Publications

Publications

  1. Liu X, Chen Y, Fierke CA. Inner-Sphere Coordination of Divalent Metal Ion with Nucleobase in Catalytic RNA. J Am Chem Soc. 2017 Dec 6;139(48):17457-17463. doi:10.1021/jacs.7b08755. Epub 2017 Nov 22. PMID:29116782.
  2. Castañeda CA, Wolfson NA, Leng KR, Kuo YM, Andrews AJ, Fierke CA. HDAC8 substrate selectivity is determined by long- and short-range interactions leading to enhanced reactivity for full-length histone substrates compared with peptides. J Biol Chem. 2017 Dec 29;292(52):21568-21577. doi: 10.1074/jbc.M117.811026. Epub 2017 Nov 6. PMID:29109148.
  3. Lopez JE, Haynes SE, Majmudar JD, Martin BR, Fierke CA. HDAC8 Substrates Identified by Genetically Encoded Active Site Photocrosslinking. J Am Chem Soc. 2017 Nov 15;139(45):16222-16227. doi: 10.1021/jacs.7b07603. Epub 2017 Nov 1. PMID:29035536.
  4. Niu S, Kim BC, Fierke CA, Ruotolo BT. Ion Mobility-Mass Spectrometry Reveals Evidence of Specific Complex Formation between Human Histone Deacetylase 8 and Poly-r(C)-binding Protein 1.Int J Mass Spectrom. 2017 Sep;420:9-15. doi: 10.1016/j.ijms.2016.12.017. Epub 2016 Dec 15.PMID:28983190.
  5. Castaneda CA, Lopez JE, Joseph CG, Scholle MD, Mrksich M, Fierke CA. Active Site Metal Identity Alters Histone Deacetylase 8 Substrate Selectivity: A Potential Novel Regulatory Mechanism. Biochemistry. 2017 Oct 24;56(42):5663-5670. doi: 10.1021/acs.biochem.7b00851. Epub 2017 Oct 12. PMID:28937750.
  6. Klemm BP, Karasik A, Kaitany KJ, Shanmuganathan A, Henley MJ, Thelen AZ, Dewar AJL, Jackson ND, Koutmos M, Fierke CA. Molecular recognition of pre-tRNA by Arabidopsis protein-only Ribonuclease P. RNA. 2017 Dec;23(12):1860-1873. doi: 10.1261/rna.061457.117. Epub 2017 Sep 5. PMID:28874505.
  7. Thompson RB, Fierke CA. Preface. Methods Enzymol. 2017;589:xvii-xviii. doi: 10.1016/S0076-6879(17)30107-6. No abstract available. PMID:28336076.
  8. Thompson RB, Fierke CA. Measuring and Imaging Metal Ions With Fluorescence-Based Biosensors: Speciation, Selectivity, Kinetics, and Other Issues. Methods Enzymol. 2017;589:281-299. doi: 10.1016/bs.mie.2017.01.003. Epub 2017 Mar 9. PMID: 28336067.
  9. Temple KJ, Wright EN, Fierke CA, Gibbs RA. Synthesis of Non-natural, Frame-Shifted Isoprenoid Diphosphate Analogues. Org Lett. 2016 Dec 2;18(23):6038-6041. Epub 2016 Nov 14. PMID:27934359.
  10. Chen Y, Liu X, Wu N, Fierke CA Fluorescence-Based Real-Time Activity Assays to Identify RNase P Inhibitors. Methods Mol Biol. 2017;1520:201-225. doi: 10.1007/978-1-4939-6634-9_12. PMID:27873254.
  11. Temple KJ, Wright EN, Fierke CA, Gibbs RA Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3503-7. doi: 10.1016/j.bmcl.2016.06.035. Epub 2016 Jun 15. PMID:27342751.
  12. Temple KJ, Wright EN, Fierke CA, Gibbs RA. Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3499-502. doi:10.1016/j.bmcl.2016.06.034. Epub 2016 Jun 16. PMID:27342750.
