Lab Publications

(2007- present; after moving to Michigan; featured publications in red)

1. Du, W., Gu, M., Hu, M., Pinchi, P., Chen, W., Ryan., M, Nold, T., Bannaga, A., and Xu H (2021). Lysosomal release triggers mitochondria-mediated non-apoptotic cell death in metastatic melanoma. Cell Reports (in press).

2. Yue, L, and Xu H (2021).  TRP channels in health and disease at a glance. J. Cell Sci. 2021 Jul 1;134(13):jcs258372. doi: 10.1242/jcs.258372. Epub 2021 Jul 13.

3. Zhang W, Yang X, Chen L, Liu YY, Venkatarangan V, Reist L, Hanson P, Xu H, Wang Y, Li M (2021). A conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation. PloS Biol. 2021 Jul 23;19(7):e3001361. doi: 10.1371/journal.pbio.3001361.

4. Li, P., Hu, M. *, Wang, C. *, Feng, X., Zhao, Z., Yang, Y., Sahoo, N., Gu, M., Xiao, S., Sah, R., Cover, T., Geha, R., and Xu H (2020).  An osmo-sensitive ion channel in the lysosome.  PNAS  2020 Nov 17;117(46):29155-29165.

5.Li, D., Shao, R.Wang, N., Zhang, X., and Xu H (2020) a lysosome-dependent transcriptional program to mitigate oxidative Stress.   Autophagy 2020 Mar 15;1-16. doi: 10.1080/15548627.2020.1739442. 

6. Yu, L., Zhang, X., Yang, Y., Li, D., Tang, K., He., W, Wang, C., Sahoo, N., Davis, C., Brooks, S.  Bigot, A., Calvo., R., Marugan, J., Ferrer, M., and Xu H (2020).  Small molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models. Science Advances  2020, Feb 7;6(6):eaaz2736. doi: 10.1126/sciadv.aaz2736.

7. Zhang, X. *, Chen, W. *, Li, P. *, Calvo, R., Southall, N., Hu, X., Feng, X., Geng, Q., Gao, C., Yang, M., Tang, K.,  Ferrer, M., Marugan, J., and Xu H (2019).  Agonist-specific Voltage-dependent Gating of Lysosomal Two-pore Na+ Channels. eLife. PDF.     

8. Minckley T., Zhang, C., Fudge, D., Dischler, A., LeJeune, K.,Xu H and, Qin, Y. (2019). Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals . Nature Communications. 2019 Oct 22;10(1):4806. doi: 10.1038/s41467-019-12761-x.

9. Zhang X., Gu, M., Hu, M., Yang, Y.,and Xu H (2019).Endosomal and lysosomal electrophysiology. “Ion and Molecule Transport in Lysosomes” Book—CRC Methods in Signaling Transduction Series (in press).

10.Xin, Y., Malick, A., Hu, M.,,Liu, C., Batah, H., Xu, H. and, Duan C., (2019). Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6 . eLife. Sep 17;8. pii: e48003. doi: 10.7554/eLife.48003. [Epub ahead of print]

11. Zhang, X., Chen., W., Gao, Q., Yang, J., Yan, X., Zhao., H,., Lin, S., Yang, M., Chen, G., Yao,. Y, Inoki, K, Li, D. Shao, R., Wang, S., Sahoo, N., Kudo, F., Egguchi, T., Ruan, B.,and, Xu H (2019). Rapamycin Directly Activates Lysosomal Mucolipin TRP Channels Independent of mTOR. PloS Biol. May 21;17(5):e3000252. doi: 10.1371/journal.pbio.3000252. eCollection 2019 May. PDF

11. Li, P., Gu, M., and, Xu H (2018). Lysosomal Ion Channels As Decoders of Cellular Signals. Trends in Biochemical Sciences. Feb;44(2):110-124. doi: 10.1016/j.tibs.2018.10.006. Epub 2018 Nov 10. PDF

12. Zhang, X., Hu, M., Yang, Y.,and, Xu H (2018).Organellar TRP Channels . Nat. Struct. Mol. Biol. Nov;25(11):1009-1018. doi: 10.1038/s41594-018-0148-z. Epub 2018 Oct 29. PDF

13.Wang, Z., Ocadiz-Ruiz, R., Sundaresan, S., Ding, L., Hayes, M., Sahoo, N., , Xu, H., and, Merchant JL(2018). Isolation of enteric glial cells from the submucosa and lamina propria of the adult mouse . J. Vis. Exp. 2018 Aug 15;(138). doi: 10.3791/57629.

