Publications

  1. The Kainate Receptor GluK2 Mediates Cold Sensing in Mice

Wei Cai, Wenwen Zhang, Qin Zheng, Chia Chun Hor, Tong Pan, Mahar Fatima, Xinzhong Dong, Bo Duan, X. Z. Shawn Xu

Nature Neuroscience, 11 March 2024

  1. Understanding Neural Mechanisms of Mechanical Itch

Jing Feng, Bo Duan

Journal of Allergy and Clinical Immunology, 5 July 2023

2. Molecular Determinants of Mechanical Itch Sensitization in Chronic Itch

Hankyu Lee, Robert D Graham, Diana Melikyan, Brennan Smith, Ehsan Mirzakhalili, Scott F Lempka, Bo Duan

Front. Mol. Neurosci., 16 June 2022

3. Lateral hypothalamic neuronal ensembles regulate pre-sleep nest-building behavior

Sotelo MI, Tyan J, Markunas C, Sulaman BA, Horwitz L, Lee H, Morrow JG, Rothschild G, Duan B, Eban-Rothschild A

Current Biology. 2022 Jan 11;S0960-9822(21)01740-1

4. Abnormal Somatosensory Behaviors Associated With a Gain-of-Function Mutation in TRPV3 Channels

Fatima M, Slade H, Horwitz L, Shi A, Liu J, McKinstry D, Villani T, Xu H, Duan B

Frontiers in Molecular Neuroscience. 2022 Jan 4;14:790435

5. Know Thy Enemy: Untangling the Mysteries of Neuropathic Pain

Fatima M, Hor CC, Duan B

Neuroscience Bulletin. 2021 Nov;37(11):1639-1641

6. Transient Receptor Potential Channels and Itch

Fatima M, Liu J, Duan B

Nonclassical Ion Channels in the Nervous System. 2021 Aug 5; Chapter 16

7. The Effect of Clinically Controllable Factors on Neural Activation During Dorsal Root Ganglion Stimulation. Neuromodulation: Technology at the Neural Interface.

Graham RD, Bruns TM, Duan B, Lempka SF

Neuromodulation: Technology at the Neural Interface, S.F. (2020)

8. A Cold-Sensing Receptor Encoded by a Glutamate Receptor Gene.

Gong J, Liu J, Ronan EA, He F, Cai W, Fatima M, Zhang W, Lee H, Li Z, Kim GH, Pipe KP, Duan B, Liu J, Xu XZS.

Cell. 2019 Sep 5;178(6):1375-1386.

9. Identification of a Spinal Circuit for Mechanical and Persistent Spontaneous Itch.

Pan H, Fatima M, Li A, Lee H, Cai W, Horwitz L, Hor CC, Zaher N, Cin M, Slade H, Huang T, Xu XZS, Duan B#.

Neuron. 2019 Sep 25;103(6):1135-1149.

10. How to Break a Fever: A Feedback Circuit for Body Temperature Control.

Duan B#, Xu XZS#.

Neuron. 2019 Jul 17;103(2):179-181. 

11. Dorsal root ganglion stimulation for chronic pain modulates Aβ-fiber activity but not C-fiber activity: A computational modeling study.

Graham RD, Bruns TM, Duan B, Lempka SF.

Clin Neurophysiol. 2019 Jun;130(6):941-951. 

12. Spinal somatostatin-positive interneurons transmit chemical itch.

Fatima M, Ren X, Pan H, Slade HFE, Asmar AJ, Xiong CM, Shi A, Xiong AE, Wang L, Duan B#.

Pain. 2019 May;160(5):1166-1174. 

13. Anatomical and functional dichotomy of ocular itch and pain.

Huang CC, Yang W, Guo C, Jiang H, Li F, Xiao M, Davidson S, Yu G, Duan B, Huang T, Huang AJW, Liu Q.

Nat Med. 2018 Aug;24(8):1268-1276. 

14. Spinal Circuits Transmitting Mechanical Pain and Itch.

Duan B#, Cheng L#, Ma Q#.

Neurosci Bull. 2018 Feb;34(1):186-193. 

15. Identification of spinal circuits involved in touch-evoked dynamic mechanical pain.

Cheng L*, Duan B*, Huang T, Zhang Y, Chen Y, Britz O, Garcia-Campmany L, Ren X, Vong L, Lowell BB, Goulding M, Wang Y, Ma Q.

Nat Neurosci. 2017 Jun;20(6):804-814. 

