Publications

*Htet, Z.M., *Gillies, J.P., Baker, R.W., Leschziner, A.E., ^DeSantis, M.E., ^Reck-Peterson, S.L. (2020) Lis1 promotes the formation of activated cytoplasmic dynein complexes. Nature Cell Biology. 22, 518-525. *Authors contributed equally to this work, ^ Co-corresponding authors

Guo, L, Kim, H.J., Wang H., Monaghan, J., Freyermuth, F., Sung, J.C., O’Donovan, K., Fare, C.M., Diaz, Z., Singh, N., Zhang, Z.C., Coughlin, M., Sweeny, E.A., DeSantis, M.E., Jackrel, M.E., Rodell, C.B., Burdick, J.A., King, O.D., Gitler, A.D., Lagier-Tourenne, C., Pandey, U.B., Chook, Y.M., Taylor, J.P., Shorter, J. (2018) Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 173 (3): 677-692.

*DeSantis, M.E., *Cianfrocco, M.A., *Htet, Z.M., Tran, P.T., Reck-Peterson, S.L., Leschziner, A.E. (2017) Lis1 has two opposing modes of regulating cytoplasmic dynein. Cell. 170 (6): 1197-1208. *Authors contributed equally to this work

*Redwine, W.B., *DeSantis.M.E., Hollyer, I., Htet, Z.M., Tran, P.T., Swanson, S.K., Florens, L., Washburn, M.P., Reck-Peterson, S.L. (2017) The human cytoplasmic dynein interactome reveals novel activators of motility. eLife. 6:e28257. *Authors contributed equally to this work

Sweeny, E.A., Jackrel, M.E., Go, M.S.. Sochor, M.A., Razzo, B.M., DeSantis, M.E., Gupta, K., and Shorter. J. (2015). The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation. Mol. Cell. 57 (5): 836-849.

Jackrel M.E., DeSantis M.E., Martinez B., Castellano L.M., Stewart R.M., Caldwell K.A., Caldwell G.A., and Shorter J. (2014) Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events. Cell. 156: 170-182.

DeSantis, M.E., Sweeny, E.A., Snead, D.A., Leung, E.H., Go., M.S., Gupta, K., Wendler, P., and Shorter, J. (2013) Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation. Journal of Biological Chemistry. 289 (2): 848-867.

Coelho, M., Dereli, A., Haese, A., Kühn, S., Malinovska, L., DeSantis, M.E., Shorter, J., Alberti, S., Gross, T., and Tolić-Nørrelykke I.M. (2013) Fission yeast does not age under favorable conditions, but does so after stress. Current Biology. 23 (19): 1844-1852.

DeSantis, M.E. and Shorter, J. (2012) Hsp104 Drives “Protein-Only” Positive Selection of Sup35 Prion Strains Encoding Strong [PSI+]. Chemistry & Biology. 19 (11):1400-1410.

DeSantis, M.E., Leung, E.H., Sweeny, E.A., Jackrel, M., Cushman-Nick, M., Neuhaus-Follini, A., Vashist, S., Sochor, M.A, ,Knight, M.N, and Shorter, J. (2012) Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Nonamyloid Clients. Cell. 151 (4):778-793. (Previewed by Murray, A.N, and Kelly, J.W., Cell, 151:695-697).

Acchione, M., Lee, Y.C., DeSantis, M.E., Lipschultz, C.A., Wlodawer, A., Li, M., Shanmuganathan, A., Walter, R.L., Smith-Gill, S.J., and Barchi, J.J. (2012) Specific Fluorine Labeling of HyHel-10 Antibody Affects Antigen Binding and Dynamics. Biochemistry. 51 (30): 6017-6027.

Sweeny, E.A., DeSantis, M.E., and Shorter, J. (2011) Purification of Hsp104, a Protein Disaggregase. Journal of Visual Experiments (55), e3190, DOI: 10.3791/3190.

Mohan, S., Kourentzi, K., Schick, K.A., Uehara, C., Lipschultz, C.A., Acchione, M., DeSantis, M.E., Smith-Gill, S.J., and Willson, R.C. (2009) Association Energetics of Cross-Reactive and Specific Antibodies. Biochemistry. 48 (6):1390-1398.

Acchione, M., Lipschultz., C.A., DeSantis, M.E., Shanmuganathan, A., Li, M., Wlodawer, A., Tarasov, S., and Smith-Gill, S.J. (2009) Light Chain Somatic Mutations Change Thermodynamics of Binding and Water Coordination in the HyHel-10 Family of Antibodies. Molecular Immunology. 47 (2-3): 457-464.

Review Articles

*Cianfrocco, M.A., *DeSantis, M.E., Leschziner, A.E., and Reck-Peterson, S.L. (2015) Mechanism and Regulation of Cytoplasmic Dynein. Annu Rev Cell Dev Biol. 31:83-108. *Authors contributed equally to this work

DeSantis, M.E. and Shorter, J. (2012) The Elusive Middle Domain of Hsp104 and ClpB: Location and Function. Biochimica et Biophysica Acta. 1823 (1): 29-39.

DeSantis, M.E*. and Dersh, D*. (2010) Preventing Parkinson’s Pathology. Disease Models and Mechanisms. 3: 399-400. *co-corresponding authors