14 .Yang, J., Zhao., Z., Gu, M., Feng, X., and, Xu H (2018). Release and uptake mechanisms of vesicular Ca2+ stores . Protein & Cell Mar 16. doi: 10.1007/s13238-018-0523-x.

15. Chen Q, She J, Zeng W, Guo J, Xu H, Bai XC, Jiang Y. Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature. 2017 Oct 11. doi: 10.1038/nature24035. [Epub ahead of print].

16. Sundaresan S, Meininger CA, Kang AJ, Photenhauer AL, Hayes MM, Sahoo N, Grembecka J, Cierpicki T, Ding L, Giordano TJ, Else T, Madrigal DJ, Low MJ, Campbell F, Baker AM, Xu H, Wright NA, Merchant JL. Gastroenterology ( 2017). Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells. Aug 28. pii: S0016-5085(17)36071-7. doi: 10.1053/j.gastro.2017.08.038. [Epub ahead of print]

17 Sahoo, N., Gu, M., Zhang, X., Raval, N., Yang, J., Bekier, M., Calvo, R.,Patnaik, S., Wang, W., King, G., Samie, M., Gao, Q., Sahoo, S., Sundaresan, S., Kelly, T., Wang, Y., Marugan, J., Ferrer, M., Samuelson, L., Merchant, J., and Xu, H.  (2017). A Ca(2+) efflux channel in the tubolovesicle.  Developmental Cell. 2017 May 8;41(3):262-273.e6. doi: 10.1016/j.devcel.2017.04.003. PDF 

18. Wang, W., Zhang, X., Gao, Q., Cheng, X., Lawas, M., Sahoo N., Meredith M., and Xu, H. (2017). A K+ channel in the lysosome is required for store refilling.  J. CellBiol.  May 3. pii: jcb.201612123. doi: 10.1083/jcb.201612123. [Epub ahead of print]. PDF

19. Hirano, T., Stecker, K., Munnik, T., Xu, H., and Sato M.  (2017) Plant and Cell Physiology. . Visualization of phosphatidylinositol 3,5-bisphosphate dynamics by tandem ML1N-based fluorescent protein probe in Arabidopsis. 2017 Jan 31. doi: 10.1093/pcp/pcx011

20 Gu, M., and Xu, H.  (2016) Journal of Cell Biology. A painful TR(i)P to lysosomes. Nov 7;215(3):309-312 . PDF

21 Krishna, S., Palm, W., Lee, Y., Yang, W.,  Bandyopadhyay, U., Xu, H.,  Oliver Florey, O,  Thompson, C, and  Overholtzer, M.. (2016) Dev. Cell. PIKfyve regulates vacuole maturation and nutrient recovery following engulfment. Sep 12;38(5):536-47. doi: 10.1016/j.devcel.2016.08.001.

22. Zhang, X., Lu, Yu, and Xu, H. (2016). Lysosome Calcium in ROS Regulation of Autophagy.. AutophagyOct 2;12(10):1954-1955. PDF

23. Garrity, A., Wang, X, Collier C.M.D, Levey, S.A., Gao, Q., and Xu, H. (2016). The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes. eLife2016 May 23;5. pii: e15887. doi: 10.7554/eLife.15887. PDF

24. Zhang, X.Cheng, X., Yu, L., Yang, J., Calvo, R., Patnaik, S., Hu, X., Gao, Q., Yang, M., Lawas, M.,Delling, M., Marugan, J., Ferrer, M., and Xu, H. (2016) ROS sensor in lysosomes that regulates autophagy. Nature Communications. 2016 Jun 30;7:12109. doi: 10.1038/ncomms12109. PDF

25. Li.X., Rydzewski, N., Hider., A., Zhang, X., Yang, J., Wang. W., Gao., Cheng., X., and Xu, H. . (2016) A Molecular Mechanism to regulate lysosome positioning. Nat. Cell. Biol. 2016.  PDF

26. Cheng., X., Zhang, X., Yu, L., and Xu, H. . (2015) Ca2+ signaling in membrane repair. Seminars in Cell and Developmental Biology(invited review). 2015 Sep; 45;24-3.  

