Former Lab Members

Sania Mancer : Graduated

Sania Mancer

Graduated

Sania received acceptance to graduate programs at UW-Madison, Northwestern, CU-Boulder and University of Michigan.  She is doing her graduate work in the Biological Chemistry PIBS program at the University of Michigan Medical school.

Matthew Crotteau : Undergraduate Researcher

Matthew Crotteau

Undergraduate Researcher

Matt graduated in December 2023 and worked in the Bardwell lab until July 2024 as a research assistant. He will be attending graduate school at Johns Hopkins studying Cell, Molecular, Developmental Biology, and Biophysics

Xiaomeng (Steven) Liu : Undergraduate Researcher

Xiaomeng (Steven) Liu

Undergraduate Researcher

graduated May 2024, was accepted into graduate programs at Scripts and Johns Hopkins.  He will be attending graduate school at Johns Hopkins studying Chemistry.

Mark Dulchavsky : Graduate Student

Mark Dulchavsky

Graduate Student

former MD-PhD student and recipient of the MSTP Dean’s Award for Research Excellence.  Interviewed for Residency programs at Harvard, NIH, and University of Michigan.  Will be doing his Residency at the University of Michigan in Pediatrics.

 

Nathan Clark : Undergraduate Researcher

Nathan Clark

Undergraduate Researcher

graduated May 2024 and plans to pursue a job in industry. He is a co-author on published manuscripts.

Harry Yang : Undergraduate Researcher

Harry Yang

Undergraduate Researcher

Graduated May 2024, was accepted into MD-PhD programs at Penn State, Ohio State, Tufts, University of Minnesota, and University of Michigan.  He will be attending University of Michigan – MD-PhD program in the fall of 2024. He is a co-author on published manuscripts.

Scott Horowitz : Postdoctoral Fellow

Scott Horowitz

Postdoctoral Fellow

horowsah@umich.edu

Scott Horowitz first became interested in molecular structure and dynamics as an undergraduate student looking for a way to understand the biological world from the most basic building blocks of physics and chemistry. In his doctoral work, Scott investigated the role of unconventional hydrogen bonds in S-adenosylmethionine-dependent methylation, providing evidence not only for their existence but also their specific biological roles and importance in enzyme function.

As a member of the Bardwell laboratory, Scott is continuing to take an atomistic approach to studying biology, trying to understand the details of chaperone function using various structural biology techniques. In his spare time, Scott enjoys singing, listening, reading, and talking about music, and playing golf.

Listen to Scott's interview on NPR's Marketplace Tech.

[expand title="Publications"]Google Scholar
[/expand]

Ricky Stull : Postdoctoral Fellow

Ricky Stull

Postdoctoral Fellow

fstull@umich.edu

Ricky is from Florida. He received his PhD at the University of Michigan, where he studied the reaction mechanisms of flavin-dependent enzymes. In the Bardwell lab, he studies the mechanism of chaperone activation and function. Outside of lab, he enjoys cycling, baseball, and homebrewing.

[expand title="Publications"] R Teufel, F Stull, MJ Meehan, Q Michaudel, PC Dorrestein, B Palfey, BS Moore. Biochemical Establishment and Characterization of EncM’s Flavin-N5-oxide Cofactor. J. Am. Chem. Soc., 2015, 137, 8078-8085.

R Teufel, A Miyanaga, Q Michaudel, F Stull, G Louie, JP Noel, PS Baran, B Palfey, BS Moore. Flavin-mediated dual oxidation controls and enzymatic Favorskii-type rearrangement. Nature, 2013, 503, 552-556[/expand]

Changhan Lee : Postdoctoral Fellow

Changhan Lee

Postdoctoral Fellow

changhle@umich.edu

Changhan earned his Ph.D. degree at Korea Advanced Institute of Science and Technology (KAIST) in 2012. During his Ph.D. thesis, he characterized the regulatory mechanism to respond reactive electrophilic species (RES) in Escherichia coli. Afterwards, he moved to Karolinska Institute in Sweden as a postdoc and expended his research area to protein quality control system in a key opportunistic human pathogen Pseudomonas aeruginosa. Changhan joined Bardwell lab in 2017 and keeps his deep interest to protein folding and proteostasis. He loves to travel around the world and watch movies.

