Our research focuses on applying state-of-the-art mass spectrometric techniques to the following areas: 1) identification and characterization of protein posttranslational modifications; 2) mapping macromolecular contact surfaces; 3) exploration of the gas-phase fragmentation behavior of various biomolecules following ion-electron interactions; and 4) probing covalent intermediates in the catalysis of non-ribosomal peptide synthetases and polyketide synthases. A major goal is to excel in both analytical technique development and biologically relevant problem solving.

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