27. Miao Y., Li, G., Zhang, X., Xu, H., and Abraham SN. (2015) A TRP channel senses lysosome neutralization by pathogens to trigger their expulsion. Cell. 2015 Jun 4;161(6):1306-19. 

28 Xu, H., Martinoia E., and Szabo I. (2015) Organellar Channels and Transporters. Cell Calcium. 2015 Jul 1;58(1):1-10. PDF

29. Wang, W., Gao, Q., Yang, M., Zhang, X., Yu, L., Lawas, M., Li, X., Bryant-Genevier, M., Southall, N., Marugan, J., Ferrer, M., and Xu, H. (2015). TRPML1 channels in lysosomal adaptation to nutrient starvation.  PNAS Plus PDF

30. Medina, L.M., Di Paola, S., Peluso, I., Armani, A., De Stefani, D., Ventiti, R., Montefusco, S., Scotto-Rosata, A., Presioso, C., Forrester, A., Settermbre, C., Wang, W., Gao, Q.Xu, H., Sandri, M., Rizzuto, R., De Matteis, M., and Ballabio. (2015). Lysosomal calcium signaling regulates autophagy .  Nat. Cell. Biol. 2015 Mar;17(3):288-99.

31.  Xu, H and Ren D. (2015) Lysosomal Physiology. Annual Review in Physiology. 2015 Feb. 10; 77: 57-80  PDF

32. Qiong G., Zhang X., and Xu, H (2014). TRPML channels: Handbook of Ion press.

33.Cheng, X., Zhang, X., Gao, Q., Azar, M., Tsang, W.L., Dong, L., Samie, M., Li, X., Zhuo, Y., Garrity, A., Wang, X., Ferrer, M., Dowling, J., Xu, L., Han, R., and Xu, H. (2014) An Intracellular Ca2+ Channel is Required For Sarcolemma Repair to Prevent Muscular Dystrophy. Nature Medicine. Epub Sept. 14   PDF

34 Bae M, Patel N, Xu H, Lee M, Nath A, Geiger J, Gorospe M, Mattson MP, and Haughey NJ ( 2014). Activation of TRPML1 clears intraneuronal Aβ in preclinical Models of HIV infection. Journal of Neurosceicne. Aug. 20; 34(34): 11485-503.

35. Samie, M., and Xu, H. (2014) Lysosomal exocytosis and lipid storage disorders. Journal of Lipid Research (Invited review). March 25; 55.  PDF

36. Sun Y., Yong K., Villa-Diaz, L, Zhang, X., Chen, W., Philson, R., Weng, S., Xu H., Krebsbach,P., and Fu, J (2014). Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells. Nature Materials (2014). Jun. 599-604

37. Li, X., Wang, X. , Zhang, X. Tsang, W.L, ,Zhao, M., Zhang, Y., Yau R.W., Weisman, LS., and  Xu, H. (2013) A Genetically-encoded Fluorescent probe to visulize intracellualr PI(3,5)P2 localization and dynamics. PNAS (Epub 2013 Dec. 11).  PDF

38 Samie, M., Wang, X. , Zhang, X. ,Goschka, A.,Li, X., Cheng, X., Gregg, E., Azar, M., Zhuo, Y., Garrity, AG,,Gao, Q., Slaugnehaupt, S, Pickel, J., Zolov, S., Weisman, LS., Lenk, G., Titus, S., Bryant-Genevier, M., Southall, N., Juan, M., Ferrer, M., and  Xu, H. (2013) A TRP channel in the lysosome regulates focal exocytosis.  Developmental Cell. Sep 16;26(5):511-24. doi: 10.1016/j.devcel.2013.08.003. Epub 2013 Aug 29.).   PDF

39. Wang W., Zhang, X., Gao, Q., and Xu, H. (2013) TRPML1: an ion channel in the Lysosome. Handbook of Experimental Pharmacology HEP222:631-45..