Zhen Yan : Postdoctoral Fellow

Zhen Yan

Postdoctoral Fellow

Zhen obtained his PhD in the University of Tokyo, working on structure and function of ferredoxin-dependent oxidoreductases from Archaea. Afterwards, he joined in Penn State to work as his first postdoc, study electron transport and energy conservation in acetate-utilizing methanogenic pathway, with the goals of reversing the pathway for biofuels production. Presently, he is working in Bardwell lab as his second postdoc, with the interest of protein folding and chaperon function. Outside of lab, he enjoys doing sports, traveling and reading.

Hyun-hee Kim : Researcher

Hyun-hee Kim

Researcher

Hyun-hee obtained her Ph.D at the Korea Advanced Institute of Science and Technology, where she worked on yeast transcription mechansms based on epigenetics. She moved to the Karolinska Institute in Sweden and studied multicellular behavior in enterobacteriaceae. In the Bardwell lab, she is focusing on a neurodegenerative disorder in yeast model. In her spare time, she enjoys reading, making crafts and playing games.

Dominic Gaetjen : Visiting Scholar

Dominic Gaetjen

Visiting Scholar

dgatjen@umich.edu

Dominic joined the Bardwell lab in July 2015 for a 4-month internship. He studies Biotechnology at the Westphalian Wilhelms-University Münster, Germany with majors in molecular microbiology, enzyme biochemistry and biotechnology of microorganisms.
In his spare time, he enjoys to do sports (soccer, swimming) and playing drums

Serena Rocchio : Visiting Scholar

Serena Rocchio

Visiting Scholar

Serena is an Italian Ph.D. student at Sapienza - University of Rome. Her main scientific interests are in fields of structural biology and molecular medicine. Her Ph.D. work is focused on studying structure-function relationship of proteins involved in microbial infections, in particular by using X-ray crystallography. In the Bardwell lab she is interested in the structural aspects of chaperone-assisted protein folding. Outside the lab, she enjoys doing sports, travelling and reading, as well as arts and music.

Maja Jankovic : Visiting Scholar

Maja Jankovic

Visiting Scholar

Maja studied Medical Biology at the University of Duisburg-Essen with majors in stem cell and cancer biology as well as molecular medicine. After finishing her Master’s thesis in the lab of Prof. Fernando Camargo at the Boston Children's Hospital, and an internship in Novartis, Switzerland she joined the Bardwell lab in August 2017 for an 5-month stay to optimize the protein folding biosensors in yeast and mammalian cell lines, before starting her PhD. Outside the lab, Maja enjoys doing sports and all kinds of outdoor activities, traveling and backpacking.

Agnes Tymieniecki : Graduate Student

Agnes Tymieniecki

Graduate Student

atymieni@umich.edu

Agnes studied Biochemistry and Molecular Biology at the University of Potsdam. After she finished her Master’s thesis in the field of analytically biochemistry, she joined the Bardwell lab for a one-year internship in April 2014. Currently she works on chaperone characterization. In her spare time, Agnes likes to discover new and fun activities, spend time with her friends, travel, participate in sports, and listen to live music.

Luisa Aring : Visiting Scholar

Luisa Aring

Visiting Scholar

Luisa is a visiting scholar from Germany.

Thi Mai Phuong Tran : Visiting Scholar

Thi Mai Phuong Tran

Visiting Scholar

Thi Mai Phuong studies Chemistry at the Free University in Berlin, Germany. In her bachelor thesis she optimized the substrate specificity of amyloid building catalysts to hydrolyze aromatic nitrophenole esters. In September 2017 Thi Mai Phuong joined the Bardwell Lab for a 4-month internship to characterize the structure and functionality of OsmY. In her spare time she enjoys traveling, hiking and watching movies.

Patrick Betschinger : Visiting Scholar

Patrick Betschinger

Visiting Scholar

Patrick is a visiting scholar from Germany.

Franziska Funke : Visiting Scholar

Franziska Funke

Visiting Scholar

Franziska is a visiting scholar from Germany.