  13. Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC Jr, Noon K, Fierke CA, Williams CL. The tumor-suppressive small GTPase DiRas1 binds the noncanonical guanine nucleotide exchange factor SmgGDS and antagonizes SmgGDS interactions with oncogenic small GTPases. J Biol Chem. 2016 May 13;291(20):10948. doi: 10.1074/jbc.A115.696831. No abstract available. PMID:27197236.
  14. Klemm BP, Wu N, Chen Y, Liu X, Kaitany KJ, Howard MJ, Fierke CA. The Diversity of Ribonuclease P: Protein and RNA Catalysts with Analogous Biological Functions. Biomolecules. 2016 May 13;6(2). pii: E27. doi: 10.3390/biom6020027. Review. PMID:27187488.
  15. Howard MJ, Karasik A, Klemm BP, Mei C, Shanmuganathan A, Fierke CA, Koutmos M. Differential substrate recognition by isozymes of plant protein-only Ribonuclease P. RNA. 2016 Mar 10. [Epub ahead of print] PubMed PMID: 26966150.
  16. Alam N, Zimmerman L, Wolfson NA, Joseph CG, Fierke CA, Schueler-Furman O. Structure-Based Identification of HDAC8 Non-histone Substrates.Structure. 2016 Mar 1;24(3):458-68. doi: 10.1016/j.str.2016.02.002. PubMed PMID: 26933971.
  17. López JE, Sullivan ED, Fierke CA. Metal-dependent Deacetylases: Cancer and Epigenetic Regulators.ACS Chem Biol. 2016 Mar 18;11(3):706-16. doi: 10.1021/acschembio.5b01067. PubMed PMID: 26907466.
  18. Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC, Noon K, Fierke CA, Williams CL. The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases.J Biol Chem. 2016 Mar 18;291(12):6534-45. doi: 10.1074/jbc.M115.696831. Epub 2016 Jan 26. PubMed PMID:26814130.
  19. Gantt SM Fsgm, Decroos C, Lee MS, Gullett LE, Bowman CM, Christianson DW, Fierke CA. General Base-General Acid Catalysis in Human Histone Deacetylase 8. Biochemistry. 2016 Feb 9;55(5):820-832. Epub 2016 Jan 25. PubMed PMID: 26806311.
  20. Jennings BC, Danowitz AM, Wang YC, Gibbs RA, Distefano MD, Fierke CA. Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1333-6. doi: 10.1016/j.bmcl.2015.12.079. Epub 2015 Dec 22. PubMed PMID: 26803203.
  21. Karasik A, Shanmuganathan A, Howard MJ, Fierke CA, Koutmos M. Nuclear Protein-Only Ribonuclease P2 Structure and Biochemical Characterization Provide Insight into the Conserved Properties of tRNA 5′ End Processing Enzymes. J Mol Biol. 2016 Jan 16;428(1):26-40. doi: 10.1016/j.jmb.2015.11.025. Epub 2015 Dec 3. PubMed PMID: 26655022.
  22. Pithadia A, Brender JR, Fierke CA, Ramamoorthy A. Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives. J Diabetes Res. 2016;2016:2046327. doi: 10.1155/2016/2046327. Epub 2015 Nov 15. Review. PubMed PMID: 26649317.
  23. Pithadia AS, Bhunia A, Sribalan R, Padmini V, Fierke CA, Ramamoorthy A. Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes. Chem Commun (Camb). 2016 Jan 5;52(5):942-5. doi: 10.1039/c5cc07792c. PubMed PMID: 26587568.
  24. Daniel KB, Sullivan ED, Chen Y, Chan JC, Jennings PA, Fierke CA, Cohen SM. Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release. J Med Chem. 2015 Jun 11;58(11):4812-21. doi: 10.1021/acs.jmedchem.5b00539. Epub 2015 Jun 2. PubMed PMID: 25974739.
