Lab Members

James C. Bardwell, Ph.D. : Rowena G. Matthews Collegiate Professor, MCDB<br>HHMI Investigator

James C. Bardwell, Ph.D.

Rowena G. Matthews Collegiate Professor, MCDB
HHMI Investigator

Howard Hughes Medical Investigator

Department of Molecular Cellular Developmental Biology

Program in Cellular Molecular Biology

Department of Biophysics

Awards and Fellowships

2013 AAAS Fellow
2009 Rowena G. Matthews Collegiate Professorship
2005 HHMI Investigator
1999 Literature, Science and Arts Excellence in Research Award
1997-2001 Pew Scholar
1993-1995 Alexander von Humboldt Fellowship
1989-1993 Helen Hay Whitney Fellowship
1981-1985 NSERC Postgraduate Scholarship

jbardwel@umich.edu
Ricky Stull : Postdoctoral Fellow

Ricky Stull

Postdoctoral Fellow

Ricky is from Florida. He received his PhD at the University of Michigan, where he studied the reaction mechanisms of flavin-dependent enzymes. In the Bardwell lab, he studies the mechanism of chaperone activation and function. Outside of lab, he enjoys cycling, baseball, and homebrewing.

Publications

R Teufel, F Stull, MJ Meehan, Q Michaudel, PC Dorrestein, B Palfey, BS Moore. Biochemical Establishment and Characterization of EncM’s Flavin-N5-oxide Cofactor. J. Am. Chem. Soc., 2015, 137, 8078-8085.

R Teufel, A Miyanaga, Q Michaudel, F Stull, G Louie, JP Noel, PS Baran, B Palfey, BS Moore. Flavin-mediated dual oxidation controls and enzymatic Favorskii-type rearrangement. Nature, 2013, 503, 552-556

fstull@umich.edu
Changhan Lee : Postdoctoral Fellow

Changhan Lee

Postdoctoral Fellow

Changhan earned his Ph.D. degree at Korea Advanced Institute of Science and Technology (KAIST) in 2012. During his Ph.D. thesis, he characterized the regulatory mechanism to respond reactive electrophilic species (RES) in Escherichia coli. Afterwards, he moved to Karolinska Institute in Sweden as a postdoc and expended his research area to protein quality control system in a key opportunistic human pathogen Pseudomonas aeruginosa. Changhan joined Bardwell lab in 2017 and keeps his deep interest to protein folding and proteostasis. He loves to travel around the world and watch movies.

changhle@umich.edu
Zhen Yan : Postdoctoral Fellow

Zhen Yan

Postdoctoral Fellow

Zhen obtained his PhD in the University of Tokyo, working on structure and function of ferredoxin-dependent oxidoreductases from Archaea. Afterwards, he joined in Penn State to work as his first postdoc, study electron transport and energy conservation in acetate-utilizing methanogenic pathway, with the goals of reversing the pathway for biofuels production. Presently, he is working in Bardwell lab as his second postdoc, with the interest of protein folding and chaperon function. Outside of lab, he enjoys doing sports, traveling and reading.

Hyun-hee Kim : Researcher

Hyun-hee Kim

Researcher

Hyun-hee obtained her Ph.D at the Korea Advanced Institute of Science and Technology, where she worked on yeast transcription mechansms based on epigenetics. She moved to the Karolinska Institute in Sweden and studied multicellular behavior in enterobacteriaceae. In the Bardwell lab, she is focusing on a neurodegenerative disorder in yeast model. In her spare time, she enjoys reading, making crafts and playing games.

