cell axon terminals in growing goldfish. Exp Eye Res 51:675-83.

Knight, J.K. and P.A. Raymond (1990). Time course of opsin expression in developing rod photoreceptors. Development 110:1115-20.

Stuermer, C.A.O., and P.A. Raymond (1989). The developing retinotectal projection in larval goldfish. J Comp Neurol 281:630-40.

Mountz, J.M., P.A. Raymond, P.E. McKeever, J.G. Modell, T.W. Hood, L.K. Barthel, and K.A. Stafford-Schuck (1989). Specific localization of Thalium-201 in human high-grade astrocytoma by microautoradiography. Cancer Res 49:4053-6.

Raymond, P.A., C.J. Bassi, and M.K. Powers (1988). Lighting conditions and retinal development in goldfish: Photoreceptor number and structure. Invest Ophthal Vis Sci 29:27-36.

Powers, M.K., C.J. Bassi, L.A. Rone and P.A. Raymond (1988). Lighting conditions and retinal development in goldfish: absolute visual sensitivity. Invest Ophthal Vis Sci 29:37-43.

Powers, M.K., C.J. Bassi, L.A. Rone and P.A. Raymond (1988). Visual detection by the rod system in goldfish of different sizes. Vision Res 28:211-21.

Raymond, P.A., M.J. Reifler, and P.K. Rivlin (1988). Regeneration of goldfish retina: rod precursors are a likely source of regenerated cells. J Neurobiol 19:431-63.

Bernhardt, R., S.S. Easter and P.A. Raymond (1988). Axons added to the regenerated visual pathway of goldfish establish a normal fiber topography along the age-axis. J Comp Neurol 277:420-9.

Raymond, P.A., P.F. Hitchcock, and M.F. Palopoli (1988). Neuronal cell proliferation and ocular enlargement in Black Moor goldfish. J Comp Neurol 276:231-8.

Raymond, P.A. and P.K. Rivlin (1987). Germinal cells in the goldfish retina that produce rod photoreceptors. Dev Biol 122:120-38.

Rivlin, P.K. and P.A. Raymond (1987). Use of osmium tetroxide-potassium ferricyanide for reconstructing cells from serial ultrathin sections. J Neurosci Meth 20:23-33.

Raymond, P.A. (1986). Movement of retinal terminals in goldfish optic tectum predicted by analysis of neuronal proliferation. J Neurosci 6:2479-88.

Raymond, P.A. (1985). Cytodifferentiation of photoreceptors in larval goldfish: delayed maturation of rods. J Comp Neurol 236:90-105.

Raymond, P.A. and S.S. Easter (1983). Postembryonic growth of the optic tectum in goldfish. I. Location of germinal cells and numbers of neurons produced. J Neurosci 3:1077-91.

Raymond, P.A., S.S. Easter, M.K. Powers and J.A. Burnham (1983). Postembryonic growth of the optic tectum in goldfish. II.Regulation of cell proliferation by retinal fiber input. J. Neurosci 3:1092-9.

Johns, P. Raymond (1982). The formation of photoreceptors in larval and adult goldfish. J Neurosci 2:178-98.

Johns, P. Raymond and R.D. Fernald (1981). Genesis of rods in teleost fish retina. Nature 293:141-2.

Johns, P. Raymond, A.C. Rusoff and M.W. Dubin (1979). Postnatal neurogenesis in the kitten retina. J Comp Neurol 187:545-55.

Johns, P. Raymond, A.M. Heacock and B.W. Agranoff (1978). Neurites in explant cultures of adult goldfish retina derived from ganglion cells. Brain Res 142:531-7.

Johns, P. Raymond, M.G. Yoon and B.W. Agranoff (1978). Directed outgrowth of optic fibers regenerating in vitro. Nature 271:360-2.

Easter, S.S., P. Raymond Johns and L. Baumann (1977). Growth of the adult goldfish eye. I. Optics. Vision Res 17:469-77.

