For a comprehensive list of publications, please visit Google Scholar.
§co-corresponding, *co-author
33. Knapp, M.; Jo, M.; Henthorn, C.L.; Brimberry, M.; Gnann, A.D.; Dowling, D.P.; Bridwell-Rabb, J., A Chlorophyllase from Arabidopsis thaliana Reveals an Emerging Model for Controlling Chlorophyll Hydrolysis, ACS Bio. Med. Chem. Au 2024, 4 (6), 353–370.
Recognition: Published as part of the 2024 Rising Stars in Biological, Medicinal, and Pharmaceutical Chemistry Special Issue
32. Fatima, S.;* Mehrafrooz, B.;* Boggs, D.G.; Ali, N.; Singh, S.; Thielges, M.C; Bridwell-Rabb, J.; Aksimentiev, A.; and Olshansky, L. Conformation-Dependent Hydrogen-Bonding Interactions in a Switchable Artificial Metalloprotein, Biochemistry 2024, 63 (16), 2040-2050.
31. Thompson, P.J.; Boggs, D.G.; Wilson, C.; Bruchs, A.; Velidandla, U.; Bridwell-Rabb, J.; Olshansky, L., Structure-Driven Development of a Biomimetic Rare Earth Artificial Metalloprotein, Proc. Natl. Acad. Sci. U. S. A. 2024, 121 (33), e2405836121.
30. Barroso*, G.T.; Garcia*, A.A.; Knapp, M.; Boggs, D.G.; Bridwell-Rabb, J. Purification and characterization of a Rieske oxygenase and its NADH-regenerating partner proteins, Methods Enzymol. 2024, https://doi.org/10.1016/bs.mie.2024.05.015.
29. Tian*, J.; Boggs*, D.G.; Donnan, P.H.; Barroso, G.T.; Garcia, A.A.; Dowling, D.P.; Buss, J.A.; Bridwell-Rabb, J. The NADH recycling enzymes TsaC and TsaD regenerate reducing equivalents for Rieske Oxygenase chemistry, J. Biol. Chem. 2023, 299 (10), 105222.
28. Tian, J.; Liu, J.; Knapp, M.; Donnan, P.H.; Boggs, D.G.; Bridwell-Rabb, J. Custom Tuning of Rieske Oxygenase Reactivity, Nat Commun 2023, 14, 5858.
27. Tian, J.; Garcia, A.A; Donnan, P.H.; Bridwell-Rabb, J. Leveraging a Structural Blueprint to Rationally Engineer the Rieske Oxygenase TsaM, Biochemistry 2023, 62 (11), 1807–1822.
Recognition: Front cover, https://pubs.acs.org/toc/bichaw/62/11
26. Jo*, M.; Knapp*, M.; Boggs*, D.G.; Brimberry, M.; Donnan, P.H.; Bridwell-Rabb, J. A Structure-function Analysis of Chlorophyllase Reveals a Mechanism for Activity Regulation Dependent on Disulfide Bonds, J. Biol. Chem. 2023, 299 (3), 102958.
25. Brimberry*, M.; Garcia*, A.A.; Liu, J.; Tian, J.; and Bridwell-Rabb, J. Engineering Rieske Oxygenase Activity One Piece at a Time, Curr. Opin. Chem. Biol. 2023, 72, 102227.
24. Knapp, M.; Bridwell-Rabb, J. The green pigment of life, Nat. Chem. 2022, 14, 1202.
23. Fatima, S.; Boggs, D.G.; Ali, N.; Thompson, P.J.; Thielges, M.C.; Bridwell-Rabb, J.; Olshansky, L., Engineering a Conformationally Switchable Artificial Metalloprotein, J. Am. Chem. Soc. 2022, 144 (47), 21606–21616. ChemRxiv: https://doi.org/10.26434/chemrxiv-2022-9qhw3
22. Liu, J.; Knapp, M.; Jo, M.; Dill, Z; Bridwell-Rabb, J., Rieske Oxygenase Catalyzed C-H Bond Functionalization Reactions in Chlorophyll b Biosynthesis, ACS Cent. Sci. 2022, 8 (10), 1393–1403.
Recognition: The in vitro Biosynthesis of Chlorophyll b via Enzyme Catalysis, ACS Central Science First Reactions: https://doi.org/10.1021/acscentsci.2c00997
Recognition: Highlighted by Science, DOI: 10.1126/science.ade4239
Recognition: Nature Synthesis pick of the week
21. Bridwell-Rabb§, J.; Li, B.; Drennan§, C. L., Cobalamin-Dependent Radical S-Adenosylmethionine Enzymes: Capitalizing on Old Motifs for New Functions, ACS Bio. Med. Chem. Au 2022, 2 (3), 173-186.
20. Dill, Z.; Li, B.; Bridwell-Rabb, J., Purification and structural elucidation of a cobalamin-dependent radical SAM enzyme, Methods Enzymol. 2022, 669, 91-116.
19. Li, B.; Jo, M.; Liu, J.; Tian, J.; Canfield, R.; Bridwell-Rabb, J., Structural and mechanistic basis for redox sensing by the cyanobacterial transcription regulator RexT, Commun. Biol. 2022, 5 (1), 275.
18. Liu, J.; Tian, J.; Perry, C.; Lukowski, A. L.; Doukov, T. I.; Narayan§, A. R. H.; Bridwell-Rabb§, J., Design principles for site-selective hydroxylation by a Rieske oxygenase, Nat. Commun. 2022, 13 (1), 255.