Ben Meinen : Graduate Student

Ben Meinen

Graduate Student

Ben Meinen is a first year Phd student in the Bardwell Lab. He is from Duesseldorf in Germany. He obtained his Master degree with focus on protein biochemistry from Martin-Luther-University Halle-Wittenberg in October 2014.  He is interested in biophysical protein characterization and protein folding in vitro and in vivo. Outside the lab he enjoys to do sports, travelling and tasting crafted beer. At this point he wants to thank PD Dr. Hauke Lilie for his support and the opportunity to join the Bardwell lab.

benalex@umich.edu
Veronika Sachsenhauser : Graduate Student

Veronika Sachsenhauser

Graduate Student

Veronika began her PhD in the Bardwell lab in 2015 after she obtained her M.Sc. in Molecular Biotechnology from the Technical University Munich, Germany. In her PhD project she focuses on establishing a genetic selection system in Saccharomyces cerevisiae. Outside of lab, Veronika enjoys any kind of outdoor activities, traveling and reading.

vsachsen@umich.edu
Kevin Wu : Graduate Student

Kevin Wu

Graduate Student

Kevin received his Master degree in biochemistry and molecular biology from National Taiwan University in 2015. His master’s thesis research was using structure-based approaches to study the activation mechanism of deubiquitinase. He joined Bardwell lab in January 2017. Currently, he is studying the kinetic folding mechanism of chaperone and revealing how a chaperone interacts with its client proteins. Outside the lab, he enjoys playing tennis and watching TV series.

Rishav Mitra : Graduate Student

Rishav Mitra

Graduate Student

Rishav received his master’s degree in biotechnology from St. Xavier’s College (Autonomous) Kolkata affiliated to the University of Calcutta, India. He joined the Bardwell Lab in 2018. Currently, he is focussing on finding a biophysically amenable chaperone-substrate pair to understand mechanisms of chaperone- assisted protein folding. Outside of lab, Rishav enjoys listening to classical music and watching movies.

Chris Sinkler : Lab Manager

Chris Sinkler

Lab Manager

Chris joined the laboratory in December 2016, acting as both lab manager and part-time researcher; his current projects revolve around adapting the tripartite fusion system into mammalian lines, to investigate protein folding in higher order species. He obtained his B.S. in Biochemistry from Michigan State University, and M.S. in Genetics from Wayne State University. This position allows him to combine his interests in management and student support with his background in molecular biology. Outside of the lab, he enjoys cooking, beer, camping/hiking, singing, and taking care of too many cats.

sinklerc@umich.edu
May Tsoi : Senior Laboratory Technician

May Tsoi

Senior Laboratory Technician

May joined the Bardwell lab in November 2015, after working at the University of Michigan for nearly 20 years.  She is a proud mother and soon-to-be grandmother, who enjoys gardening, shopping, and spending time with family.

maydtsoi@umich.edu
Ken Wan : Senior Laboratory Technician

Ken Wan

Senior Laboratory Technician

Ken has worked as a lab technician at U of M for nearly ten years. He joined the Bardwell lab from an HHMI lab in June 2013. Ken’s work is mainly on protein expression and purification. His work consists of making all kinds of constructs for E. coli, Baculovirus insect cell and yeast systems as well as purifying proteins with or without tags using the AKTA system. He enjoys screening and optimizing the protein crystals as well. Ken likes traveling, swimming and fishing.

Publications


Wan B, Yin J, Horvath K, Sarkar J, Chen Y, Wu J, Wan K, Lu J, Gu P, Yu EY, Lue NF, Chang S, Liu Y, Lei M. (September 2013) SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. Cell Rep. 4(5):861-9. doi: 10.1016/j.celrep.2013.08.017. Epub 2013 Sep 5. PMID: 24012755.

Huang J, Gurung B, Wan B, Matkar S, Veniaminova NA, Wan K, Merchant JL, Hua X, Lei M. (February 2012) The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature. 482(7386):542-6. doi: 10.1038/nature10806. PMID: 22327296.

Sun J, Yang Y, Wan K, Mao N, Yu TY, Lin YC, DeZwaan DC, Freeman BC, Lin JJ, Lue NF, Lei M. (February 2011) Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase α. Cell Res. 21(2):258-74. doi: 10.1038/cr.2010.138. Epub 2010 Sep 28. PMID: 20877309.

Sun J, Yu EY, Yang Y, Confer LA, Sun SH, Wan K, Lue NF, Lei M. (December 2009) Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev.23(24):2900-14. doi: 10.1101/gad.1851909. PMID: 20008938

kewan@umich.edu

 

Previous Lab Members