Lab Members – Bardwell Lab

Lab Members

James C. Bardwell, Ph.D. : Rowena G. Matthews Collegiate Professor, MCDB<br>HHMI Investigator

James C. Bardwell, Ph.D.

Rowena G. Matthews Collegiate Professor, MCDB<br>HHMI Investigator

Howard Hughes Medical Investigator

Department of Molecular Cellular Developmental Biology

Program in Cellular Molecular Biology

Department of Biophysics

Awards and Fellowships

2013 AAAS Fellow
2009 Rowena G. Matthews Collegiate Professorship
2005 HHMI Investigator
1999 Literature, Science and Arts Excellence in Research Award
1997-2001 Pew Scholar
1993-1995 Alexander von Humboldt Fellowship
1989-1993 Helen Hay Whitney Fellowship
1981-1985 NSERC Postgraduate Scholarship

jbardwel@umich.edu
Xiexiong Deng : Postdoctoral Fellow

Xiexiong Deng

Postdoctoral Fellow

Xiexiong attained his PhD at Michigan State University in 2018, where he studied the mitotic function of histone H3 in budding yeast. Afterwards, he joined Bardwell lab and studies amyloidogenic protein folding using budding yeast. Outside the lab, he loves watching soccer and playing badminton.

dengx@umich.edu
Ee Lin Wong : Postdoctoral Researcher

Ee Lin Wong

Postdoctoral Researcher

A normal girl who enjoys travelling and playing ukulele, picking up new languages, and is a solid K-pop fan.

eelinw@umich.edu
Bikash Sahoo : Postdoctoral Researcher

Bikash Sahoo

Postdoctoral Researcher

bsahoo@umich.edu
Mark Dulchavsky : Graduate Student

Mark Dulchavsky

Graduate Student

Mark graduated from the University of Michigan majoring in Biophysics and minoring in music. His previous research includes work in linguistics analysis and neurodegenerative disease. He joined the U of M MD PhD program in 2017 and then the Bardwell lab in 2019. Currently, he works on protein engineering of biotherapeutic enzymes. Outside of lab, Mark enjoys hobbyist electronics and music performance.

Kevin Wu : Graduate Student

Kevin Wu

Graduate Student

Kevin received his Master degree in biochemistry and molecular biology from National Taiwan University in 2015. His master’s thesis research was using structure-based approaches to study the activation mechanism of deubiquitinase. He joined Bardwell lab in January 2017. Currently, he is studying the kinetic folding mechanism of chaperone and revealing how a chaperone interacts with its client proteins. Outside the lab, he enjoys playing tennis and watching TV series.

Rishav Mitra : Graduate Student

Rishav Mitra

Graduate Student

Rishav received his master’s degree in biotechnology from St. Xavier’s College (Autonomous) Kolkata affiliated to the University of Calcutta, India. He joined the Bardwell Lab in 2018. Currently, he is focussing on finding a biophysically amenable chaperone-substrate pair to understand mechanisms of chaperone- assisted protein folding. Outside of lab, Rishav enjoys listening to classical music and watching movies.

Hannah Navarrete : Graduate Student

Hannah Navarrete

Graduate Student

Hannah graduated from the University of California, Riverside (UCR) in 2019 with a B.S. in Biochemistry. While at UCR, she looked at HNF4 stability in the presence of oxylipins, which are formed in the liver from unsaturated fatty acids. After graduating, Hannah spend a year as a PREP scholar at the Johns Hopkins School of Medicine, where she screened for sex biased gene expression in a population of "support cells" in the gonads. She came to Michigan as a PIBS student in MCDB and joined the Bardwell lab in 2021. Outside of lab, she enjoys knitting and spending time outdoors.

hnava@umich.edu
Chris Sinkler : Lab Manager

Chris Sinkler

Lab Manager

Chris joined the laboratory in December 2016, acting as both lab manager and part-time researcher; his current projects revolve around adapting the tripartite fusion system into mammalian lines, to investigate protein folding in higher order species. He obtained his B.S. in Biochemistry from Michigan State University, and M.S. in Genetics from Wayne State University. This position allows him to combine his interests in management and student support with his background in molecular biology. Outside of the lab, he enjoys cooking, beer, camping/hiking, singing, and taking care of too many cats.

sinklerc@umich.edu
Traci Banjanin : Senior Lab Technician

Traci Banjanin

Senior Lab Technician

Traci earned a BS in biochemistry from MSU and a M.Ed. in educational leadership from WSU. After a 30year career as a chemistry teacher, Traci retired and joined the Bardwell lab in Feb 2021. She is enjoying supporting the research efforts of all in the lab. Outside of work, Traci likes to kayak and boat, bike, read and cook.

banjanin@umich.edu
Ken Wan : Senior Laboratory Technician

Ken Wan

Senior Laboratory Technician

Ken has worked as a lab technician at U of M for nearly ten years. He joined the Bardwell lab from an HHMI lab in June 2013. Ken’s work is mainly on protein expression and purification. His work consists of making all kinds of constructs for E. coli, Baculovirus insect cell and yeast systems as well as purifying proteins with or without tags using the AKTA system. He enjoys screening and optimizing the protein crystals as well. Ken likes traveling, swimming and fishing.

Publications


Wan B, Yin J, Horvath K, Sarkar J, Chen Y, Wu J, Wan K, Lu J, Gu P, Yu EY, Lue NF, Chang S, Liu Y, Lei M. (September 2013) SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. Cell Rep. 4(5):861-9. doi: 10.1016/j.celrep.2013.08.017. Epub 2013 Sep 5. PMID: 24012755.

Huang J, Gurung B, Wan B, Matkar S, Veniaminova NA, Wan K, Merchant JL, Hua X, Lei M. (February 2012) The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature. 482(7386):542-6. doi: 10.1038/nature10806. PMID: 22327296.

Sun J, Yang Y, Wan K, Mao N, Yu TY, Lin YC, DeZwaan DC, Freeman BC, Lin JJ, Lue NF, Lei M. (February 2011) Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase α. Cell Res. 21(2):258-74. doi: 10.1038/cr.2010.138. Epub 2010 Sep 28. PMID: 20877309.

Sun J, Yu EY, Yang Y, Confer LA, Sun SH, Wan K, Lue NF, Lei M. (December 2009) Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev.23(24):2900-14. doi: 10.1101/gad.1851909. PMID: 20008938

kewan@umich.edu

Previous Lab Members

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