40. Li, X., Garrity A.G, and Xu, H. (2013) Regulation of membrane trafficking by signaling on endosomal and lysosomal membranes. Topical Review. Journal of Physiology. (ePub July 22, 2013). PDF

41. Wang, X. *, Zhang, X. *, Dong, X., Samie, M., Li, X., Cheng, X., Goschka, A., Shen., D.,  Zhou, Y., Harlow, J., Zhu, M.X., Clapham, D.E., Ren, D., and  Xu, H. (2012) TPC Proteins are Sodium-selective Ion Channels in the Endosomes and Lysosomes.  Cell 151, 373-383, Oct. 12, 2012).  Evaluated by F1000. PDF

42. Zhang X., Li, X., and Xu, H. (2012) PIP2 Isoforms Determine Compartment-specific Ion Channel Activity . PNAS. 2012 (ePub June 25). PDF

43 Yu, T, Chung C, Shen, D., Xu, H., and Lieberman A.P (2012) Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann-Pick type C disease fibroblasts . Human Molecular Genetics. 2012 (ePub April 25). PDF

44. Shen, D., Wang, X.Li, X., Zhang, X., Yao, Z, Dibble, S., Dong, X.P, Yu, T, Lieberman A.P, and Xu, H. (2012) Lipid storage disorders block lysosomal trafficking by inhibiting TRP channel and calcium release. Nature Communications. 2012 Mar 13. 3 : 731 doi: 10.1038/ncomms1735  Evaluated by F1000. PDF

45. Jin J, Wu LJ, Jun J, Cheng X, Xu H, Andrews NC, Clapham DE. (2011) The channel kinase, TRPM7, is required for early embryonic development. PNAS (plus) ePub Dec 27, 2011. PDF

46 Shen, D., Wang, X., and Xu, H. (2011) Pairing Phosphoinositides with Calcium Ions in Endolysosomal Dynamics . BioEssays 2011 Jun;33(6):448-57. doi: 10.1002/bies.201000152. Epub 2011 Apr 28. PDF

47 Dong, XP.*, Shen, D.*, Wang, X.*, Dawson, T., Li, X., Zhang, Q., Cheng, X., Zhang, Y., Weisman, L., Delling, M., and Xu, H. (2010) PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome . Nature Communications, 1:38 doi: 10.1038/ncomms1037 2010 .  Evaluated by F1000. PDF

48. Samie, M.A, and Xu, H. (2010) Studying TRP Channels in Intracellualr Membranes. CRC press, Book chapter, TRP Channels–Methods in Signal Transduction Series. Chapter 19. PMID: 22593956 (Pubmed)

49. Cheng, X.*, Jin, J.*, Hu, L., Shen, D., Dong, X., Samie, M.A, Knoff, J., Eisinger, B., Liu, M., Huang, S.M., Caterina, M.J., Dempsey, P., Michael, L.E., Dlugosz, A., Andrews, N., Clapham DE, and Xu H  (2010) TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation. Cell 2010 10.1016/j.cell.2010.03.013. PDF Leading edge Preview Cell 141, April 16  Featured Publication Science Signaling ec 122 April 20  Evaluated by F1000.

50. Cheng, X., Shen, D., Samie, M.A., and Xu, H. (2010) Mucolipins: Intracellular TRPML1-3 Channels (Invited review). FEBS Letters 2010 Jan. 12 (Epub ahead of print). PDF

51. Mills, E, Dong, X., Wang, F., and Xu, H. (2010) Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders (Invited review). Future Medicinal Chemistry Jan. 2010, Vol. 2, No. 1, Pages 51-64. PDF

52 Dong, X., Wang, X., and Xu, H. (2009) TRP Channels of Intracellular Membranes (Invited review). Journal of Neurochemistry2010 Jan. 28 (Epub ahead of print). PDF

53. Dong, X.*, Wang,X.*, Shen,D.*,Chen, S., Liu, M., Wang, Y., Mills, E.,Cheng, X., Delling, M., and Xu, H. (2009) Activating mutations of the TRPML1 channel revealed by proline scanning mutagenesis.J. Biol. Chem. 10.1074/jbc.M109.037184. PDF

54. Dong, X, Cheng, X., Mills, E., Delling, M., Wang, F., Kurz, T. and Xu, H. (2008) The Type IV Mucolipidosis-Associated Protein TRPML1 is an Endo-lysosomal Iron Release Channel. Nature, 2008 (advance online publication) doi:10.1038/nature07311. PDF Evaluated by F1000.

