For a full list of publications, please visit Google Scholars or PubMed.

Keane Lab Publications:

15. Kladwang, W., Topkar, V.V., Liu, B., Hodges, T.L., Keane, S.C., al-Hashimi, H., Das, R. Anomalous reverse transcription through chemical modifications in polyadenosine stretches. bioRxiv (2020)

14. Kotar, A., Foley, H.N., Baughman, K.M., Keane, S.C. Advanced approaches for elucidating structures of large RNAs using NMR spectroscopy and complementary methods. Methods In Press (2020)

13. Meagher, J.L., Takata, M., Gonçalves-Carneiro, D., Keane, S.C., Rebendenne, A., Ong, H., Orr, V.K., MacDonald, M.R., Stuckey, J.A., Bieniasz, P.D., Smith, J.L. Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences. PNAS 113, 24303-24309 (2019)

12. Zhang, H. and Keane, S.C. Advances that facilitate the study of large RNA structure and dynamics by nuclear magnetic resonance spectroscopy. WIRES RNA 10:e1541 (2019)

Papers published prior to the University of Michigan

11. Zhang, K.*, Keane, S.C.*, Su, Z., Irobalieva, R.N., Chen, M., Van, V., Sciandra, C.A., Marchant, J., Heng, X., Schmid, M.F., Case, D.A., Ludtke, S.J., Summers, M.F., Chiu, W. Structure of the 30 kDa HIV-1 RNA Dimerization Signal by a Hybrid Cryo-EM, NMR, and Molecular Dynamics Approach. Structure 26,490-498.e3 (2018)

10. Keane, S.C. and Summers, M.F. NMR studies of the structure and function of the HIV-1 5′-leader. Viruses 8; v8120338 (2016)

9. Keane, S.C., Van, V., Frank, H.M., Sciandra, C.A., McCowin, S., Santos, J., Heng, X., Summers, M.F. NMR detection of intermolecular interaction sites in the dimeric 5′-leader of the HIV-1 genome. PNAS 113, 13033-13038 (2016).

8. Carlson, L.A., Bai, Y., Keane, S.C., Doudna, J.A., Hurley, J.H. Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies. eLife 5:e14663 (2016)

7. Keane, S.C., Heng, X., Lu, K., Kharytonchyk, S., Ramakrishnan, V., Carter, G., Barton, S., Hosic, A., Florwick, A., Santos, J., Bolden, N.C., McCowin, S., Case, D.A., Johnson, B., Salemi, M., Telesnitsky, A., Summers, M.F. Structure of the HIV-1 RNA Packaging Signal. Science 348, 917-921 (2015).

6. Alvarado, L.J., LeBlanc, R.M., Longhini, A.P., Keane, S.C., Niyati, J., Yildiz, Z.F., Tolbert, B.S., D’Souza, V.M., Summers, M.F., Kreutz, C., Dayie, T.K. Regio-selective Chemical-Enzymatic Synthesis of Pyrimidine Nucleotides Facilitates RNA Structure and Dynamics Studies. ChemBioChem 15, 1573-1577 (2014).

5. Keane, S.C. and Giedroc, D.P. Solution Structure of Mouse Hepatitis Virus (MHV) nsp3a and Determinants of the Interaction with MHV Nucleocapsid (N) Protein. J. Virol. 87, 3502-3515 (2013).

4. Keane, S.C. and Giedroc, D.P. (1)H, (13)C, (15)N resonance assignments of murine hepatitis virus nonstructural protein 3a. Biomol NMR Assign. 8, 15-17 (2014).

3. Keane, S.C., Liu, P., Leibowitz, J.L., Giedroc, D.P. Functional transcriptional regulatory sequence (TRS) RNA binding and helix destabilizing determinants of murine hepatitis virus (MHV) nucleocapsid (N) protein. J. Biol. Chem. 287, 7063-7073 (2012).

2. Grossoehme, N.E., Li, L., Keane, S.C., Liu, P., Dann, C.E. 3rd, Leibowitz, J.L., Giedroc, D.P. Coronavirus N protein N-terminal domain (NTD) specifically binds the transcriptional regulatory sequence (TRS) and melts TRS-cTRS RNA duplexes. J. Mol. Biol. 394, 544-57 (2009)

1. Liu, P., Li, L., Keane, S.C., Yang, D., Leibowitz, J.L., Giedroc, D.P. Mouse hepatitis virus stem-loop 2 adopts a uYNMG(U)a-like tetraloop structure that is highly functionally tolerant of base substitutions. J. Virol. 83, 12084-12093 (2009).