2022 | 2021 | 2020 | 2019 | 2018 | 2017| 2016 | 2015 | 2014 | 2013 | 2012
2011-2001 Publications | 2000-1991 Publications | 1990-1984 Publications
In most cases, a blue title links to a PDF of the article.
2022 Publications
Wu K, Minshull TC, Radford SE, Calabrese AN, Bardwell JCA. Trigger factor both holds and folds its client proteins. Nat Commun. 2022 Jul 15;13(1):4126. doi: 10.1038/s41467-022-31767-6. PubMed
Choudhary V, Wu K, Zhang Z, Dulchavsky M, Barkman T, Bardwell JCA, Stull F. The Enzyme Pseudooxynicotine Amine Oxidase From Pseudomonas Putida S16 Is Not An Oxidase, Bua A Dehydrogenase. Journal of Biological Chemistry. 2022 Jul 11. doi: 10.1016/j.jbc.2022.102251 PubMed
Sahoo BR, Bardwell JCA. SERF, A Family Of Tiny Highly Conserved, Highly Charged Proteins With Enigmatic Functions. The FEBS Journal. 2022 Jun 13doi: 10.0000/febs,16555. PubMed
Rishav Mitra, Kevin Wu, Changhan Lee, and James C.A. Bardwell ATP-Independent Chaperones. Annual Reviews of Biophysics 2022 Feb 15. PubMed
2021 Publications
Beaufay F, Amemiya HM, Guan J, Basalla J, Meinen BA, Chen Z, Mitra R, Bardwell JCA, Biteen JS, Vecchiarelli AG, Freddolino PL, Jakob U. Polyphosphate drives bacterial heterochromatin formation. Science Advances. 2021 Dec 24;7(52):eabk0233. doi: 10.1126/sciadv.abk0233. Epub 2021 Dec 22. PMID: 34936433. PubMed
Mitra R, Gadkari VV, Meinen BA, van Mierlo CPM, Ruotolo BT, Bardwell JCA. Mechanism of the small ATP-independent chaperone Spy is substrate specific. Nat Commun. 2021 Feb 8;12(1):851. doi: 10.1038/s41467-021-21120-8. PubMed
Dulchavsky M, Clark CT, Bardwell JCA, Stull F. A cytochrome c is the natural electron acceptor for nicotine oxidoreductase. Nature Chemical Biology. 2021 January 11. https://doi.org/10.1038/s41589-020-00712-3 PubMed
2020 Publications
He W, Zhang J, Sachsenhauser V, Wang L, Bardwell JCA, Quan S. Increased surface charge in the protein chaperone Spy enhances its anti-aggregation activity. J Biol Chem. 2020 Aug 17:jbc.RA119.012300. doi: 10.1074/jbc.RA119.012300. Online ahead of print. PubMed
Lee C, Betschinger P, Wu K, Zyla DS, Glockshuber R, Bardwell JCA. A metabolite binding protein moonlights as a bile-responsive chaperone. EMBO J. 2020 Sep 3;e104231. doi: 10.15252/embj.2019104231. Online ahead of print. PubMed
Sachsenhauser V, Deng X, Kim HH, Jankovic M, Bardwell JCA. Yeast Tripartite Biosensors Sensitive to Protein Stability and Aggregation Propensity. ACS Chem Biol. 2020 Apr 17;15(4):1078-1088. doi:10.1021/acschembio.0c00083. Epub 2020 Mar 10. PubMed
2019 Publications
Rocchio S, Duman R, Omari KE, Mykhalylyk V, Orr C, Yan Z, Salmon L, Wagner A, Bardwell JCA, Horowitz S. Identifying dynamic ,partially occupied residues using anomalous scattering. Acta Crys 2019. D75, 1084-1095.