  25. Howard MJ, Klemm BP, Fierke CA. Mechanistic Studies Reveal Similar Catalytic Strategies for Phosphodiester Bond Hydrolysis by Protein-only and RNA-dependent Ribonuclease P. J Biol Chem. 2015 May 22;290(21):13454-64. doi: 10.1074/jbc.M115.644831. Epub 2015 Mar 27. PubMed PMID: 25817998.
  26. Ghosh A, Pithadia AS, Bhat J, Bera S, Midya A, Fierke CA, Ramamoorthy A, Bhunia A. Self-assembly of a nine-residue amyloid-forming peptide fragment of SARS corona virus E-protein: mechanism of self aggregation and amyloid-inhibition of hIAPP. Biochemistry. 2015 Apr 7;54(13):2249-61. doi: 10.1021/acs.biochem.5b00061. Epub 2015 Mar 24. PubMed PMID: 25785896.Engelke DR, Fierke CA. The evolution of RNase P. RNA. 2015 Apr;21(4):517-8. doi: 10.1261/rna.050732.115. PubMed PMID: 25780121.
  27. Mustoe AM, Liu X, Lin PJ, Al-Hashimi HM, Fierke CA, Brooks CL 3rd. Noncanonical secondary structure stabilizes mitochondrial tRNA(Ser(UCN)) by reducing the entropic cost of tertiary folding. J Am Chem Soc. 2015 Mar 18;137(10):3592-9. doi: 10.1021/ja5130308. Epub 2015 Mar 9. PubMed PMID: 25705930.
  28. Kim B, Pithadia AS, Fierke CA. Kinetics and thermodynamics of metal-binding to histone deacetylase 8. Protein Sci. 2015 Mar;24(3):354-65. doi: 10.1002/pro.2623. Epub 2015 Jan 13. PubMed PMID: 25516458.
  29. Liu X, Chen Y, Fierke CA. A real-time fluorescence polarization activity assay to screen for inhibitors of bacterial ribonuclease P. Nucleic Acids Res. 2014 Nov 10;42(20):e159. doi: 10.1093/nar/gku850. Epub 2014 Sep 23. PubMed PMID: 25249623.
  30. Olson DE, Udeshi ND, Wolfson NA, Pitcairn CA, Sullivan ED, Jaffe JD, Svinkina T, Natoli T, Lu X, Paulk J, McCarren P, Wagner FF, Barker D, Howe E, Lazzaro F, Gale JP, Zhang YL, Subramanian A, Fierke CA, Carr SA, Holson EB. An unbiased approach to identify endogenous substrates of “histone” deacetylase 8.ACS Chem Biol. 2014 Oct 17;9(10):2210-6. doi: 10.1021/cb500492r. Epub 2014 Aug 11. PubMed PMID: 25089360.
  31. Wang N, Lodge JM, Fierke CA, Mapp AK. Dissecting allosteric effects of activator-coactivator complexes using a covalent small molecule ligand.Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12061-6. doi: 10.1073/pnas.1406033111. Epub 2014 Jul 21. PubMed PMID: 25049401.
  32. Patel HR, Pithadia AS, Brender JR, Fierke CA, Ramamoorthy A. In Search of Aggregation Pathways of IAPP and Other Amyloidogenic Proteins: Finding Answers through NMR Spectroscopy.J Phys Chem Lett. 2014 Jun 5;5(11):1864-70. doi: 10.1021/jz5001775. Epub 2014 May 15. PubMed PMID: 26273866.
  33. Wolfson NA, Pitcairn CA, Sullivan ED, Joseph CG, Fierke CA. An enzyme-coupled assay measuring acetate production for profiling histone deacetylase specificity. Anal Biochem. 2014 Jul 1;456:61-9. doi: 10.1016/j.ab.2014.03.012. Epub 2014 Mar 25. PubMed PMID: 24674948.
  34. McCranor BJ, Szmacinski H, Zeng HH, Stoddard AK, Hurst T, Fierke CA, Lakowicz JR, Thompson RB. Fluorescence lifetime imaging of physiological free Cu(II) levels in live cells with a Cu(II)-selective carbonic anhydrase-based biosensor. Metallomics. 2014 May;6(5):1034-42. doi: 10.1039/c3mt00305a. PubMed PMID: 24671220.