55. Xu, H. *, Delling, M. *, Li, L*, Dong, X., and Clapham, DE (2007) Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint–waddler mice.Proceedings (USA), 2007, Nov 13;104(46):18321-6. Epub 2007 Nov 7. PDF Evaluated by F1000.


1.Xu, H., Delling, M., Jun, JC, and Clapham, DE (2006) Oregano, Thyme, and Clove-derived Flavors and Skin Sensitizers Activate Specific TRP Channels. Nature Neuroscience 2006 May; 9(5):628-635. Epub 2006 Apr 16.PDF

2. Xu, H.*, Blair, NT.*, and Clapham, DE. (2005) Camphor Activates and Strongly Desensitizes TRPV1 in a Vanilloid-independent Mechanism. The Journal of Neuroscience 2005; 25(39): 8924-37. PDF. The work was highlighted in The Journal of Neuroscience, 2005 Sep 28; 25(39), Nature, 2005 Oct 13; 437: 930-931, and Nature Reviews Neuroscience, 2005, 6: 826.

3. Zhuang, ZY., Xu, H., Clapham, DE., and Ji, RR.(2004) Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. The Journal of Neuroscience 2004; 24(38):8300-9. PDF

4. Ito, M.*, Xu, H.*, Guffanti, A., Wei, Y., Zvi, L., Clapham, DE., and Krulwich, TA.(2004) The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis and pH homeostasis of an alkaliphilic Bacillus. Proceedings of the National Academy of Sciences (USA) 2004; 101(29): 10566-71. Epub 2004 Jul 08. PDF

5. Moran, MM., Xu, H, and Clapham, DE. (2004) TRP ion channels in the nervous system. Current Opinion in Neurobiology 2004; 14(3): 362-9. PDF

6. Xu, H.*, Jin, J.*, DeFelice, LJ., Andrews, NC., and Clapham, DE. (2004) A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biology 2004 Mar;2(3):E50. Epub 2004 Mar 16. Synopsis can be found at PLoS Biol. 2004 Mar;2(3):E70. Epub 2004 Mar 16. 

7. Koishi, R.*, Xu, H.*, Ren D., Navarro B., Spiller BW., Shi Q., and Clapham, DE. (2004) A superfamily of voltage-gated sodium channels in bacteria. Journal of Biological Chemistry. 279(10):9532-8. Epub 2003 Dec 09. PDF

8. Xu, H.*, Ramsey, IS.*, Kotecha, SA.*, Moran, MM., Chong, JA., Curtis, R., DiStefano, PS., Silos-Santiago, I., Xie, Y., Lawson, D., Ge, P., Lilly, J., and Clapham, DE. (2002). TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature, 418, 181-186, published online 23 June 2002; doi:10.1038/nature00882. PDF Comments about this work and other groups’ related articles see “Breakthrough of The Year” by Science, Vol 298, Issue 5602, 2297-2303, 20 December 2002.

9. Ren, D.*, Navarro, B.*, Xu, H.*, Yue, L.*, Shi, Q., and Clapham, DE. (2001). A prokaryotic voltage-gated sodium channel. Science, Dec 14 2001: 2372-2375. Perspectives about this paper can be found in Science, 294: 2306-2308.PDF

10. Wang, R., Rojas, A., Wu, J., Piao, H., Adams C. Y., Xu, H., Shi, Y. and Jiang, C. (2005) Determinant role of membrane helices in gating of intracellular ligand-gated ion channels. Journal of Membrane Biology, 204, 1-10.

11. Wu, J., Xu, H., Shen, W., and Jiang, C. (2004) Expression and coexpression CO2-sensitive Kir channels in brainstem neurons of rats. Journal of Membrane Biology, 197(3):179-91.

12. Cui, N. *, Wu, J. *, Xu, H. *, Wang, R., Rojas, A., Piao, H., Mao, J., Abdulkadir, L., Li, L., and Jiang, C. (2003) A threonine residues (Thr71) plays a critical role in the gating Kir6.2 channel by intracellular ATP and pH. Journal of Membrane Biology, 192, 111-122.