Johns, P. Raymond, S.S. Easter (1977). Growth of the adult goldfish eye. II. Increase in retinal cell number. J Comp Neurol 176:331-41.

Johns, P. Raymond (1977). Growth of the adult goldfish eye. II. Increase in retinal cell number. J Comp Neurol 176:331-41.

Johns, P. Raymond (1977). Growth of the adult goldfish eye. III. Source of the new retinal cells. J Comp Neurol 176:343-58.

Easter, S.S. and P. Raymond Johns (1974). Horizontal compensatory eye movements in goldfish (Carassius auratus). II. A comparison of normal and deafferented animals. J Comp Physiol 92:37-57.

Easter, S.S., P. Raymond Johns and D. Heckenlively (1974). Horizontal compensatory eye movements in goldfish (Carassius auratus). I. The normal animal. J Comp Physiol. 92:23-35.

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Scientific Reviews

Raymond, P.A. (2016). Regeneration: New Neurons Wire Up. Current Biology 26:R794-6.

Lenkowski, J. and P.A. Raymond. (2014). Müller glial-dependent generation and regeneration of retinal neurons in teleost fish. Prog. Retinal and Eye Res. 40:94-123.

Qin, Z. and P.A. Raymond. (2012). Microarray-based gene profiling analysis of Müller glia-derived retinal stem cells in light-damaged retinas from adult zebrafish. Methods Mol. Biol. 884:255-261.

Adler R, Raymond PA. (2008). Have we achieved a unified model of photoreceptor cell fate specification in vertebrates? Brain Res. 1192:134-50.
Raymond P.A., Barthel, L.K. (2004). A moving wave patterns the cone photoreceptor mosaic array in the zebrafish retina. Int. J. Devel. Biol. 48(8-9):935-45.

Chuang, J.C. and P.A. Raymond (2002). Embryonic origin of the vertebrate retina: new perspectives from studies on zebrafish. BioEssays 24:1-11.

Hitchcock, P.F. and P.A. Raymond (1992). Retinal regeneration. Trends Neurosci 15:103-8.

Raymond, P.A. (1985). The unique origin of rod photoreceptors in the teleost retina. Trends Neurosci 8:12-7.

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Book Reviews

Raymond, P.A. (2006). Review of Developmental Neurobiology, 2nd Edition, D. Sanes, T. Reh, W.A. Harris, Academic Press. Quart. Rev. Biol. 81:306.

Raymond, P.A. (2002). Review of Developmental Neurobiology, D. Sanes, T. Reh, W.A. Harris, Academic Press. Quart. Rev. Biol. 77:99.

Raymond, P.A. (2000). Review of Development and Organization of the Retina: From Molecules to Function, NATO-ASI Series A: Life Sciences, Volume 299, L. M. Chalupa and B.L. Finlay, editors, Plenum Press. Quart. Rev. Biol. 75:82.

Raymond, P.A. (1983). Information flow among developing cells. Cell 32:1013-4.

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Raymond, P.A., ed. (2000). Origin of Neuronal Diversity in the Retina, Cell Mol Life Sciences 57(2):183-234.

Raymond, P.A., S.S. Easter and G.M. Innocenti, eds. (1990). Systems Approaches to Developmental Neurobiology, NATO ASI Series A, vol. 192, Plenum Press, NY.

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Chapters in Books or Symposium Volumes

The Lasker/IRRF Initiative for Innovation in Vision Science. 2014. Chapter 4 – Restoring Vision to the Blind: Stem Cells and Transplantation. Trans. Vis. Sci. Tech.: December 2014, Vol. 3, No. 7.

The Lasker/IRRF Initiative for Innovation in Vision Science. 2014. Chapter 5 – Restoring Vision to the Blind: Endogenous Regeneration. Trans. Vis. Sci. Tech.: December 2014, Vol. 3, No. 7.

