Publications

See Wang’s full publication list at PubMed.

Zhang X,  Wang Y. (2020) Non-redundant roles of GRASP55 and GRASP65 in the Golgi apparatus and beyond. Trends Biochem Sci . 2020 Sep 4;S0968-0004(20)30198-5. PubMed

Ireland SC, Huang H, Zhang J, Li J, Wang Y. (2020) Hydrogen peroxide induces Arl1 degradation and impairs Golgi-mediated trafficking. Mol Biol Cell. 2020 Aug 1;31(17):1931-1942. doi: 10.1091/mbc.E20-01-0063. PubMed

Ireland SC, Ramnarayanan S, Fu M, Zhang X, Zhang J, Li J, Emebo D, Wang Y. (2020) Cytosolic Ca2+ modulates Golgi structure through PKCα-mediated GRASP55 phosphorylation. iScience. 2020 Feb 28;23(3):100952. doi: 10.1016/j.isci.2020.100952. PubMed

Prydz K, Lupashin V, Wang Y, Saraste J. (2020) Editorial: Golgi Dynamics in Physiological and Pathological Conditions. Front Cell Dev Biol. 2020 Jan 29;8:7. doi: 10.3389/fcell.2020.00007. eCollection 2020. PubMed

Eisenberg-Lerner A, Benyair R, Hizkiahou N, Nudel N, Maor R, Kramer MP, Shmueli MD, Zigdon I, Cherniavsky Lev M, Ulman A, Sagiv JY, Dayan M, Dassa B, Rosenwald M, Shachar I, Li J, Wang Y, Dezorella N, Khan S, Porat Z, Shimoni E, Avinoam O, Merbl Y. (2020) Golgi organization is regulated by proteasomal degradation. Nat Commun. 2020 Jan 21;11(1):409. doi: 10.1038/s41467-019-14038-9. PubMed

Sahoo BR, Bekier M, Liu Z, Kocman V, Stoddard A, Anantharamaiah G; Nowick J; Fierke CA, Wang Y, Ramamoorthy A. (2019) Structural Interaction of Apolipoprotein A-I Mimetic Peptide with Amyloid-β Generates Toxic Hetero-oligomers. J Mol Biol. 2019 Dec 19. pii: S0022-2836(19)30705-3. PubMed

Zhang X, Brachner A, Kukolj E, Slade D, Wang Y. (2019) SIRT2 deacetylates GRASP55 to facilitate post-mitotic Golgi assembly. J Cell Sci. 2019 Nov 1;132(21). pii: jcs232389. doi: 10.1242/jcs.232389. PubMed

Ahat E, Li J, Wang Y. (2019) New insights into the Golgi stacking proteins. Front Cell Dev Biol. 2019 Jul 16;7:131. doi: 10.3389/fcell.2019.00131. PubMed

Zhang X, Wang L, Ireland S, Ahat E, Li J, Bekier M, Zhang Z, Wang Y. (2019) GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion. Autophagy. 2019 Mar 20. doi: 10.1080/15548627.2019.1596480.  PubMed

Li J, Ahat E, Wang Y. (2019) Golgi structure and function in health, stress and diseases.Results Probl Cell Differ. 2019;67:441-485. doi: 10.1007/978-3-030-23173-6_19. In The Golgi Apparatus and Centriole. Springer Nature.  PubMed

Ahat E, Xiang Y, Zhang X, Wang Y. (2019) GRASP depletion-mediated Golgi destruction decreases cell adhesion and migration via the reduction of α5β1 integrin. Mol Biol Cell. 2019 Jan 16:mbcE18070462. doi: 10.1091/mbc.E18-07-0462. PubMed

Li J, Tang D, Ireland SC, Wang Y. (2019) DjA1 maintains Golgi integrity via interaction with GRASP65. Mol Biol Cell. 2019 Feb 15;30(4):478-490. doi: 10.1091/mbc.E18-10-0613PubMed

Sahoo BR, Genjo T, Bekier M, Cox SJ, Stoddard AK, Ivanova M, Yasuhara K, Fierke CA, Wang Y, Ramamoorthy A. (2018) Alzheimer’s amyloid-beta intermediates generated using polymer-nanodiscs. Chem Commun (Camb). 2018 Nov 13;54(91):12883-12886. doi: 10.1039/c8cc07921h.