Meinen BA, Gadkari VV, Stull F, Ruotolo BT, Bardwell JCA. SERF engages in a fuzzy complex that accelerates primary nucleation of amyloid proteins. Proc Natl Acad Sci USA 2019 Oct 28. pii: 201913316. doi: 10.1073/pnas.1913316116. PubMed [FACULTY OPINIONS]
Wu K, Stull F, Lee C, Bardwell JCA. Protein folding while chaperone bound is dependent on weak interactions. Nat Commun 2019 Oct 23;10(1):4833. doi: 10.1038/s41467-019-12774-6. PubMed
Yan Z, Hussain S, Xu W, Bernstein HD, Bardwell JCA. Chaperone OsmY facilitates the biogenesis of a major family of autotransporters. Mol Microbiol 2019 Aug 1 doi: 10.1111/mmi.14358. PubMed
Teixeira F, Tse E, Castro H, Makepeace KAT, Meinen BA, Borchers CH, Poole LB, Bardwell JC, Tomás AM, Southworth DR, Jakob U. Chaperone activation and client binding of a 2-cysteine peroxiredoxin. Nat Commun. 2019 Feb 8;10(1):659. doi: 10.1038/s41467-019-08565-8. PubMed
Return to top2018 Publications
Stull F, Hipp H, Stockbridge RB, Bardwell JCA. In vivo chloride concentrations surge to proteotoxic levels during acid stress. Nature Chemical Biology 2018 Oct; 14, 1051-1058. PubMed This paper was the subject of a News and Views [PDF] citation in Nature Chemical Biology by Colin Kleanthous. [FACULTY OPINIONS]
Cristie-David AS, Koldewey P, Meinen BA, Bardwell JCA, Marsh ENG. Elaborating a coiled coil-assembled octahedral protein cage with additional protein domains. Protein Sci. 2018 Aug 16. doi: 10.1002/pro.3497. PubMed
Lee C, Kim H, Bardwell JCA. Electrostatic interactions are important for chaperone-client interaction in vivo. Microbiology. 2018 Jul;164(7):992-997. doi: 10.1099/mic.0.000676. PubMed
Salmon L, Ahlstrom LS, Bardwell JCA, Horowitz S. Selecting Conformational Ensembles Using Residual Electron and Anomalous Density (READ). Methods Mol Biol . 2018;1764:491-504. doi: 10.1007/978-1-4939-7759-8_31 PubMed
Stull F, Betton J, Bardwell J. 2018. Periplasmic Chaperones and Prolyl Isomerases, EcoSal Plus 2018; doi:10.1128/ecosalplus.ESP-0005-2018. PubMed
Stull F, Bardwell JC. Folding against the wind. Nature Chemical Biology 2018 Apr;14(4):329-330. doi: 10.1038/s41589-018-0016-5. PubMed
Sachsenhauser V, Bardwell JC. Directed evolution to improve protein folding in vivo. Curr Opin Struct Biol. 2018 Feb;48:117-123. doi: 10.1016/j.sbi.2017.12.003. PubMed
2017 Publications
Salmon L, Stull F, Sayle S, Cato C, Akgül Ş, Foit L, Ahlstrom LS, Eisenmesser EZ, Al-Hashimi HM, Bardwell JCA, Horowitz S. The Mechanism of HdeA Unfolding and Chaperone Activation. J Mol Biol. 2018 Jan 5;430(1):33-40. doi: 10.1016/j.jmb.2017.11.002. Epub 2017 Nov 11. PubMed
Badieyan S, Sciore A, Eschweiler J, Koldewey P, Cristie-David AS, Ruotolo BT, Bardwell JCA, Su M, Marsh N. Symmetry-directed Self-assembly of a Tetrahedral Protein Cage Mediated by De Novo-designed Coiled Coils. Chembiochem. 2017 Aug 1. doi: 10.1002/cbic.201700406. [Epub ahead of print] PubMed
Horowitz S, Koldewey P, Stull F, Bardwell JC. Folding while bound to chaperones. Curr Opin Struct Biol. 2018, 48:1–5, online 2017 Jul 19;
doi: 10.1016/j.sbi.2017.06.009. PubMed
Koldewey P, Horowitz S, Bardwell JCA. Chaperone-client interactions: Non-specificity engenders multifunctionality. J Biol Chem. 2017 Jul 21;292(29):12010-12017. doi: 10.1074/jbc.R117.796862. Epub 2017 Jun 15. PubMed
2016 Publications
Dahl JU, Koldewey P, Bardwell JC, Jakob U. (2016) Detection of the pH-dependent Activity of Escherichia coli Chaperone HdeB In Vitro and In Vivo. J Vis Exp. 2016 Oct 23;(116). doi: 10.3791/54527. PubMed
Scott Horowitz & James C.A. Bardwell (2016) RNAs as chaperones RNA Biology, 13:12, 1228-1231, DOI: 10.1080/15476286.2016.1247147 PubMed
Johansson KE, Johansen NT, Christensen S, Horowitz S, Bardwell JC, Olsen JG, Willemoës M, Lindorff-Larsen K, Ferkinghoff-Borg J, Hamelryck T, Winther JR. (2016) Computational redesign of thioredoxin is hypersensitive towards minor conformational changes in the backbone template. J Mol Biol. 2016 Sep 19. pii: S0022-2836(16)30378-3. doi: 10.1016/j.jmb.2016.09.013. PubMed
Horowitz S, Koepnick B, Martin R, Tymieniecki A, Winburn AA, Cooper S, Flatten J, Rogawski DS, Koropatkin NM, Hailu TT, Jain N, Koldewey P, Ahlstrom LS, Chapman MR, Sikkema AP, Skiba MA, Maloney FP, Beinlich FR; Foldit Players; University of Michigan students, Popović Z, Baker D, Khatib F, Bardwell JC. (2016). Determining crystal structures through crowdsourcing and coursework. Nat. Commun.2016 Sep 16;7:12549. doi: 10.1038/ncomms12549. PubMed
This paper was the subject of a Marketplace Tech interview.