Hannah Hipp : Visiting Scholar

Hannah Hipp

Visiting Scholar

hhipp@umich.edu

Hannah studies Biochemistry at the LMU in Munich, Germany and joined the Bardwell lab in August 2016 for a 6-month internship. In her spare time she enjoys doing sports, especially volleyball, spending time with friends and reading.

Sumin Kim : Rotation Student

Sumin Kim

Rotation Student

suminkim@umich.edu

Sumin is a first year graduate student doing a fall rotation in the Bardwell lab. She studied Chemistry at the Massachusetts Institute of Technology, then worked as a research technician for two years doing Alzheimer's-related research. In her spare time, she likes to explore new restaurants, bars, and events with friends, cook, and play or listen to music.

Annika Meiners : Visiting Scholar

Annika Meiners

Visiting Scholar

ameiners@umich.edu

Annika joined the Bardwell lab in June 2016 for a 4-month internship. She studies Biomedical Engineering at the University of Applied Science in Münster, Germany. In her spare time she enjoys swimming, reading and watching soccer games.

May Tsoi : Senior Laboratory Technician

May Tsoi

Senior Laboratory Technician

maydtsoi@umich.edu

May joined the Bardwell lab in November 2015, after working at the University of Michigan for nearly 20 years.  She is a proud mother and soon-to-be grandmother, who enjoys gardening, shopping, and spending time with family.

Chris Sinkler : Lab Manager

Chris Sinkler

Lab Manager

Chris joined the laboratory in December 2016, acting as both lab manager and part-time researcher; his current projects revolve around adapting the tripartite fusion system into mammalian lines, to investigate protein folding in higher order species. He obtained his B.S. in Biochemistry from Michigan State University, and M.S. in Genetics from Wayne State University. This position allows him to combine his interests in management and student support with his background in molecular biology. Outside of the lab, he enjoys cooking, beer, camping/hiking, singing, and taking care of too many cats.

Molly Wysong : Lab Manager

Molly Wysong

Lab Manager

mewysong@umich.edu

Molly attended the University of Michigan as an undergraduate, earning degrees in Evolutionary Anthropology and German.  While studying she worked in genetics labs, and after graduating in May 2014 she worked at Pfizer for a short time before joining the Bardwell lab in April 2015.  Working as a lab manager has offered her a chance to use her affinity for organizing and managing to help further scientific discovery.  In her spare time, Molly enjoys camping, cooking, and her pet parrots.

Sam Kim : Work Study

Sam Kim

Work Study

kimsamc@umich.edu
Jarrett Pennebacker : Work Study

Jarrett Pennebacker

Work Study

pennejar@umich.edu

Jarrett joined the lab in Summer 2015 as a rising junior. He is currently majoring in Chemical Engineering and plans to work in industry upon graduating. Jarrett is from Bradenton, Florida and spends his free time playing soccer, hanging out with friends, and watching Michigan football.

Nick Pennebacker : Work Study

Nick Pennebacker

Work Study

npenneba@umich.edu
Shera Shevin : Work Study

Shera Shevin

Work Study

sheras@umich.edu
Sai Sivakumar : Work Study

Sai Sivakumar

Work Study

saisiva@umich.edu
Darin Wong : Work Study

Darin Wong

Work Study

darinpw@umich.edu

Darin Wong is a rising junior majoring in Program in the Environment. He has a passion for marine and freshwater conservation and hopes to become a marine biologist. He enjoys playing sports and running outdoors, lifting, making music, and reading.

Ji Ye : Work Study

Ji Ye

Work Study

jiye@umich.edu

Ji joined the Bardwell / Jakob Labs as a workstudy Lab Assistant in 2013.

Metasebia Aberra : Visiting Scholar

Metasebia Aberra

Visiting Scholar

mbaberra@umich.edu

Metasebia is a senior pursuing Biochemistry major and Economics minor at Smith College in Northampton, MA. She first became interested in protein folding and stability during her first year when she worked at Smith College as a research assistant studying stabilizing effects of metalloprophyrins on myoglobin derivatives. During 2013 summer, she worked at the University of Leipzig testing the abilities of a plant extract from Ethiopia called Cathinone to cause apoptosis to Lung carcinoma cells. She recently joined Bardwell lab as an HHMI, EXROP student studying the chaperone protein called spy and its ability to bind Zn under the supervision of Scott Horowitz. She aspires to pursue a Ph.D in the future . She enjoys reading, sports, and travelling.