  35. Dostál L, Kohler WM, Penner-Hahn JE, Miller RA, Fierke CA. Fibroblasts from long-lived rodent species exclude cadmium. J Gerontol A Biol Sci Med Sci. 2015 Jan;70(1):10-9. doi: 10.1093/gerona/glu001. Epub 2014 Feb 12. PubMed PMID: 24522391.
  36. Daniels KG, Tonthat NK, McClure DR, Chang YC, Liu X, Schumacher MA, Fierke CA, Schmidler SC, Oas TG. Ligand concentration regulates the pathways of coupled protein folding and binding. J Am Chem Soc. 2014 Jan 22;136(3):822-5. doi: 10.1021/ja4086726. Epub 2014 Jan 9. PubMed PMID: 24364358.
  37. Parisien M, Wang X, Perdrizet G 2nd, Lamphear C, Fierke CA, Maheshwari KC, Wilde MJ, Sosnick TR, Pan T. Discovering RNA-protein interactome by using chemical context profiling of the RNA-protein interface. Cell Rep. 2013 May 30;3(5):1703-13. doi: 10.1016/j.celrep.2013.04.010. Epub 2013 May 9. PubMed PMID: 23665222.
  38. Howard MJ, Liu X, Lim WH, Klemm BP, Fierke CA, Koutmos M, Engelke DR. RNase P enzymes: divergent scaffolds for a conserved biological reaction. RNA Biol. 2013 Jun;10(6):909-14. doi: 10.4161/rna.24513. Epub 2013 Apr 1. PubMed PMID: 23595059.
  39. Wang D, Fierke CA. The BaeSR regulon is involved in defense against zinc toxicity in E. coli. 2013 Apr;5(4):372-83. doi: 10.1039/c3mt20217h. PubMed PMID: 23446818.
  40. Zeng HH, Matveeva EG, Stoddard AK, Fierke CA, Thompson RB. Long wavelength fluorescence ratiometric zinc biosensor. J Fluoresc. 2013 May;23(3):375-9. doi: 10.1007/s10895-013-1161-6. PubMed PMID: 23345045.
  41. Wolfson NA, Pitcairn CA, Fierke CA. HDAC8 substrates: Histones and beyond. 2013 Feb;99(2):112-26. doi: 10.1002/bip.22135. PubMed PMID: 23175386; PubMed Central PMCID: PMC3507420.
  42. Zverina EA, Lamphear CL, Wright EN, Fierke CA. Recent advances in protein prenyltransferases: substrate identification, regulation, and disease interventions. Curr Opin Chem Biol. 2012 Dec;16(5-6):544-52. doi: 10.1016/j.cbpa.2012.10.015. Epub 2012 Nov 8. PubMed PMID: 23141597; PubMed Central PMCID: PMC3518607.
  43. Hougland JL, Gangopadhyay SA, Fierke CA. Expansion of protein farnesyltransferase specificity using “tunable” active site interactions: development of bioengineered prenylation pathways. J Biol Chem. 2012 Nov 2;287(45):38090-100. doi: 10.1074/jbc.M112.404954. Epub 2012 Sep 19. PubMed PMID: 22992747; PubMed Central PMCID: PMC3488079.
  44. Howard MJ, Lim WH, Fierke CA, Koutmos M. Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5′ processing. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16149-54. doi: 10.1073/pnas.1209062109. Epub 2012 Sep 18. PubMed PMID: 22991464; PubMed Central PMCID: PMC3479547.
  45. Subramanian T, Pais JE, Liu S, Troutman JM, Suzuki Y, Leela Subramanian K, Fierke CA, Andres DA, Spielmann HP. Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase. Biochemistry. 2012 Oct 16;51(41):8307-19. doi: 10.1021/bi3011362. Epub 2012 Oct 2. PubMed PMID: 22989235; PubMed Central PMCID: PMC3562418.
