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Welcome to the Pecoraro Lab! Our research at the University of Michigan focuses on inorganic and bioinorganic chemistry. We are interested in the development and design of Metallacrowns and Metallopeptides with novel and innovative applications.

 

Group News

 

Peculiarities of crystal structures and photophysical properties of GaIII/LnIII metallacrowns with a non-planar [12-MC-4] core

Our latest Metallacrown paper on X-ray single crystal analysis revealing two types of structures depending on whether the nitrate counterion in the metallacrown coordinates or not to the Ln(III) center. Read it in Inorganic Chemistry Frontiers!

Heteromeric Three-Stranded Coiled Coils Designed Using a Pb(II)(Cys)3 Template Mediated Strategy

Our latest Metallopeptide paper showing how it is possible to form pure heterotrimeric three-stranded coiled coils by combining three distinct characteristics: (1) a cysteine sulfur layer for metal coordination, (2) a thiophilic, trigonal pyramidal metalloid (Pb(ii)) that binds to these sulfurs and (3) an adjacent layer of reduced steric bulk generating a cavity where water can hydrogen bond to the cysteine sulfur atoms. Read it in Nature Chemistry!

Rational De Novo Design of a Cu-Metalloenzymes for Superoxide Dismutation

Our latest paper on Superoxide dismutases (SODs) shows that rationally designed proteins with well-defined three-dimensional structures offer new opportunities for obtaining functional SOD mimics. Find it in Chemistry A European Journal!

Prof. Pecoraro elected as President of SBIC 2020-2022
Congratulations to Prof. Pecoraro  on becoming the newest President of the Society of Biological Inorganic Chemistry (SBIC)! He will hold the position from October 2020 to September 2022.

Iodinated Metallacrowns: Toward Combined Bimodal Near-Infrared and X-ray Contrast Imaging Agents

Here is our latest paper on Metallacrown functionalization for the development of biomodal imaging agents. We show that our luminescent 12-MC-4 dimer structures can be synthetically modified to have 4, 8, or 12 iodines, resulting on a complex capable of X-ray attenuation and luminescence. Find it in Chemistry A European Journal!

 

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