Sciore A, Su M, Koldewey P, Eschweiler JD, Diffley KA, Linhares BM, Ruotolo BT, Bardwell JC, Skiniotis G, Marsh EN. (2016) Flexible, symmetry-directed approach to assembling protein cages. PNAS. 2016 Aug 2;113(31):8681-6. doi: 10.1073/pnas.1606013113. Epub 2016 Jul 18. PubMed
Loïc Salmon, Logan S. Ahlstrom, Scott Horowitz, Alex Dickson, Charles L. Brooks, and James C. A. Bardwell. (2016) Capturing a dynamic chaperone-substrate interaction using NMR-informed molecular modeling JACS. DOI:10.1021/jacs.6b02382 Epub July 14, 2016 PubMed
Koldewey P, Stull F, Horowitz S, Martin R, Bardwell JCA. (2016) Forces Driving Chaperone Action. Cell. 2016 Jun 9. pii: S0092-8674(16)30657-2. doi: 10.1016/j.cell.2016.05.054. PubMed This paper was the subject of a News and Views [PDF] citation in NSMB by Patricia L. Clark and Adrian H. Elcock. 
Horowitz S, Salmon L, Koldewey P, Ahlstrom L, Martin R, Quan S, Afonine PV, van den Bedem H, Wang L, Xu Q, Trievel RC, Brooks CL, Bardwell JCA. (2016) Visualizing Chaperone-assisted Folding. Nature Struct. Mol. Biol. 2016 Jul;23(7):691-7. doi: 10.1038/nsmb.3237. Epub 2016 May 30. PubMed This paper was the subject of a News and Views citation in NSMB by Patricia L. Clark and Adrian H. Elcock. 
Docter BE, Horowitz S, Gray MJ, Jakob U, and Bardwell JCA (2016) Do Nucleic Acids Moonlight as Molecular Chaperones? Nucleic Acids Research. 2016 Jun 2;44(10):4835-45. doi: 10.1093/nar/gkw291. Epub 2016 Apr 21. PubMed
Groitl B, Horowitz S, Makepeace KA, Petrotchenko EV, Borchers CH, Reichmann D, Bardwell JC, Jakob U. (2016) Protein unfolding as a switch from self-recognition to high-affinity client binding. Nat Commun. 2016 Jan 20;7:10357. doi: 10.1038/ncomms10357. PMID: 26787517 PubMed
Stull F, Koldewey P, Humes JR, Radford SE, Bardwell JC. (2016). Substrate protein folds while it is bound to the ATP-independent chaperone Spy. Nat Struct Mol Biol. 2016 Jan;23(1):53-8. doi: 10.1038/nsmb.3133. Epub 2015 Nov 30. PMID: 26619265 PubMed This paper was the subject of a News and Views citation in NSMB by Patricia L. Clark and Adrian H. Elcock.