Recognition: Highlighted by Biological and Environmental Research Program Structural Biology and Imaging Resources https://berstructuralbioportal.org/highlight/specificity-and-selectivity-of-rieske- oxygenases/
17. Knapp, M.; Mendoza, J.; Bridwell-Rabb, J., An Unexplored Route for Aerobic C-H Bond Functionalization: The Rieske non-heme iron Oxygenases, Elsevier’s Encyclopedia of Biological Chemistry, 3rd edition, 2021, 413-424.
16. Boggs, D.; Bridwell-Rabb, J., A Radical exploration of the cobalamin-dependent radical SAM enzyme CysS, Trends in Chemistry, 2020, 12 (2), 1037-1040.
15. Lukowski*, A. L.; Liu*, J.; Bridwell-Rabb§, J.; Narayan§, A. R. H., Structural basis for divergent C-H hydroxylation selectivity in two Rieske oxygenases, Nat. Commun. 2020, 11 (1), 2991.
14. Rajendran, A.; Vaidya, K.; Mendoza, J.; Bridwell-Rabb, J.; Kamat, S. S., Functional Annotation of ABHD14B, an Orphan Serine Hydrolase Enzyme, Biochemistry 2020, 59 (2), 183-196.
Recognition: Future of Biochemistry: The Asia-Pacific Issue
13. Li, B.; Bridwell-Rabb, J., Aerobic Enzymes and Their Radical SAM Enzyme Counterparts in Tetrapyrrole Pathways, Biochemistry 2019, 58 (2), 85-93.
Recognition: Featured biography, research program, and cover image as part of the Future of Biochemistry issue
12. Bridwell-Rabb§, J.; Grell, T. A. J.; Drennan§, C. L., A Rich Man, Poor Man Story of S-Adenosylmethionine and Cobalamin Revisited, Annu. Rev. Biochem. 2018, 87, 555-584.
Mentored Publications
11. Das, D.; Patra, S.; Bridwell-Rabb, J.; Barondeau, D. P., Mechanism of frataxin “bypass” in human iron-sulfur cluster biosynthesis with implications for Friedreich’s ataxia, J. Biol. Chem. 2019, 294 (23), 9276-9284.
Recognition: Top 50 most viewed papers April-May 2019
10. Bridwell-Rabb*, J.; Zhong*, A.; Sun, H. G.; Drennan, C. L.; Liu, H. W., A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis, Nature 2017, 544 (7650), 322-326.
Recognition: Radical Ring Resizing Nature Chemical Biology 13, 569 (2017).
Recognition: Faculty of 1000 recommendations
9. Bridwell-Rabb§, J.; Drennan§, C. L., Vitamin B12 in the spotlight again, Curr. Opin. Chem. Biol. 2017, 37, 63-70.
8. Bridwell-Rabb, J.; Kang, G.; Zhong, A.; Liu, H. W.; Drennan, C. L., An HD domain phosphohydrolase active site tailored for oxetanocin-A biosynthesis, Proc. Natl. Acad. Sci. U. S. A. 2016, 113 (48), 13750-13755.
7. Bridwell-Rabb, J.; Drennan, C. L., A radically unexpected mechanism, Science 2016, 351 (6279), 1266-7.
6. Bowman*, S. E.; Bridwell-Rabb*, J.; Drennan, C. L., Metalloprotein Crystallography: More than a Structure, Acc. Chem. Res. 2016, 49 (4), 695-702.
Recognition: Selected Cover article
Recognition: ACS Editors’ Choice article
5. Bridwell-Rabb*, J.; Fox*, N. G.; Tsai*, C. L.; Winn, A. M.; Barondeau, D. P., Human frataxin activates Fe-S cluster biosynthesis by facilitating sulfur transfer chemistry, Biochemistry 2014, 53 (30), 4904-13.
Recognition: Highlighted Biochemistry article
4. Bridwell-Rabb, J.; Iannuzzi, C.; Pastore, A.; Barondeau, D. P., Effector role reversal during evolution: the case of frataxin in Fe-S cluster biosynthesis, Biochemistry 2012, 51 (12), 2506-14.
Recognition: Highlighted Biochemistry article
3. Bridwell-Rabb, J.; Winn, A. M.; Barondeau, D. P., Structure-function analysis of Friedreich’s ataxia mutants reveals determinants of frataxin binding and activation of the Fe-S assembly complex, Biochemistry 2011, 50 (33), 7265-74.
2. Tsai*, C. L.; Bridwell-Rabb*, J.; Barondeau, D. P., Friedreich’s ataxia variants I154F and W155R diminish frataxin-based activation of the iron-sulfur cluster assembly complex, Biochemistry 2011, 50 (29), 6478-87.
1. Wood*, T. L.; Bridwell-Rabb*, J.; Kim*, Y. I.; Gao, T.; Chang, Y. G.; LiWang, A.; Barondeau, D. P.; Golden, S. S., The KaiA protein of the cyanobacterial circadian oscillator is modulated by a redox-active cofactor, Proc. Natl. Acad. Sci. U. S. A. 2010, 107 (13), 5804-9.
Recognition: Featured in Texas A&M University Science News: Researchers Identify Key Protein-Cofactor Interactions in Bacterial Biological Clock