Zhang X,  Wang Y. (2018) GRASP55 facilitates autophagosome maturation under glucose deprivation. Molecular & Cellular Oncology. https://doi.org/10.1080/23723556.2018.1494948.

Zhang X,  Wang Y. (2018) The Golgi stacking protein GRASP55 serves as an energy sensor to promote autophagosome maturation under glucose starvation. Autophagy. 2018 Jul 29:1-3. doi: 10.1080/15548627.2018.1491214. PubMed

Zhang X, Wang L, Lak B, Li J, Jokitalo E, Wang Y. (2018) GRASP55 senses glucose deprivation through O-GlcNAcylation to promote autophagosome-lysosome fusion. Dev Cell. 2018 Apr 23;45(2):245-261.e6. doi: 10.1016/j.devcel.2018.03.023. PubMed

Huang, S and  Wang Y. (2017) Golgi structure formation, function, and post-translational modifications in mammalian cells. F1000Research 2017, (F1000 Faculty Rev):2050 (doi: 10.12688/f1000research.11900.1). Weblink

Bekier M, L. Wang, J. Li, H. Huang, D. Tang, X. Zhang and Y. Wang. (2017) Knockout of the Golgi stacking proteins GRASP55 and GRASP65 impairs Golgi structure and function.  Mol Biol Cell. 2017 Aug 16. pii: mbc.E17-02-0112. doi: 10.1091/mbc.E17-02-0112. [Epub ahead of print]. PubMed

Wang Y. Golgi cisternal stacking is required for accurate glycosylation. Mizutani Foundation for Glycoscience 25th anniversary research collection, 2017, page 26-27.

Sahoo X.,  Gu M., Zhang X., Raval N., Yang J., Bekier M., Calvo R, Patnaik S., Wang W., King G., Samie M., Gao Q, Sahoo S., Sundaresan S., Keeley T., Wang Y., Margin J., Ferrer M., Samuelson L., Merchant J., Xu H. (2017) Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca2+ Efflux Channel in the Tubulovesicle. Developmental Cell. May 8, 2017. DOI: http://dx.doi.org/10.1016/j.devcel.2017.04.003. PubMed

Tan, X., P. Banerjee, H.F. Guo, S. Ireland, D. Pankova, Y.H. Ahn, H. Nikolaidis, X. Liu, Y. Zhao, Y. Xue, A.R. Burns, J. Roybal, D.L. Gibbons, T. Zal, C.J. Creighton, D. Ungar, Y. Wang, and J.M. Kurie. (2016). Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through PAQR11. J Clin Invest. 2016 Nov 21. pii: 88736. doi: 10.1172/JCI88736. PubMed

Huang, S., D. Tang and Y. Wang. (2016). Monoubiquitination of syntaxin 5 regulates Golgi membrane dynamics during the cell cycle. Developmental Cell. 2016 Jul 11;38(1):73-85. doi: 10.1016/j.devcel.2016.06.001. PubMed

Zhang, X. and Y. Wang. (2016). Glycosylation quality control by the Golgi structure. Journal of Molecular Biology. 2016 Mar 5. pii: S0022-2836(16)00160-1. doi: 10.1016/j.jmb.2016.02.030. PubMed

Zhang, X. and Y. Wang. (2016). GRASPs in Golgi Structure and Function. Front Cell Dev Biol. 2016 Jan 6;3:84. doi: 10.3389/fcell.2015.00084.  PubMed

Tang, D., X. Zhang, S. Huang, H. Yuan, J Li and Y. Wang. (2016). Mena-GRASP65 interaction couples actin polymerization to Golgi ribbon linking. Mol Biol Cell. 2016 Jan 1;27(1):137-52. doi: 10.1091/mbc.E15-09-0650. PubMed

Joshi. G., M. Bekier and Y. Wang. (2015). Golgi fragmentation in
 Alzheimer’s disease. Front Neurosci. 2015 Sep 24;9:340. doi: 10.3389/fnins.2015.00340. PubMed

Tang. D. and Y. Wang. (2015). Golgi isolation. In Subcellular Fractionation, Edited by Paul Pryor and Judy Cuddihy. Cold Spring Harbor Laboratory Press (CSHLP) 2015 Jun 1;2015(6):pdb.prot075911. doi: 10.1101/pdb.prot075911. PubMed