Logan Ahlstrom : Postdoctoral Fellow

Logan Ahlstrom

Postdoctoral Fellow

lsahlstr@umich.edu

Logan’s postdoc research focuses on understanding dynamic protein-protein association, largely in the context of chaperone-substrate interactions. He has developed molecular simulation strategies in close interplay with experiments to achieve detailed biophysical descriptions of flexible chaperone-substrate recognition. In the Bardwell lab, he is working on performing both computational and experimental approaches side-by-side to address questions of chaperone function. Outside of lab, Logan enjoys listening to and watching baseball games, anything active outdoors, reading, home brewing, and jazz.

[expand title="Publications"]
https://sites.google.com/site/lsahlstr/publications[/expand]

Serife (“Sherry”) Akgul : Visiting Scholar

Serife (“Sherry”) Akgul

Visiting Scholar

akguls@umich.edu

Serife or Sherry (nickname which her study colleagues had given her) began her studies in biology with a focus on structural biology/biophysics at the Heinrich-Heine University in Dusseldorf, Germany. She joined the Bardwell lab to finish her Master program by doing her Master thesis. Because she understands herself as a structural biologist, working with chaperons was highly interesting to her. At the moment she works under the supervision of Dr. Scott Horowitz on HdeA a periplasmic E.coli chaperone. Her aim is to characterize a constantly active mutant of HdeA biophysically and structurally.

In her Spare time, Serife loves to join a dance studio near the lab where she is practicing Hip-Hop and Jazz dance. Besides this she enjoy a diversity of activities starting at visiting operas through to doing extreme sports. She is thankful to Prof. Dieter Willbold who makes it possible for her to join the Bardwell lab. She also wants to thank Dr. Matthias Stoldt, Dr. Justin Lecher and Dr. Wolfgang Hoyer, her former supervisors for supporting her. Last but not least, she also want to thank Prof. Bardwell to letting her in Ann Arbor and all her great colleagues in the Bardwell lab.

Brittany Allen : Work Study

Brittany Allen

Work Study

brittall@umich.edu

Brittany joined the lab in Summer 2015 as a rising junior. She is double majoring in Biology and Cognitive Science, with hopes to pursue a career in genetic counseling. Brittany is from Milwaukee, Wisconsin, and enjoys running, playing guitar, and volunteering on the crisis line at Ozone House.

Tobias Baumann : Diploma/Masters Student

Tobias Baumann

Diploma/Masters Student

Tobias is studying Biotechnology at the Technische Universität Braunschweig in Germany. He joined the Bardwell Lab in July 2007 to work on his diploma thesis. He is currently trying to develop an E. coli expression system capable of assessing the folding capabilities of different model proteins. Outside the lab he enjoys hanging out and watching movies with friends as well as playing badminton and volleyball.

Felix Beinlich : Visiting Scholar

Felix Beinlich

Visiting Scholar

beinlich@umich.edu

Felix graduated with his Master’s Degree in biology from the University of Osnabrück in Germany in 2014 with specializations in molecular cell biology and biophysics. He joined the Bardwell Lab in May 2014 for an internship and currently works together with Tsinat Hailu and Agnes Tymieniecki on the discovery of new yeast chaperones. In his spare time, he likes to read, run or hang out with friends.

Austin Cacciaglia : Undergraduate Researcher

Austin Cacciaglia

Undergraduate Researcher

cacciaa@umich.edu

Austin joined the lab as a freshman in Fall 2011. He worked for two years as a lab assistant before beginning research under the supervision of Dr. Chris Lennon in October, 2013. Austin is majoring in Biochemistry and hopes to attend dental school after his undergraduate studies. His hometown of Traverse City, Michigan instilled a love for the outdoors, which he retains in Ann Arbor. Outside of the lab Austin enjoys hiking, cycling, and visiting National Parks.

