New Publication from the Ruotolo lab!

A multi-disciplinary approach was employed to study Spy, a small ATP-independent chaperone that simultaneously acts as a protein foldase and holdase molecule. This work demonstrates the Spy chaperones mechanism is substrate specific and dependent on relative affinity for a proteins intermediate folding states which highlights the central and dynamic role that substrates have throughout the…

New Publication from the Ruotolo lab!

Through an extensive characterization of travelling wave ion mobility (TWIM) calibrations protocols using over 2500 experimental TWIM datasets, and ranging across several molecular classes spanning over 3.5 orders of magnitude in molecular mass, a robust calibration method has been developed that offers high-precision ccs measurements for existing and future TWIM instrumentation. Check our the publication…