13. Wu, J., Xu, H., Yang, Z., Wang, Y., Mao, J., and Jiang, C (2002). Protons activate homomeric Kir6.2 channels by selective suppression of the long and intermediate closures. Journal of Membrane Biology, 190, 105-116.

14. Wu, J., Cui, N., Piao, H., Wang, Y., Xu, H., Mao, J., and Jiang, C. (2002). Allosteric modulation of the mouse Kir6.2 channel by intracellular H+ and ATP. Journal of Physiology (London). 543, 495-505.

15. Xu, H., Wu, J., Cui, N., Abdulkadir, L., Wang, R., Mao, J., Giwa, LR., Chanchevalap, S., and Jiang, C. (2001). Distinct histidine residues control the acid-induced activation and inhibition of the cloned KATP channel. Journal of Biological Chemistry, 276, 38690-38696.

16. Jiang, C., Xu, H., Cui, N., and Wu, J. (2001). An alternative approach to the identification of respiratory central chemoreceptors in the brainstem. Respiratory Physiology, 2001 Dec;129(1-2):141-157.

17. Piao, H., Cui, N., Xu, H., Mao, J., Rojas, A., Wang, R., Abdulkadir, L., Li, L., Wu, J., and Jiang, C. (2001). Requirement of multiple protein domains and residues for gating KATP channels by intracellular pH. Journal of Biological Chemistry, 276, 36673-36680.

18. Cui, N., Giwa, LR., Xu, H., Abdulkadir, L., and Jiang, C. (2001). Modulation of the heteromeric Kir4.1-Kir5.1 channels by pCO2 at physiological levels, Journal of Cellular Physiology, 189, 229-236.

19. Jiang, C., Qu, Z., and Xu, H. (2001). Gating of inward rectifier K+ channels by proton-mediated interactions of internal protein domains. Trend in Cardiovascular Medicine, 12, 5-13.

20. Xu, H.*, Cui, N.*, Yang, Z., Wu, J., Giwa, LR., Abdulkadir, L., Sharma, P., and Jiang, C. (2001). Direct activation of KATP channels by intracellular acidosis. Journal of Biological Chemistry, 276, 12898-12902. * Co-first author.

21. Xu, H.*, Yang, Z.*, Cui, N., Valesky, WW., and Jiang, C. (2000). A single residue responsible for the difference of Kir4.1 channel from Kir1.1 in pH-sensitivity, rectification and single channel conductance. Journal of Physiology (London), 528.2, pp. 267-277.

22. Xu, H., Yang, Z., Cui, N., Giwa, LR., Abdulkadir, L., Patel, M., Sharma, P., Shan, G., Shen W., and Jiang C. (2000). Molecular determinants for the distinct pH sensitivity of Kir1.1 and Kir4.1. American Journal of Physiology (Cell) , 279: C1464-C1471.

23. Xu, H., Cui, N., Yang, Z., Qu, Z., and Jiang, C. (2000). Modulation of Kir4.1 and Kir5.1 by hypercapnia and intracellular acidosis. Journal of Physiology (London), 524, 725-735.

24. Yang, Z., Xu, H., Cui, N., Qu, Z., Chanchevalap, S., Shen, W., and Jiang, C. (2000). Biophysical and molecular mechanisms underlying the modulation of heteromeric Kir4.1-Kir5.1 channels by CO2 and pH. Journal of General Physiology 116: 33-46

25. Qu, Z., Yang, Z., Cui, N., Chanchevalap, S., Zhu, G., Liu, C., Xu, H., Shen, W., Wu, J., Li, Y., and Jiang, C. (2000) Kir gating by proton-mediated interactions of N- and C-terminal domains. Journal of Biological Chemistry, 275, 31573-31580.

26. Zhu, G., Liu, C., Chanchevalap, S., Xu, H., and Jiang, C. (2000) CO2 inhibits specific inward rectifier K+ channels by decreases in intra- and extracellular pH. Journal of Cellular Physiology, 183, 53-64.

27. Zhu, G., Zhang, Y., Xu, H. , and Jiang, C. (1998) Characterization of endogenous ionic currents of human embryonic kidney (HEK 293) cells, Journal of Neuroscience Methods. 81(1-2):73-83.

* Co-first author.

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