 Before 2016

  1. Lou S, Pan X, Huang T, Duan B, Yang FC, Yang J, Xiong M, Liu Y, Ma Q. Incoherent feed-forward regulatory loops control segregation of C-mechanoreceptors, nociceptors, and pruriceptors. J Neurosci. 35(13):5317-29. (2015)
  2. Bourane S, Duan B, Koch SC, Dalet A, Britz O, Garcia-Campmany L, Kim E, Cheng L, Ghosh A, Ma Q, et al. 2015. Gate control of mechanical itch by a subpopulation of spinal cord interneurons. Science 350: 550–554.doi:10.1126/science.aac8653
  3. Duan B*, Cheng L*, Bourane S, Britz O, Padilla C, Garcia-Campmany L, Krashes M, Knowlton W, Velasquez T, Ren X, Ross SE, Lowell BB, Wang Y, Goulding M, Ma Q. Identification of spinal circuits transmitting and gating mechanical pain. Cell. 159(6):1417-32. (2014) (*co-first author)
  4. Roberson DP, Gudes S, Sprague JM, Patoski HA, Robson VK, Blasl F, Duan B, Oh SB, Bean BP, Ma Q, Binshtok AM, Woolf CJ. Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons. Nat Neurosci.16(7):910-8. (2013)
  5. Zeng WZ, Liu DS, Duan B, Song XL, Wang X, Wei D, Jiang W, Zhu MX, Li Y, Xu TL. Molecular mechanism of constitutive endocytosis of Acid-sensing ion channel 1a and its protective function in acidosis-induced neuronal death. J Neurosci. 33(16):7066-78. (2013)
  6. Lou S*, Duan B*, Vong L, Lowell BB, Ma Q. Runx1 Controls Terminal Morphology and Mechanosensitivity of VGLUT3-expressing C-Mechanoreceptors. J Neurosci. 33(3):870-82. (2013) (*co-first author)
  7. Duan B*, Liu DS*, Huang Y, Zeng WZ, Wang X, Yu H, Zhu MX, Chen ZY, Xu TL. PI3-kinase/Akt pathway-regulated membrane insertion of acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity. J Neurosci. 32(18):6351-63. (2012) (*co-first author)
  8. Hu R, Duan B, Wang D, Yu Y, Li W, Luo H, Lu P, Lin J, Zhu G, Wan Q, Feng H. Role of acid-sensing ion channel 1a in the secondary damage of traumatic spinal cord injury. Ann Surg. 254(2):353-62. (2011)
  9. Duan B*, Wang YZ*, Yang T, Chu XP, Yu Y, Huang Y, Cao H, Hansen J, Simon RP, Zhu MX, Xiong ZG, Xu TL. Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci. 31(6):2101-12. (2011) (*co-first author)
  10. Liu Y, Abdel Samad O, Zhang L, Duan B, Tong Q, Lopes C, Ji RR, Lowell BB, Ma Q. VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. Neuron 68(3):543-56. (2010)
  11. Du W, Huang J, Yao H, Zhou K, Duan B, Wang Y. Inhibition of TRPC6 degradation suppresses ischemic brain damage in rats. J Clin Invest. 120(10):3480-92. (2010)
  12. Tong Z, Luo W, Wang Y, Yang F, Han Y, Li H, Luo H, Duan B, Xu T, Maoying Q, Tan H, Wang J, Zhao H, Liu F, Wan Y. Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain. PLoS One 5(4):e10234. (2009)
  13. Xu TL, Duan B. Calcium-permeable acid-sensing ion channel in nociceptive plasticity: a new target for pain control. Prog Neurobiol. 87(3):171-80. (2009) (Review)
  14. Duan B*, Wu LJ*, Yu YQ, Ding Y, Jing L, Xu L, Chen J, Xu TL. Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity. J Neurosci. 27(41):11139-48. (2007) (*co-first author)
  15. Wang W*, Duan B*, Xu H, Xu L, Xu TL. Calcium-permeable acid-sensing ion channel is a molecular target of neurotoxic metal ion lead. J Biol Chem. 281(5):2497-2505. (2006) (*co-first author)
  16. Gao J, Duan B, Wang DG, Deng XH, Zhang GY, Xu L, Xu TL. Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death. Neuron 48(4):635-46. (2005)
  17. Wu LJ, Duan B, Mei YD, Gao J, Chen JG, Zhuo M, Xu L, Wu M, Xu TL. Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. J Biol Chem. 279(42):43716-24. (2004)

News

Contact

Dr. Bo Duan
Associate Professor
Department of Molecular, Cellular and Developmental Biology
University of Michigan

Address:
1105 N University (Biological Science Building) 4264
Ann Arbor, MI 48109-1048

Tel: (734) 647-4359 (office)
(734) 615-7161 (lab)
Email: bduan@umich.edu