Claire Cato : Graduate Student

Claire Cato

Graduate Student

catomc@umich.edu

Claire graduated from Vanderbilt University with her B.A. in Molecular and Cellular Biology in May 2014. Throughout her undergraduate career, she studied in a DNA replication and repair lab in the Department of Biological Sciences under Dr. Brandt Eichman. Her research focused on the structure-function relationship of DNA glycosylases, the family of enzymes responsible for DNA damage recognition and initiation of the base excision repair pathway, using crystallographic and biochemical techniques.

Brianne Docter : Graduate Student

Brianne Docter

Graduate Student

bdocter@umich.edu

Brianne is a third year PhD student in the Cell and Molecular Biology program. Currently she works on molecular chaperone discovery. She is originally from Grand Rapids, Michigan and received her bachelor's degree in chemistry from Grand Valley State University. In her spare time, she enjoys reading, baking, biking, crocheting, and spending time with friends.

Tsinatkeab Hailu : Graduate Student

Tsinatkeab Hailu

Graduate Student

tsenat@umich.edu

I graduated with my masters from Vrije Universiteit Amsterdam with specializations in Molecular Cell Biology and Biological Chemistry. I first came to the Bardwell lab in April 2009 to do an internship as part of my master’s program at VU Amsterdam and ended up staying to pursue my PhD as a visiting scholar beginning December 2009. My first project focused on developing a bacterial in vivo assay, using a protein folding biosensor, which can be used to screen chemical/pharmacological chaperones that enhance the stability of proteins. Currently, I am working on developing a similar biosensor on a eukaryotic platform using saccharomyces cerevisiae. In my spare time, I like reading non-science stuff and keeping up to date with current events, watching and playing soccer, swimming and doing anything outdoorsy and making friends.

Christopher W. Lennon : Postdoctoral Fellow

Christopher W. Lennon

Postdoctoral Fellow

clennon@umich.edu

Chris was a postdoctoral researcher in the Bardwell lab who joined the group in May of 2013 after finishing his PhD in Cellular and Molecular Biology at the University of Wisconsin-Madison. His main project is focused on the discovery of unknown chaperones using a direct genetic selection for improved protein folding similar to that previously used to uncover Spy (Quan et al. 2011). When not in lab, Chris likes to organize and participate in dance parties, tickle fights, Spongebob Squarepants marathons, ice cream eating contests... and other adventures with his wife and two kids.
&nbsp
[expand title="Publications"]Lennon CW, Lemmer KC, Irons JL, Sellman MI, Donohue TJ, Gourse RL, Ross W. (January 2014) A Rhodobacter sphaeroides protein mechanistically similar toEscherichia coli DksA regulates photosynthetic growth. mBio. 5(3):e01105-14.
&nbsp
Lennon CW, Ross W, Martin-Tumasz S, Toulokhonov I, Vrentas CE, Rutherford ST, Lee JH, Butcher, Gourse RL. (January 2012) Genes and Development .26:2634-26. PMCID: PMC3521624.
&nbsp
Lee JH, Lennon CW, Ross W, Gourse RL. (January 2012) Role of the coiled-coil tip of Escherichia coli DksA in promoter control. . Journal of Molecular Biology . 416:503-17. PMCID: PMC3288215.[/expand]

Loïc Salmon : Postdoctoral Fellow

Loïc Salmon

Postdoctoral Fellow

lsalmon@umich.edu

Loïc did his Ph.D. in Grenoble, in the heart of the French Alps, under the direction of Martin Blackledge. The core of his work focused on the use of Nuclear Magnetic Resonance (NMR) spectroscopy for characterizing protein dynamics either in folded systems, weak molecular complexes or intrinsically disordered proteins. After graduation in 2011, he joined Dr. Hashim Al-Hashimi's lab in Ann Arbor to investigate the biophysical behavior of nucleic acids. Beginning in 2014, he moved to Dr. James Bardwell's lab and focused his work on pH-activated chaperone proteins, for which conformational flexibility appears to be essential for their biological function.
 
[expand title="Publications"]Ozenne V, Schneider R, Yao M, Huang JR, Salmon L, Zweckstetter M, Jensen MR, Blackledge M. (January 2012) Mapping the Potential Energy Landscape of Intrinsically Disordered Proteins at Amino Acid Resolution. J. Am. Chem. Soc.134:15138-15148. PMID: 22901047.
 