Raymond, P.A. (2007). Defining a retinal stem cell niche. In Strategies for Retinal Tissue Repair and Regeneration in Vertebrates: From Fish to Human, C. Chiba, ed., Research Signpost, Kerala, Indua.

Raymond, P.A. (2004). Restoration of vision. In Handbook of Stem Cells: Volume 1: Adult & Fetal Stem Cells, R. Lanza, Coordinating ed., Elsevier Science, San Diego, CA pp. 703-709.

Raymond, P.A. and P.F. Hitchcock (2000). How the neural retina regenerates. In Vertebrate Eye Development, M.E. Fini, ed., Results and Problems in Cell Differentiation, Vol. 31, Springer-Verlag, NY pp. 197-218.

Barthel, L.K. and P.A. Raymond (2000). In situ hybridization studies of retinal neurons. In Vertebrate Phototransduction and the Visual Cycle, K. Palczewski, ed., Methods in Enzymology, vol. 316, Part B, J.N. Abelson and M.I. Simon, eds., Academic Press, Orlando, FL pp. 579-590.

Raymond, P.A., and P.F. Hitchcock (1996). Retinal regeneration: Common principles but a diversity of mechanisms. In Neuronal Regeneration, Reorganization and Repair, Advances in Neurology, F. J. Seil, ed., Raven Press, NY pp. 171-84.

Raymond, P.A. (1994). Development and morphological organization of photoreceptors. In Neurobiology of the Vertebrate Outer Retina, S. Archer, M.B.A. Djamgoz and S. Vallerga, eds., Chapman & Hall, London pp. 1-23.

Raymond, P.A. (1991). Cell determination and positional cues in the teleost retina: Development of photoreceptors and horizontal cells. In Development of the Visual System, Ret. Res. Fnd. Symp. Vol. 3, C. Shatz and D.M.K. Lam, eds., MIT Press, MA pp. 59-78.

Raymond, P.A. (1991). Retinal regeneration in teleost fish. In Regeneration of Vertebrate Sensory Cells, Ciba Fnd. Symp. Vol. 160, E. Rubel, ed., Wiley, London pp. 171-86.

Powers, M.K. and P.A. Raymond (1990). Development of the visual system. In The Visual System of Fish, R.H. Douglas and M.B.A. Djamgoz, eds., Chapman and Hall, London pp. 419-42.

Braisted, J.E. and P.A. Raymond (1990). Lineage versus environment as a determinant of neuronal phenotype. In Systems Approaches to Developmental Neurobiology, P.A. Raymond, S.S. Easter and G.M. Innocenti, eds., Plenum Press, NY pp. 29-40.

Raymond, P.A. (1988). M. Fulton, A., Abramov, I., Allen, J., Gwiazsa, J., Hainline, L., Masland, R.H., O’Neill, J., Raymond, P., and Varner, D. (1986). Visual development. In M. Waxler and V. Hitchins (eds.), Light Toxicity. Report of the FDA-NCRDH workshop on long-term visual health risks of optical radiation. Boca Raton, Florida: CRC Press pp. 137-46.

Borer, K.T., Raymond, P. and L. Dokas (1983). Neuroendocrine effects of exercise. In Frontiers of Exercise Biology, Borer, K.T., Eddington, D.W. and T.P. White, eds., Human Kinetics Press, Champagne, Ill. pp. 263-83.

Johns, P. Raymond (1981). Growth of fish retinas. Amer Zool 21:441-53.

Johns, P.R. (1979). Growth and neurogenesis in adult goldfish retina. In Developmental Neurobiology of Vision,R.D. Freeman, ed., Plenum Press, New York pp. 345-57.

Johns, P. Raymond and S.S. Easte (1975). Retinal growth in adult goldfish. In Vision in Fishes: New Approaches in Research,M.A. Ali, ed., Plenum Press, New York pp. 451-7.

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