  46. Wang D, Hosteen O, Fierke CA. ZntR-mediated transcription of zntA responds to nanomolar intracellular free zinc. J Inorg Biochem. 2012 Jun;111:173-81. doi: 10.1016/j.jinorgbio.2012.02.008. Epub 2012 Feb 22. PubMed PMID: 22459916; PubMed Central PMCID: PMC3408962.
  47. McCranor BJ, Bozym RA, Vitolo MI, Fierke CA, Bambrick L, Polster BM, Fiskum G, Thompson RB. Quantitative imaging of mitochondrial and cytosolic free zinc levels in an in vitro model of ischemia/reperfusion. J Bioenerg Biomembr. 2012 Apr;44(2):253-63. doi: 10.1007/s10863-012-9427-2. Epub 2012 Mar 20. PubMed PMID: 22430627; PubMed Central PMCID: PMC3539817.
  48. Cheriyan M, Toone EJ, Fierke CA. Improving upon nature: active site remodeling produces highly efficient aldolase activity toward hydrophobic electrophilic substrates. Biochemistry. 2012 Feb 28;51(8):1658-68. doi: 10.1021/bi201899b. Epub 2012 Feb 16. PubMed PMID: 22316217; PubMed Central PMCID: PMC3315183.
  49. Yang Y, Wang B, Ucisik MN, Cui G, Fierke CA, Merz KM Jr. Insights into the mechanistic dichotomy of the protein farnesyltransferase peptide substrates CVIM and CVLS. J Am Chem Soc. 2012 Jan 18;134(2):820-3. doi: 10.1021/ja209650h. Epub 2012 Jan 6. PubMed PMID: 22206225; PubMed Central PMCID: PMC3277741.
  50. Guan X, Fierke CA. Understanding Protein Palmitoylation: Biological Significance and Enzymology. Sci China Chem. 2011 Dec;54(12):1888-1897. PubMed PMID: 25419213.
  51. Wang Y, Liu X, Schneider B, Zverina EA, Russ K, Wijeyesakere SJ, Fierke CA, Richardson RJ, Philbert MA. Mixed inhibition of adenosine deaminase activity by 1,3-dinitrobenzene: a model for understanding cell-selective neurotoxicity in chemically-induced energy deprivation syndromes in brain. Toxicol Sci. 2012 Feb;125(2):509-21. doi: 10.1093/toxsci/kfr317. Epub 2011 Nov 21. PubMed PMID: 22106038; PubMed Central PMCID: PMC3262860.
  52. London N, Lamphear CL, Hougland JL, Fierke CA, Schueler-Furman O. Identification of a novel class of farnesylation targets by structure-based modeling of binding specificity. PLoS Comput Biol. 2011 Oct;7(10):e1002170. doi: 10.1371/journal.pcbi.1002170. Epub 2011 Oct 6. PubMed PMID: 21998565; PubMed Central PMCID: PMC3188499.
  53. Cheriyan M, Walters MJ, Kang BD, Anzaldi LL, Toone EJ, Fierke CA. Directed evolution of a pyruvate aldolase to recognize a long chain acyl substrate. Bioorg Med Chem. 2011 Nov 1;19(21):6447-53. doi: 10.1016/j.bmc.2011.08.056. Epub 2011 Aug 30. PubMed PMID: 21944547; PubMed Central PMCID: PMC3209416.
  54. Wang D, Hurst TK, Thompson RB, Fierke CA. Genetically encoded ratiometric biosensors to measure intracellular exchangeable zinc in Escherichia coli. J Biomed Opt. 2011 Aug;16(8):087011. doi: 10.1117/1.3613926. PubMed PMID: 21895338; PubMed Central PMCID: PMC3166341.
  55. Marvin MC, Walker SC, Fierke CA, Engelke DR. Binding and cleavage of unstructured RNA by nuclear RNase P. RNA. 2011 Aug;17(8):1429-40. doi: 10.1261/rna.2633611. Epub 2011 Jun 10. PubMed PMID: 21665997; PubMed Central PMCID: PMC3153968.