2015 Publications
Chatelle C, Kraemer S, Ren G, Chmura H, Marechal N, Boyd D, Roggemans C, Ke N, Riggs P, Bardwell J, Berkmen M. (2015) Converting a Sulfenic Acid Reductase into a Disulfide Bond Isomerase. Antioxid Redox Signal. 2015 Oct 20;23(12):945-57. doi: 10.1089/ars.2014.6235. Epub 2015 Jul 20. PubMed
Lennon CW, Thamsen M, Friman ET, Cacciaglia A, Sachsenhauser V, Sorgenfrei FA, Wasik MA, Bardwell JC. (2015) Folding Optimization In Vivo Uncovers New Chaperones. J Mol Biol. Sep 11;427(18):2983-94. doi: 10.1016/j.jmb.2015.05.013. Epub 2015 May 21. PMID: 26003922 PubMed
Dahl JU, Koldewey P, Salmon L, Horowitz S, Bardwell JC, Jakob U. (2015) HdeB functions as an acid-protective chaperone in bacteria. J Biol Chem. 2015 Apr 17;290(16):9950. PMID: 25888567 PubMed
Bardwell JC, Foit L, Malik A, Baumann T, Kern M. (2015) Methods and Compositions for Increasing Biological Molecule Stability. United States Patent No. US 8,986,997 B2. 2015 Mar 24.
2014 Publications
Malik A, Mueller-Schickert A, Bardwell JC. (2014) Cytosolic selection systems to study protein stability. J Bacteriol. 2014 Dec;196(24):4333-43. doi: 10.1128/JB.02215-14. Epub 2014 Sep 29. PMID: 25266385. PubMed
Horowitz S, Koldewey P, Bardwell JC. (2014) Undergraduates improve upon published crystal structure in class assignment Biochem Mol Biol Educ. 2014 Sep-Oct;42(5):398-404. doi: 10.1002/bmb.20811. Epub 2014 Jul 18. PMID: 25044946 PubMed
Gray MJ, Wholey WY, Wagner NO, Cremers CM, Mueller-Schickert A, Hock NT, Krieger AG, Smith EM, Bender RA, Bardwell JC, Jakob U. (2014) Polyphosphate is a primordial chaperone. Mol Cell. 6;53(5):689-99. Epub 2014 Feb 20. PMID:24560923. PubMed
Bardwell JC, Schreiber G. (2014) Editorial overview: Folding and binding. Curr Opin Struct Biol. 2014 Feb;24:viii-x. Epub 2014 Feb 6. No abstract available. PMID:24508004. PubMed
Quan S, Wang L, Petrotchenko EV, Makepeace KA, Horowitz S, Yang J, Zhang Y, Borchers CH, Bardwell JC. (2014) Super Spy variants implicate flexibility in chaperone action. Elife. 2014;3:e01584. Epub 2014 Feb 4. PMID:24497545. PubMed Discussed in the podcast “Flexible Friends” Episode 9
2013 Publications
Foit L, George JS, Zhang BW, Brooks CL 3rd, Bardwell JC. (2013) Chaperone activation by unfolding. Proc Natl Acad Sci U S A. 110(14):E1254-62. Epub 2013 Mar 4. PMCID:PMC3619340. PubMed This paper was the subject of a Commentary [PDF] by Karan S. Hingorani and Lila M. Gierasch.
Hailu TT, Foit L, Bardwell JC. (2013) In vivo detection and quantification of chemicals that enhance protein stability. Anal Biochem. 1;434(1):181-6. Epub 2012 Dec 5. PMCID:PMC3670414. PubMed
Foit L, Bardwell JC. . (2013) A tripartite fusion system for the selection of protein variants with increased stability in vivo. Methods Mol Biol. 978:1-20. PMID:23423885. PubMed
Quan S, Hiniker A, Collet JF, Bardwell JC. (2013) Isolation of bacteria envelope proteins. Methods Mol Biol. 966:359-66. PMID: 23299746. PubMed
2012 Publications
Evans ML, Schmidt JC, Ilbert M, Doyle SM, Quan S, Bardwell JC, Jakob U, Wickner S, Chapman MR. (2012) E. coli chaperones DnaK, Hsp33, and Spy inhibit bacterial functional amyloid assembly. Prion. 2011 Oct-Dec;5(4):323-34. doi: 10.4161/pri.18555. Epub 2011 Oct 1.
PMID: 22156728 PubMed
Bardwell JC, Jakob U. (2012) Conditional disorder in chaperone action. Trends Biochem Sci. 37(12):517-25. PMCID:PMC3508372.
Quan S, Bardwell JC. (2012) Chaperone discovery. Bioessays. 34(11):973-81. PMID: 22968800.