Zhang, X. and Y. Wang. (2015).   Cell cycle regulation of VCIP135 deubiquitinase activity and function in p97/p47-mediated Golgi reassembly. Mol Biol Cell. 2015 Jun 15;26(12):2242-51. doi: 10.1091/mbc.E15-01-0041. [Epub ahead of print] PubMed

Zhang X., L. Gui, X. Zhang, S.L. Bulfer, V. Sanghez, D. Wong, J. Lee, P. Shih, C.C. Weihl, H.J. Lin, P.W. Sternberg, M. Iacovino, M.R. Arkin, Y. Wang and T.F. Chou. (2015). Altered cofactor regulation with disease associated p97/VCP mutations. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1705-14. Epub 2015 Mar 16. PubMed

Joshi G. and Y. Wang. (2015).  Golgi defects enhance APP amyloidogenic processing in Alzheimer’s disease. BioEssays,  2015 Mar;37(3):240-7. doi: 10.1002/bies.201400116. Epub 2014 Dec 28. PubMed * Highlighted article of the journal: Genevieve Evin. 2015. How accelerated Golgi trafficking may drive Alzheimer’s disease (comment on DOI 10.1002/bies.201400116). Bioessays, Mar;37(3):232-3. doi: 10.1002/bies.201400219. Epub 2015 Jan 19.

Joshi G., Y. Chi, Z. Huang and Y. Wang. (2014).  Aβ-induced Golgi fragmentation in Alzheimer’s disease enhances Aβ production. PNAS Plus,  111: E1230-9. PubMed * Highlighted by newsagents worldwide.

Zhang, X., H. Zhang and Y. Wang. (2014).   Phosphorylation regulates VCIP135 function in Golgi membrane fusion during the cell cycle.  J Cell Science, 127:172-181. PubMed * Highlighted in “In This Issue”, Journal of Cell Science.

Tang. D. and Y. Wang. (2013).  Cell cycle regulation of Golgi membrane dynamics. Trends in Cell Biology, 23(6): 296-304. PubMed

Xiang, Y., X. Zhang, D. Nix, T. Katoh, K Aoki, M. Tiemeyer and Y. Wang. (2013).  Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65. Nature Communications, 4:1659. doi: 10.1038/ncomms2669. PubMed * Highlighted by Faculty 1000.

Tang. D. and Y. Wang. (2013).  Golgi: Methods for Preparation (version 3.0). In Encyclopedia of Life Sciences, DOI: 10.1002/9780470015902.a0002590.pub3. John Wiley & Sons, Ltd. PubMed

Sangwung P., T.M. Greco, Y. Wang, H. Ischiropoulos, W.C. Sessa and Y. Iwakiri Y. (2012). Proteomic Identification of S-nitrosylated Golgi Proteins: New Insights into Endothelial Cell Regulation by eNOS-derived NO. PLoS ONE, 7(2):e31564. PubMed

Tang. D., H. Yuan, O. Vielemeyer, F. Perez, Y. Wang. (2012). Sequential phosphorylation of GRASP65 during mitotic Golgi disassembly. Biology Open, 1 (12): 1204-1214. PubMed

Chen X., P. Andrews and Y. Wang. (2012). Quantitative proteomics analysis of cell cycle regulated Golgi disassembly and reassembly. Methods Molecular Biology, 909:125-40. PubMed

Cui, F. ad Y. Wang. (2012). HACE1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1). Atlas Genet Cytogenet Oncol Haematol, PubMed

Tang D., Y. Xang, S. De Renzis, J. Rink, G. Zheng, M. Zerial and Y. Wang. (2011). The ubiquitin ligase HACE1 regulates Golgi membrane dynamics during the cell cycle. Nature Communications, 2:501. doi: 10.1038/ncomms1509. PubMed

Xiang, Y. and Y. Wang. (2011). New Components of the Golgi Matrix. Cell Tissue Res., 344(4):365-79. PubMed

Y. Wang and J. Seemann. (2011). Golgi Biogenesis. In “The Golgi”. Cold Spring Harb Perspect Biol, Editors: Graham Warren and James Rothman. Page 255-266. PubMed

Xiang, Y. and Y. Wang. (2010). GRASP55 and GRASP65 play complementary and essential roles in Golgi cisternal stacking. J Cell Biol, 188 (2): 237–251. PubMed

Chen, X., E. Simon, Y. Xiang, M. Kachman, P. Andrews and Y. Wang. (2010).  Quantitative proteomics analysis of cell cycle regulated Golgi disassembly and reassembly. J Biol Chem, 285:7197-7207. PubMed

