Publications

At U of M (09/2016-present)^: corresponding author, *: equal contribution,  __: Undergraduate students, Blue: Graduate students

  1. Chen L., Henn D., Dong Z., Wielenga A., Liang J, Dias do Vale G., Burugula B., Zou J., Krishnan Y., McDonald J., Kitzman J., and Li M.^(2026) Peroxisome-derived ether lipids regulate lysosomal exocytosis, EMBO Journal, Accepted
  2. Yang X*, Doray B*, Henn D,* Venkatarangan V*, Jennings BC, Liang J,  Zhang W, Zhang B, Yu L, Chen L, Kornfeld S, Li M.^ (2026) Molecular Insights into the Regulation of GNPTAB by TMEM251 Nature Comm., Accepted
  3. Baraj D., Henn D., Yang X., Li M., and Dickson P. (2025) Protocol to measure endogenous GlcNAc-1-phosphotransferase activity in SK-MEL-30 cells,  STAR Protoc. 2025 Jul 9;6(3):103935.
  4. Henn D., Yang X., and Li M.^(2025) Lysosomal quality control, Autophagy, 2025 Jul;21(7):1413-1432.
  5. Baraj D.^, Jennings BC., Yang X., Liu L., Venkatarangan V., Kornfeld S., and Li M^ (2025) LYSET facilitates integration of both the N- and C-terminal transmembrane helices/cytoplasmic domains of GlcNAc-1-phosphotransferase., MBoC, 2025 Apr 1;36(4):br12.
  6. Arines FM*, Wielenga A*, Stockbridge RB, Li M.^ (2024) Protocol for purifying and reconstituting a vacuole membrane transporter Ypq1 into proteoliposomes. STAR Protoc. 2024 Dec 20;5(4):103483.
  7. FM Arines, A Wielenga, Henn D, OE Burata, FN Garcia, RB Stockbridge, Li M.^(2024)  Lysosome transporter purification and reconstitution identifies Ypq1 as a pH-gated lysine transporter. MBoC, 2024 Mar 1;35(3):ar28.
  8. Fang S, Chen G, Wang Y, Ganti R, Chernova TA, Zhou L, Jacobs SE, Duong D, Kiyokawa H, Chernoff YO, Li M, Shcherbik N, Zhao B, Yin J.^ (2023) Profiling and verifying the substrates of E3 ubiquitin ligase Rsp5 in yeast cells. STAR Protoc. 2023 Aug 9;4(3):102489.
  9. Venkatarangan V., Zhang W., Yang X., Thoene J., Hahn S., Li M.^(2023) ER-associated degradation in cystinosis pathogenesis and the prospects of precision medicine. J Clin. Invest., In press, News Release: https://news.umich.edu/rare-disease-shares-mechanism-with-cystic-fibrosis/
  10. Zhang B., Yang X., Li M.^ (2023) LYSET/TMEM251/GCAF is critical for autophagy and lysosomal function by regulating the mannose-6-phosphate (M6P) pathway. Autophagy doi: 10.1080/15548627.2023.2167375. Written by an awesome undergrad Bokai Zhang
  11. Zhang W*., Yang X*., Li Y., Yu L., Zhang B., Zhang J., Cho W., Venkatarangan V., Chen L., Burugula B., Bui S., Wang Y., Duan C., Kitzman J. and Li M.^ (2022) GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway. Nature Comm., 13(1):5351. PMCID: PMC9468337, Featured by “Editors’ Highlights“, recommended by Faculty Opinions, and reported by many news channels. https://news.umich.edu/missing-pathway-in-lysosome-underlies-newly-discovered-human-disease/ https://www.nature.com/articles/s41467-022-33025-1/metrics
  12. Arines F.M^. and Li M^. (2022) An optimized protocol to analyze membrane protein degradation in yeast using quantitative Western blot and flow cytometry. STAR Protocols. In press
  13. Zhang W., Yang X., Chen L., Liu Y., Venkatarangan V., Reist L., Hanson P., Xu H., Wang Y., and Li M.^ (2021) A conserved ubiquitin- and ESCRT-dependent pathway to regulate human lysosomal membrane proteins. PLOS Biology. 19(7): e3001361. PMCID: PMC8337054
  14. Yang X., Reist L*., Chomchai D*., Chen L., Arines F.M., and Li M^. (2021) ESCRTs, not intralumenal structures, are important for the degradation of vacuole membrane and plasma membrane transporters. J Cell Biol. 220(8) Highlighted by a Spotlight article.
  15. Wang Y., Fang S., Chen G., Ganti R., Chernova T., Zhou L., Duong D., Kiyokawa H., Li M., Zhao B., Shcherbik N.,Chernoff Y., Yin J. (2021) Regulation of the endocytosis and prion-chaperoning machineries by yeast E3 ubiquitin ligase Rsp5 as revealed by orthogonal ubiquitin transfer. Cell Chemical Biol. In press
  16. Arines F.M., Hamlin A., Yang X., Liu Y., and Li M^. (2021) A selective transmembrane recognition mechanism by a membrane-anchored ubiquitin ligase adaptor. J Cell Biol. 220(1) Highlighted by a Spotlight article
  17. Yang X*., Zhang W*., Wen X., Bulinski PJ, Chomchai D., Arines F., Liu Y., Sprenger S., Teis D., Klionsky D., and  Li M^.(2020) TORC1 regulates vacuole membrane composition through ubiquitin- and ESCRT-dependent microautophagy J. Cell Biol. 219(3) Recommended by Faculty Opinions
  18. Suzuki SW*, Chuang YS*, Li M., Seaman MNJ, and  Emr SD.(2019) A bipartite sorting signal ensures specificity of retromer complex in membrane protein recycling,  J. Cell Biol. 218(9) 2876-2886
  19. Yang X., Arines FM., Zhang W., and Li M^. (2018) Sorting of a Multi-subunit Ubiquitin Ligase Complex in the Endolysosome System, eLife pii: e33116.
  20. Zhu L*., Jorgensen JR*., Li M., Chuang YS., Emr SD.(2017) ESCRTs function directly on the lysosome membrane to downregulate ubiquitinated lysosomal membrane proteins, eLife  pii: e26403

  Before U of M