Kennedy Group Research
Welcome to the Kennedy Group homepage! Feel free to explore our website to develop a better understanding of our research projects and to obtain information about those working in the group.
As a bioanalytical chemistry lab, our goal is to develop analytical instrumentation and methods that can help solve problems of biological significance. The analytical techniques we investigate are based on microfluidics, chromatography, electrophoresis, mass spectrometry, and enzyme assays. These methods are applied to a variety of areas including endocrinology (e.g., understanding insulin secretion defects related to type 2 diabetes), neurochemistry (e.g., identifying neurochemical deficits associated with Huntington’s disease), and high-throughput screening for drug discovery and other applications.
In our work we must analyze complex mixtures, often at nanoliter volumes that contain only attomole or zeptomole quantities. These challenges create innumerable opportunities for analytical research. Students or post-docs with interest and skills in instrumentation, biology, analytical methods, organic chemistry, materials, and engineering can all contribute to the team.
Please follow the links to learn more about our projects related to analytical chemistry including lab-on-a chip, separations, and mass spectrometry and its applications in diabetes, neuroscience, and high-throughput screening.
Evaluation of surface treatments of PDMS Microfluidic devices for improving small-molecule recovery with application to monitoring metabolites secreted from islets of Langerhans.
ACS Measurement Science Au, 2023
Evaluation of analyte transfer between microfluidic droplets by mass spectrometry.
Analytical Chemistry, 2023
Screening clones for monoclonal antibody production using droplet microfluidics interfaced to electrospray ionization mass spectrometry.
Journal of the American Society for Mass Spectrometry, 2023
Two-dimensional liquid chromatography-mass spectrometry for lipidomics using off-line coupling of hydrophilic interaction liquid chromatography with 50 cm long reversed phase capillary columns.
Journal of Chromatography A, 2022
Monitoring hormone and small molecule secretion dynamics from islets-on-chip.
Analytical and Bioanalytical Chemistry, 2022
- Lab “Spotify Wrapped” 2021‘Tis the season for #SpotifyWrapped! Here are some groups and papers that inspired our grad students this year (in no particular order). Links to the papers are below •Castro, Nat Methods, 2021 •Fekete, J Chrom A, 2021 •Li, Nat Comm, 2020 •Schirmer, Anal Chem, 2020 •Xu, Anal Chem, 2021
- 2020 New StudentsWe are excited to announce that three new PhD students joined the Kennedy lab during the 2020-2021 academic year! Bridget Murray joins us from the University of Pittsburgh, and will be working on team high-throughput experimentation. Joe Naese joins us from Rowan University, where he worked with Kennedy lab alum Prof. Jim Grinias. Joe will … Read more
- NSF GRFP ResultsWe congratulate our group members for receiving offers and honorable mentions from the National Science Foundation Graduate Research Fellowship Program. Joshua Jones (incoming class of 2018) was awarded this prestigious fellowship for his proposed work in using liquid chromatography for the discovery of unique nucleosides. Josh performs this work between both the Kennedy and Koutmou groups. Additionally, … Read more