Welcome to the Pecoraro Lab! Our research at the University of Michigan focuses on inorganic and bioinorganic chemistry. We are interested in the development and design of Metallacrowns and Metallopeptides with novel and innovative applications.
Our latest Metallopeptide paper on our efforts to rationally design copper proteins with a CuHis2CysGlu binding sites with either green or blue copper chromophores using mutation strategies that have proven successful in native cupredoxins.
Read in JACS!
“[Ga3+8Sm3+2, Ga3+8Tb3+2] Metallacrowns are Highly Promising Ratiometric Luminescent Molecular Nanothermometers Operating at Physiologically Relevant Temperatures”
Our latest Metallopeptide paper is a review on protein design efforts to create de novo metalloproteins within alpha‐helical scaffolds. Read in Angewandte Chemie International Ed!
Peculiarities of crystal structures and photophysical properties of GaIII/LnIII metallacrowns with a non-planar [12-MC-4] core
Our latest Metallacrown paper on X-ray single crystal analysis revealing two types of structures depending on whether the nitrate counterion in the metallacrown coordinates or not to the Ln(III) center. Read it in Inorganic Chemistry Frontiers!
Our latest Metallopeptide paper showing how it is possible to form pure heterotrimeric three-stranded coiled coils by combining three distinct characteristics: (1) a cysteine sulfur layer for metal coordination, (2) a thiophilic, trigonal pyramidal metalloid (Pb(ii)) that binds to these sulfurs and (3) an adjacent layer of reduced steric bulk generating a cavity where water can hydrogen bond to the cysteine sulfur atoms. Read it in Nature Chemistry!