  56. Koutmou KS, Day-Storms JJ, Fierke CA. The RNR motif of B. subtilis RNase P protein interacts with both PRNA and pre-tRNA to stabilize an active conformer. RNA. 2011 Jul;17(7):1225-35. doi: 10.1261/rna.2742511. Epub 2011 May 27. PubMed PMID: 21622899; PubMed Central PMCID: PMC3138560.
  57. Haider S, Joseph CG, Neidle S, Fierke CA, Fuchter MJ. On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis. Bioorg Med Chem Lett. 2011 Apr 1;21(7):2129-32. doi: 10.1016/j.bmcl.2011.01.128. Epub 2011 Feb 2. PubMed PMID: 21320778; PubMed Central PMCID: PMC3286521.
  58. Wands AM, Wang N, Lum JK, Hsieh J, Fierke CA, Mapp AK. Transient-state kinetic analysis of transcriptional activator·DNA complexes interacting with a key coactivator. J Biol Chem. 2011 May 6;286(18):16238-45. doi: 10.1074/jbc.M110.207589. Epub 2011 Feb 12. PubMed PMID: 21317429; PubMed Central PMCID: PMC3091231.
  59. Cole KE, Gattis SG, Angell HD, Fierke CA, Christianson DW. Structure of the metal-dependent deacetylase LpxC from Yersinia enterocolitica complexed with the potent inhibitor CHIR-090 . Biochemistry. 2011 Jan 18;50(2):258-65. Epub 2010 Dec 20. PubMed PMID: 21171638; PubMed Central PMCID: PMC3070812.
  60. Gattis SG, Hernick M, Fierke CA. Active site metal ion in UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) switches between Fe(II) and Zn(II) depending on cellular conditions. J Biol Chem. 2010 Oct 29;285(44):33788-96. doi: 10.1074/jbc.M110.147173. Epub 2010 Aug 13. PubMed PMID: 20709752; PubMed Central PMCID: PMC2962478.
  61. Dowling DP, Gattis SG, Fierke CA, Christianson DW. Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function . Biochemistry. 2010 Jun 22;49(24):5048-56. doi: 10.1021/bi1005046. PubMed PMID: 20545365; PubMed Central PMCID: PMC2895166.
  62. Hsieh J, Koutmou KS, Rueda D, Koutmos M, Walter NG, Fierke CA. A divalent cation stabilizes the active conformation of the B. subtilis RNase P x pre-tRNA complex: a role for an inner-sphere metal ion in RNase P. J Mol Biol. 2010 Jul 2;400(1):38-51. doi: 10.1016/j.jmb.2010.04.050. Epub 2010 Apr 29. PubMed PMID: 20434461; PubMed Central PMCID: PMC2939038.
  63. Hernick M, Gattis SG, Penner-Hahn JE, Fierke CA. Activation of Escherichia coli UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase by Fe2+ yields a more efficient enzyme with altered ligand affinity. Biochemistry. 2010 Mar 16;49(10):2246-55. doi: 10.1021/bi902066t. PubMed PMID: 20136146; PubMed Central PMCID: PMC2884013.
  64. Koutmou KS, Casiano-Negroni A, Getz MM, Pazicni S, Andrews AJ, Penner-Hahn JE, Al-Hashimi HM, Fierke CA. NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2479-84. doi: 10.1073/pnas.0906319107. Epub 2010 Jan 25. PubMed PMID: 20133747; PubMed Central PMCID: PMC2823894.
  65. Gantt SL, Joseph CG, Fierke CA. Activation and inhibition of histone deacetylase 8 by monovalent cations. J Biol Chem. 2010 Feb 26;285(9):6036-43. doi: 10.1074/jbc.M109.033399. Epub 2009 Dec 22. PubMed PMID: 20029090; PubMed Central PMCID: PMC2825397.
  66. Krzysiak AJ, Aditya AV, Hougland JL, Fierke CA, Gibbs RA. Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates. Bioorg Med Chem Lett. 2010 Jan 15;20(2):767-70. doi: 10.1016/j.bmcl.2009.11.011. Epub 2009 Nov 12. PubMed PMID: 20005705; PubMed Central PMCID: PMC2922960.
