Selected Publications – Hume Lab

Selected Publications

Li P, Hu M, Wang C, Feng X, Shao Z Yang Y Sahoo N, Gu M, Yang Y, Xiao S, Sah R, Cover TL, Chou J, Geha R, Benavides F, Hume RI and Xu H (2020) “LRRC8 family proteins within Lysosomes Regulate Cellular Osmoregulation and Enhance Cell Survival to Multiple Physiological Stresses” Proceedings of the National Academy of Sciences 117 (46), 29155-29165 [Link to the Paper]

Hsu I, Linsley JW, Zhang,X, Varineau JE, Berkhoudt DA, Reid LE, Lum MC Orzel AM, Leflein A, Xu H, Collins CA Hume RI, Levitan ES and Kuwada JY (2020) “Stac Protein Regulates Release of Neuropeptides”  Proceedings of the National Academy of Sciences 117 (47), 29914-29924 [Link to the Paper]

Hsu I-U, Linsley JW, Reid LE, Hume RI, Leflein A and Kuwada JY (2020) Dstac Regulates Excitation-Contraction Coupling in Drosophila Body Wall Muscles. Front. Physiol. 11:573723. [Link to the Paper]

Hao Y, Waller TJ, Nye DM, Li J, Zhang Y, Hume RI, Rolls MM, Collins CA (2019) Degeneration of Injured Axons and Dendrites Requires Restraint of a Protective JNK Signaling Pathway by the Transmembrane Protein Raw. J Neurosci. 23;39(43):8457-8470. 

Li, J, Zhang YV, Asghari Adib, E, Stanchev DT, Xiong X, Klinedinst S, Soppina P,  Jahn, TR, Hume RI, Rasse TM, Collins, CA (2017) Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104  eLife  [Link to the Paper]

Ramamurthy P, White JB, Park JY, Hume RI, Ebisu F, Mendez F, Takayama S and Barald KF  (2017) Concomitant differentiation of a population of mouse embryonic stem cells into neuron-like cells and Schwann cell-like cells in a slow-flow microfluidic device. Developmental Dynamics 246:7–27 [Link to the Paper]

Punthambaker S, Hume RI, (2014) Potent and long-lasting inhibition of human P2X2 receptors by copper” 77:167-76 PMID: 24067922 [Link to the Paper]

Punthambaker S, Blum JA, Hume RI. (2012). High potency zinc modulation of human P2X2 receptors and low potency zinc modulation of rat P2X2 receptors share a common molecular mechanism. J Biol Chem. 287: 22099-22111.  [Link to the Paper]

Mouslim, C, Aittaleb, M, Hume, RI and Akaaboune, M. (2012). A role for the CaM Kinase II related anchoring protein (αkap) in maintaining the stability of nicotinic Acetylcholine Receptors. Journal of Neuroscience, 32:5177-85. [Link to the Paper]

Low SE, Amburgey K, Horstick E, Linsley J, Sprague SM, Cui WW, Zhou W, Hirata H, Saint-Amant L, Hume RI, and Kuwada JY . (2011). TRPM7 is required within zebrafish sensory neurons for the activation of touch-evoked escape behaviors. Journal of Neuroscience, 31:11633-11644.  [Link to the Paper]

Low SE, Ryan, J, Sprague S, Hirata H, Cui W, Zhou W, Hume RI, Kuwada JY, and Saint-Amant L. (2010). Touché is required for touch evoked generator potentials within vertebrate sensory neurons. Journal of Neuroscience, 30:9359-9367.  [Link to Paper]

Low SE, Zhou W, Choong X, Saint-Amant L, Sprague SM, Hirata H, Cui WW, Hume RI, Kuwada J.. (2010). Na(V)1.6a is required for normal activation of motor circuits normally excited by tactile stimulation. Developmental Neurobiology, 70:508-22.  [Link to Paper]

Low, SE, Kuwada JY and Hume RI. (2008). Amino acid variations resulting in functional and nonfunctional zebrafish P2X1 and P2X5.1 Receptors. Purinergic Signaling, 4:383-392.  [Link to Paper]

Tittle, RK and Hume, RI. (2008). Opposite effects of zinc on human and rat P2X2 receptors. Journal of Neuroscience, 28:11,131–140. [Link to Paper]

Friday, SC and Hume RI. (2008). Contribution of extracellular negatively charged residues to ATP action and zinc modulation of rat P2X(2) receptors. Journal of Neurochemistry, 105:1264-75.  [Link to Paper]

Saint-Amant L, Sprague SM, Hirata H, Li Q, Cui WW, Zhou W, Poudou O, Hume RI, and Kuwada, JY. (2008). The Zebrafish ennui Behavioral Mutation Disrupts Acetylcholine Receptor Localization and Motor Axon Stability. Developmental Neurobiology, 68:45-61.  [Link to Paper]

Moffatt, L and Hume, RI . (2007). Responses of rat P2X2 receptors to ultrashort pulses of ATP provide insights into ATP binding and channel gating. Journal of General Physiology, 130: 183-201. [Link to Paper]

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