Single-Molecule Fluorescence Imaging: Molecular scale details help us to understand the macroscale

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The optics lab
Biteen Lab - Winter 2019
Plasmon-enhanced imaging in living cells
Understanding the human gut microbiome
Measuring DNA replication and repair
Quantifying metal nanoantenna mislocalization
Single-molecule super-resolution imaging
Developing new single-molecule methods
Plasmon-coupled polarization and spectrum reshaping

 

Real-Time, Super-Resolution in Microbiology and Nanophotonics

Molecules and their chemical interactions lie at the heart of the world around us. We are understanding biology, physics, and materials science on the molecular scale by bridging the gap between the scale of molecules and the traditional limits of light microscopy. Our research group addresses this fundamental challenge by developing single-molecule fluorescence imaging as a flexible, general technology for ultrahigh-resolution, real-time imaging.

Single-molecule methods have had high impact across the disciplines because they enable high-sensitivity measurements, eliminate heterogeneity in characterization, resolve positions on the nanometer scale, and characterize motions and features in situ—even in live cells. With these approaches, we are answering fundamental questions in bacterial cell biology and metal nanoparticle plasmonics.