Tang, D., Y. Xiang and Y. Wang. (2010).  Reconstitution of the cell cycle regulated Golgi disassembly and reassembly in a cell free system. Nature Protocols, 5 (4): 758-72. PubMed

Tang, D., H. Yuan and Y. Wang. (2010). The role of GRASP65 in Golgi cisternal stacking and cell cycle progression. Traffic, 11 (6): 827-842. PubMed

Yin, K., Z. Deng, M. Hamblin, Y. Xiang, H. Huang, J. Zhang, X. Jiang, Y. Wang, and Y. E. Chen. (2010). PPARδ regulation of miR-15a in ischemia-induced cerebral vascular endothelial injury. J. Neuroscience, 30 (18): 6398-408. PubMed

Vielemeyer, O, H. Yuan, S. Moutel, R. Saint-Fort, D. Tang, C. Nizak, B. Goud, Y. Wang*, and F. Perez*. (2009).  Direct Selection of Monoclonal Phosphospecific Antibodies without Prior Phosphoamino Acid Mapping. J Biol Chem, 284: 20791-20795. (* Co-corresponding authors). PubMed

Tang, D., K. Mar, G. Warren and Y. Wang. (2008). Molecular mechanism of mitotic Golgi disassembly and reassembly revealed by a defined reconstitution assay. J Biol Chem, 283: 6085-94. PubMed

Wang, Y.. (2008). Golgi: Methods for Preparation. In Encyclopedia of Life Sciences, John Wiley & Sons, Ltd. PubMed

Wang, Y.. (2008). Golgi apparatus inheritance. In The Golgi apparatus. State of the art 110 years after Camillo Golgi’s discovery. , Edited by A. Mironov, M. Pavelka and A. Luini. Springer-Verlag Gmbh, Wien-New York. Chapter 4.3. Page 580-607.

Wang, Y., J. Wei, B. Bisel, D. Tang and J. Seemann. (2008). Golgi cisternal unstacking stimulates COPI vesicle budding and protein transport. PLoS ONE, 3:e1647. PubMed * Highlighted by Faculty 1000.

Bisel, B., Y. Wang, JH. Wei, Y. Xiang, D. Tang, M. Miron-Mendoza, S. Yoshimura, N. Nakamura and J. Seemann. (2008). ERK regulates Golgi and centrosome orientation towards the leading edge through GRASP65. J Cell Biol, 182: 837-43. PubMed

Xiang, Y., J. Seemann, B. Bisel, S. Punthambacker and Y. Wang. (2007). Active ARF1 is required for mitotic Golgi fragmentation. J Biol Chem, 282: 21829-37. PubMed

Wang, Y., T. Taguchi and G. Warren. (2006). Purification of rat liver Golgi stacks . In Cell Biology: A Laboratory Handbook 3rd Edition, 33-39. Edited by Julio Celis. Elservier Science (USA), San Diego. Page 33-39.

Wang, Y.*, A. Satoh, and G. Warren. (2005). Mapping the functional domains of the Golgi stacking factor GRASP65. J Biol Chem, 280: 4921-8. (*Corresponding author). PubMed

Wang, Y., A. Satoh, G. Warren, and H.H. Meyer. (2004). VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments. J Cell Biol, 164: 973-8.  PubMed * Highlighted in “In This Issue”, J. Cell Biol, 164 (7): 951, 2004.

Wang, Y., J. Seemann, M. Pypaert, J. Shorter, and G. Warren . (2003). A direct role for GRASP65 as a mitotically regulated Golgi stacking factor. EMBO J, 22:3279-90. PubMed * Highlighted in Nature “News and Views In Brief”, Nature, 424: 265, 2003.

Satoh, A., Y. Wang, J. Malsam, M.B. Beard, and G. Warren. (2003). Golgin-84 is a rab1 binding partner involved in Golgi structure. Traffic, 4: 153-61. PubMed

Meyer, H.H.*, Y. Wang*, and G. Warren. (2002). Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4. EMBO J, 21: 5645-52. (*Both authors contributed equally). PubMed

Wang, Y., C Thiele and WB Huttner. (2000). Cholesterol is required for the formation of regulated and constitutive secretory vesicles from the trans-Golgi network. Traffic, 1 (12): 952-962. PubMed