The induction of c-fos mRNA in rats given saline or amphetamine in their home cage or after placement into a novel environment. The animals have a unilateral 6-OHDA lesion of the nigrostriatal system and the intact hemisphere is on the left. Note the large effect of environment on amphetamine-evoked c-fos mRNA expression.
from Badiani, A., Oates, M., Day, H.E.W., Watson, S.E., Akil, H. and Robinson, T.E. Amphetamine-induced behavior, dopamine release and c-fos mRNA expression: modulation by environmental novelty. Journal of Neuroscience, 1998, 18, 10579-10593.