  67. Koutmou KS, Zahler NH, Kurz JC, Campbell FE, Harris ME, Fierke CA. Protein-precursor tRNA contact leads to sequence-specific recognition of 5′ leaders by bacterial ribonuclease P. J Mol Biol. 2010 Feb 12;396(1):195-208. doi: 10.1016/j.jmb.2009.11.039. Epub 2009 Nov 28. PubMed PMID: 19932118; PubMed Central PMCID: PMC2829246.
  68. Hougland JL, Hicks KA, Hartman HL, Kelly RA, Watt TJ, Fierke CA. Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities. J Mol Biol. 2010 Jan 8;395(1):176-90. doi: 10.1016/j.jmb.2009.10.038. Epub 2009 Oct 28. PubMed PMID: 19878682; PubMed Central PMCID: PMC2916699.
  69. Hurst TK, Wang D, Thompson RB, Fierke CA. Carbonic anhydrase II-based metal ion sensing: Advances and new perspectives. Biochim Biophys Acta. 2010 Feb;1804(2):393-403. doi: 10.1016/j.bbapap.2009.09.031. Epub 2009 Oct 8. Review. PubMed PMID: 19818877; PubMed Central PMCID: PMC2818387.
  70. Hsieh J, Fierke CA. Conformational change in the Bacillus subtilis RNase P holoenzyme–pre-tRNA complex enhances substrate affinity and limits cleavage rate. RNA. 2009 Aug;15(8):1565-77. doi: 10.1261/rna.1639409. Epub 2009 Jun 23. PubMed PMID: 19549719; PubMed Central PMCID: PMC2714742.
  71. Johnson KM, Swenson L, Opipari AW Jr, Reuter R, Zarrabi N, Fierke CA, Börsch M, Glick GD. Mechanistic basis for differential inhibition of the F1Fo-ATPase by aurovertin. Biopolymers. 2009 Oct;91(10):830-40. doi: 10.1002/bip.21262. PubMed PMID: 19462418; PubMed Central PMCID: PMC2757082.
  72. Hougland JL, Fierke CA. Getting a handle on protein prenylation. Nat Chem Biol. 2009 Apr;5(4):197-8. doi: 10.1038/nchembio0409-197. PubMed PMID: 19295521.
  73. Hougland JL, Lamphear CL, Scott SA, Gibbs RA, Fierke CA. Context-dependent substrate recognition by protein farnesyltransferase. Biochemistry. 2009 Mar 3;48(8):1691-701. doi: 10.1021/bi801710g. PubMed PMID: 19199818; PubMed Central PMCID: PMC2765569.
  74. Bozym R, Hurst TK, Westerberg N, Stoddard A, Fierke CA, Frederickson CJ, Thompson RB. Determination of zinc using carbonic anhydrase-based fluorescence biosensors. Methods Enzymol. 2008;450:287-309. doi: 10.1016/S0076-6879(08)03414-9. PubMed PMID: 19152866.
  75. Hsieh J, Walker SC, Fierke CA, Engelke DR. Pre-tRNA turnover catalyzed by the yeast nuclear RNase P holoenzyme is limited by product release. RNA. 2009 Feb;15(2):224-34. doi: 10.1261/rna.1309409. Epub 2008 Dec 17. PubMed PMID: 19095620; PubMed Central PMCID: PMC2648709.
  76. Dowling DP, Gantt SL, Gattis SG, Fierke CA, Christianson DW. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry. 2008 Dec 23;47(51):13554-63. doi: 10.1021/bi801610c. PubMed PMID: 19053282; PubMed Central PMCID: PMC2635894.
  77. Lipton AS, Heck RW, Hernick M, Fierke CA, Ellis PD. Residue ionization in LpxC directly observed by 67Zn NMR spectroscopy. J Am Chem Soc. 2008 Sep 24;130(38):12671-9. doi: 10.1021/ja801776c. Epub 2008 Aug 30. PubMed PMID: 18761443; PubMed Central PMCID: PMC2652226.
