Welcome to the Keane Lab!
RNA molecules play important roles in nearly all aspects of biology and disease including regulatory roles in translation, splicing, and epigenetics. Additionally, RNAs can be catalytic or serve as molecular scaffolds for attracting macromolecular binding partners. Importantly, it has been shown that RNAs are drugable and may serve as exciting targets for small molecule inhibitors given their myriad important roles in biology.
We are broadly interested in understanding the function of noncoding RNAs. In order to understand the mechanism of function, we must first understand structure. Our lab utilizes a diverse toolkit of biochemical and biophysical techniques with a focus on utilizing NMR spectroscopy to study RNA structure and folding.