Ozenne V, Bauer F, Salmon L, Huang JR, Jensen MR, Segard S, Bernadó P, Charavay C, Blackledge M. (January 2012) Flexible-Meccano: a Tool for the Generation of Explicit Ensemble Descriptions of Intrinsically Disordered Proteins and their Associated Experimental Observables.Bioinformatics. 28:1463-1470. PMID: 22613562.
 
Salmon L, Pierce L, Grimm A, Ortega Roldan JL, Mollica L, Jensen MR, van Nuland N, Markwick PR, McCammon JA, Blackledge M. (January 2012) Multi-Timescale Conformational Dynamics of the SH3 Domain of CD2-Associated Protein using NMR Spectroscopy and Accelerated Molecular Dynamics.Angew. Chem. Int. Ed. 51:6103-6106. PMCID: PMC3541011.
 
Schneider R, Huang J, Yao M, Communie G, Ozenne V, Mollica L, Salmon L, Jensen MR, Blackledge M. (January 2012) Towards A Robust Description of Intrinsic Protein Disorder using Nuclear Magnetic Resonance Spectroscopy. Mol. BioSyst. 8:58-68. PMID: 21874206.
 
Jensen MR, Ortega-Roldan JL, Salmon L, van Nuland N, Blackledge M. (January 2011) Characterizing Weak Protein-Protein Complexes by NMR Residual Dipolar Couplings. Eur. Biophys. J. 40, 1371-1381. PMID:21710303.
&nbsp
Jensen MR, Communie G, Ribeiro EA, Martinez N, Desfosses A, Salmon L, Mollica L, Gabel F, Jamin M, Longhi S, Ruigrok R, Blackledge M. (January 2011) Intrinsic Disorder in Measles Virus Nucleocapsids. Proc. Natl. Acad. Sci. USA. 108, 9839-9844. PMCID:PMC3116414.
 
Salmon L, Bouvignies G, Markwick P, Blackledge M. (January 2011) Nuclear Magnetic Resonance Provides a Quantitative Description of Protein Conformational Flexibility on Physiologically Important Time Scales. Biochemistry. 50:2735-2747. PMID:21388216.
 
Salmon L, Roldan JL, Lescop E, Van Nuland N, Jensen M, Blackledge M. (January 2011) Structure, Dynamics and Kinetics of Weak Protein-Protein Complexes from NMR Spin Relaxation Measurements of Titrated Solutions. Angew. Chem. Int. Ed. 50:3755-3759. PMID:21425222.
 
Salmon L, Nodet G, Ozenne V, Yin G, Jensen MR, Zweckstetter M, Blackledge M. (January 2010) J. Am. Chem. Soc. 132: 8407-8418. PMID:20499903.
 
Jensen MR, Salmon L, Nodet G, Blackledge M. (January 2010) Defining Conformational Ensembles of Intrinsically Disordered and Partially Folded Proteins Directly from Chemical Shifts. J. Am. Chem. Soc. 132(4): 1270-1271. PMID:20063887.
 [/expand]

Julia Daiss :

Julia Daiss

jldaiss@umich.edu

Julia is an undergrad student of Molecular Medicine at the University of Regensburg, Germany. She first heard of chaperones in her first semester nearly two years ago and directly got interested in it. Hence she is very happy to be able to join the Bardwell lab for a 10-week internship in cooperation with the DAAD RISE program. Therefore, she wants to thank everyone who made this possible, especially Prof. Bardwell. Currently she is working with biosensors in order to observe protein stability and–if she is lucky–new chaperones may be detected. In her spare time, she loves being outdoors, as well as travelling. Moreover, she likes to spend her time with friends and playing soccer.

Timothy Fernandez : Postdoctoral Fellow

Timothy Fernandez

Postdoctoral Fellow

timfern@umich.edu

Tim is a first year medical student at the University of Alabama School of Medicine in Birmingham, AL. He graduated from the University of Alabama at Birmingham with a dual Bachelor’s Degree in Biochemistry and Molecular Biology. Under the direction of Dr. Jamil Saad, he studied the underlying structural basis by which HIV proteins interact with cellular constituents during the virus replication. Additionally, he investigated the structural determinants of Fas-CaM interaction, in order to understand the precise molecular mechanism of Fas-mediated apoptosis and mechanism of inhibition. In the summer 2014, Tim joined the Bardwell Lab as an HHMI Summer Medical Fellow. He is currently using biophysical methods, such as isothermal titration calorimetry, as a way to quantify chaperone protein activity. In his spare time, he likes to watch football and play table tennis.