  78. Mason AB, Judson GL, Bravo MC, Edelstein A, Byrne SL, James NG, Roush ED, Fierke CA, Bobst CE, Kaltashov IA, Daughtery MA. Evolution reversed: the ability to bind iron restored to the N-lobe of the murine inhibitor of carbonic anhydrase by strategic mutagenesis. Biochemistry. 2008 Sep 16;47(37):9847-55. doi: 10.1021/bi801133d. Epub 2008 Aug 20. PubMed PMID: 18712936; PubMed Central PMCID: PMC2669928.
  79. Hernick M, Fierke CA. A method to assay inhibitors of lipopolysaccharide synthesis. Methods Mol Med. 2008;142:143-54. doi: 10.1007/978-1-59745-246-5_12. PubMed PMID: 18437312.
  80. Inamdar MV, Lastoskie CM, Fierke CA, Sastry AM. Mobile trap algorithm for zinc detection using protein sensors. J Chem Phys. 2007 Nov 14;127(18):185102. PubMed PMID: 18020665.
  81. Walters MJ, Srikannathasan V, McEwan AR, Naismith JH, Fierke CA, Toone EJ. Characterization and crystal structure of Escherichia coli KDPGal aldolase. Bioorg Med Chem. 2008 Jan 15;16(2):710-20. Epub 2007 Oct 18. PubMed PMID: 17981470; PubMed Central PMCID: PMC3326530.
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  187. Heming TA, Vanoye CG, Stabenau EK, Roush ED, Fierke CA, Bidani A. Inhibitor sensitivity of pulmonary vascular carbonic anhydrase. J Appl Physiol. 1993 Oct;75(4):1642-9. PubMed PMID: 8282615.
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  192. Roush ED, Fierke CA. Purification and characterization of a carbonic anhydrase II inhibitor from porcine plasma. Biochemistry. 1992 Dec 15;31(49):12536-42. PubMed PMID: 1463741.
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  195. Krebs JF, Fierke CA, Alexander RS, Christianson DW. Conformational mobility of His-64 in the Thr-200—-Ser mutant of human carbonic anhydrase II. Biochemistry. 1991 Sep 24;30(38):9153-60. PubMed PMID: 1909891.
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  197. Venters RA, Calderone TL, Spicer LD, Fierke CA. Uniform 13C isotope labeling of proteins with sodium acetate for NMR studies: application to human carbonic anhydrase II. Biochemistry. 1991 May 7;30(18):4491-4. PubMed PMID: 1902380.
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  199. Fierke CA, Benkovic SJ. Probing the functional role of threonine-113 of Escherichia coli dihydrofolate reductase for its effect on turnover efficiency, catalysis, and binding. Biochemistry. 1989 Jan 24;28(2):478-86. PubMed PMID: 2496745.
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  201. Fierke CA, Johnson KA, Benkovic SJ. Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli. Biochemistry. 1987 Jun 30;26(13):4085-92. PubMed PMID: 3307916.
  202. Fierke CA, Kuchta RD, Johnson KA, Benkovic SJ. Implications for enzymic catalysis from free-energy reaction coordinate profiles. Cold Spring Harb Symp Quant Biol. 1987;52:631-8. PubMed PMID: 3331348.
  203. Mayer RJ, Chen JT, Taira K, Fierke CA, Benkovic SJ. Importance of a hydrophobic residue in binding and catalysis by dihydrofolate reductase. Proc Natl Acad Sci U S A. 1986 Oct;83(20):7718-20. PubMed PMID: 3463995; PubMed Central PMCID: PMC386792.
  204. Fierke CA, Jencks WP. Two functional domains of coenzyme A activate catalysis by coenzyme A transferase. Pantetheine and adenosine 3′-phosphate 5′-diphosphate. J Biol Chem. 1986 Jun 15;261(17):7603-6. PubMed PMID: 3458707.
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