Joel Chamness : Work Study

Joel Chamness

Work Study

joelcham@umich.edu
Elias Friman : Visiting Scholar

Elias Friman

Visiting Scholar

tefriman@umich.edu

Elias is studying Medical Biotechnology the Royal Institute of Technology (Stockholm, Sweden). He joined the Bardwell lab to do research for his master's thesis and is working with Chris Lennon on chaperone characterization.

Stefan Gleiter, Ph.D. : Postdoctoral Fellow

Stefan Gleiter, Ph.D.

Postdoctoral Fellow

sgleiter@gmail.com

Stefan studied biochemistry at the Martin-Luther-Universität Halle/Saale in Germany. He did his Ph.D. thesis under the supervision of Hauke Lilie in the lab of Rainer Rudolph. There he worked on the development of a new, non-viral vector system for gene therapy based on an engineered and recombinant produced viral coat protein. He joined the Bardwell lab in June 2003 to work on DsbA, an oxidorecuctase in the periplasm of E.coli. His main task is to elucidate how DsbA binds substrates and DsbB and how DsbA distinguishes between these two proteins. In order to do this, he combines genetic approaches as well as protein chemistry and structural biology. Recently Stefan discovered that jumping out of airplanes from 13,000 feet AGL is a way to spend time outside of the lab. Other than that he likes every kind of sport where a ball is involved and many different outdoor activities.
 
[expand title="Publications"]
Foit L, Mueller-Schickert A, Mamathambika BS, Gleiter S, Klaska CL, Ren G, Bardwell JC. (2011) Genetic selection for enhanced folding in vivo targets the Cys14-Cys38 disulfide bond in bovine pancreatic trypsin inhibitor. Antioxid Redox Signal. 14(6):973-84. (Pubmed)
 
Gleiter S, Bardwell JC.. (2008) Disulfide bond isomerization in prokaryotes. Biochim Biophys Acta. 1783(4):530-4. (Pubmed)
 
Tapley TL, Eichner T, Gleiter S, Ballou DP, Bardwell JC. (2007) Kinetic characterization of the disulfide bond-forming enzyme DsbB. J Biol Chem. 282(14):10263-71. (Pubmed)
 
Goulding CW, Apostol MI, Gleiter S, Parseghian A, Bardwell J, Gennaro M, and Eisenberg D. (2003) Gram-positive DsbE proteins function differently from gram-negative DsbE homologs: A structure function analysis of DsbE from Mycobacterium tuberculosis. J. Biol. Chem. 2004 Jan 30;279(5):3516-24. Epub 2003 Nov 3. (Pubmed) [/expand]

Jacqueline Gusmann : Research Associate

Jacqueline Gusmann

Research Associate

jgusmann@umich.edu

Jacqueline did her Master’s Degree in Bremen at the University of Applied Sciences under the direction of Prof. Tilman Achstetter. Her work focused on factors affecting yeast transformation. Therefore an optimized lithium acetate transformation protocol of Saccharomyces cerevisiae with recombinant multicopy plasmids was established. After graduation she joined Dr. James Bardwell´s lab for an internship between September 2014- .

Lananh Ho : Work Study

Lananh Ho

Work Study

laho@umich.edu

Lananh joined the Bardwell / Jakob Labs as a workstudy Lab Assistant in 2012. She’s a Chemical Engineering major.

Sarah Lambrecht : Visiting Scholar

Sarah Lambrecht

Visiting Scholar

lambrech@umich.edu

Sarah joined the Bardwell lab in August 2015 for a research internship. She obtained her master degree in biochemistry and microbiology at the Georg-August University and the Max Planck Institute for Biophysical Chemistry in Göttingen. In her free time Sarah enjoys board gaming, nature, cycling, reading and looking at cute animals.

Raoul Martin : Undergraduate Researcher

Raoul Martin

Undergraduate Researcher

raolmart@umich.edu

Raoul is a Junior majoring in Biochemistry at the University of Michigan. He is originally from Marseille, France. Raoul joined our lab in Winter 2012 as a laboratory assistant. In the beginning of October 2012, he became a research assistant under the supervision of Philip Koldewey. His main interests are protein kinetics, structural biology and protein engineering. He is also the vice-president of the Michigan Synthetic Biology Team. He aspires to join a graduate program and earn a PhD.

Jimi Nguyen : Work Study

Jimi Nguyen

Work Study

jlocn@umich.edu

Jimi Nguyen is a recent graduate of the University of Michigan School of Music, Theater and Dance from Cutlerville, Michigan. Jimi is part of Encore, a co-ed hip-hop dance team, and is very active with many other performing arts groups. He hopes to move to Chicago at the end of Summer 2015.

Jessica Raisanen : Work Study

Jessica Raisanen

Work Study

raisanej@umich.edu

Jessica graduated from The University of Michigan with her Bachelor of Science in May of 2015 with a double concentration in Biopsychology, Cognition, and Neuroscience (BCN) and Women's Studies. During the spring and summer of this year, she is working at the Bardwell lab as a Research Associate on a project about algae, diatoms, and pollution. She will be leaving Ann Arbor in the fall and moving to Baltimore, MD for graduate school at Johns Hopkins Bloomberg School of Public Health where she will be pursuing her Master of Science in Public Health through the Department of Population, Family, and Reproductive Health. In her free time, Jessica enjoys rock climbing, Netflix, and creative writing.

Collin Rush : Undergraduate Researcher

Collin Rush

Undergraduate Researcher

rushco@umich.edu

Collin is from Northville, Michigan and is a recent graduate of the University of Michigan.  He will be attending Wayne State University's School of Medicine in Fall 2015.

Antje Schickert : Visiting Scholar

Antje Schickert

Visiting Scholar

antjem@umich.edu

Antje studied biology at the University in Tuebingen, Germany, where she graduated with a major in cell biology/immunology. After she finished her diploma thesis at the Friedrich-Loeffler-Institute, she joined the Bardwell lab in September 2009 to work on her PhD thesis.

Currently she is working on developing a genetic system which allows studying protein folding in vivo.

In her spare time Antje enjoys playing ice hockey, plays the guitar and loves the outdoors.

Stefanie Schmidt : Graduate Student

Stefanie Schmidt

Graduate Student

Stefanie studied biology at the Johan-Wolfgang-Goethe University in Frankfurt, Germany. Her majors were microbiology, ecology& evolution and genetics. She joined the Bardwell lab in October 2005. First Steffie worked on the question: if GSH is directly involved in disulfide bond formation. Currently, she wants to figure out in which environment the active site of DsbA is functional. Outside the lab Steffie likes going to the cinema, meeting friends, sometimes partying and going to the gym.
 
[expand title="Publications"]
Evans ML, Schmidt JC, Ilbert M, Doyle SM, Quan S, Bardwell JC, Jakob U, Wickner S, Chapman MR. (2012) E. coli chaperones DnaK, Hsp33, and Spy inhibit bacterial functional amyloid assembly. Prion. 1;5(4). (Pubmed) [/expand]

James (Jae) Park : Work Study

James (Jae) Park

Work Study

orcapark@umich.edu

James has been working in the Bardwell / Jakob Labs as a workstudy Lab Assistant since 2013.

Blair Whittington : Undergraduate Researcher

Blair Whittington

Undergraduate Researcher

blairjw@umich.edu

Blair has worked with Logan as part of the University of Michigan Undergraduate Research Opportunity Program since Fall 2014. Blair first used computer simulations to study protein-protein recognition. She is now learning experimental techniques in order to address questions pertaining to chaperone-substrate interactions. Blair is currently a sophomore taking courses with a focus on biochemistry and molecular biology.

Joyce Xia : Work Study

Joyce Xia

Work Study

xjoyce@umich.edu

Joyce joined the lab as a rising sophomore in August 2015. She is a Neuroscience major and hopes to attend medical school after graduation. In her free time, Joyce likes to fence and watch Netflix.