Publications

  Representative publications from a list of over 200

                                           

2019

Kawa, A.B., Allain, F., Robinson, T.E. and Samaha, A. The transition to cocaine addiction: the importance of pharmacokinetics for preclinical models.Psychopharmacology, 2019, 1-13.

Hughson, A.R., Horvath, A.P., Holl, K., Palmer, A., Woods, L.C., Robinson, T.E. and Flagel, S.B. Incentive salience attribution, “sensation-seeking” and “novelty-seeking” are independent traits in  a large sample of male and female heterogeneous stock rats.Scientific Reports, 2019, 9, 2351.

Kawa, A.B. and Robinson, T.E. Sex differences incentive-sensitization produced by intermittent access cocaine self-administration. Psychopharmacology, 2019, 236, 625-639.

Fitzpatrick, C.J., Jagannathan, L., Lowenstein, E.D., Robinson, T.E., Becker, J.B. and Morrow, J.D. Single prolonged stress decreases sign-tracking and cue-induced reinstatement of cocaine-seeking. Behavioural Brain Research, 2019, 359, 799-806.

2018

Pitchers, K.K., Sarter, M. and Robinson, T.E. The hot ‘n’ cold of cue-induced drug relapse.Learning & Memory, 2018, 25, 474-480.

Cogan, E.S., Shapses, M.A., Robinson, T.E. and Tronson, N.C. Disrupting reconsolidation: memory erasure or blunting of emotional/motivational value.Neuropsychopharmacology, 2018, 10.

Ahrens, A.M., Ferguson, L.M., Robinson, T.E. and Aldridge, J.W. Dynamic Encoding of Incentive Salience in the Ventral Pallidum: Dependence of the Form of the Reward Cue. eNeuro, 2018, 5.

Kolb, B., Li, Y., Robinson, T.E. and Parker, L. THC alters morphology of neurons in medial prefrontal cortex, orbital prefrontal cortex, and nucleus accumbens and alters the ability of later experience to promote structural plasticity. Synapse, 2018, 72.

Singer, B.F., Fadanelli, M., Kawa, A.B. and Robinson, T.E. Are cocaine-seeking “habits” necessary for the development of addiction-like behavior in rats?Journal of Neuroscience, 2018, 38, 60-73.

Badiani, A., Berridge, K.C., Heilig, M., Nutt, D.J. and Robinson, T.E. Addiction research and theory: a commentary on the Surgeon General’s Report on alcohol, drugs, and health.Addiction Biology, 2018, 23, 3-5.

2017

Pitchers, K.K., Kane, L.F., Kim, Y., Robinson, T.E. and Sarter, M. ‘Hot’vs. ‘cold’ behavioral-cognitive styles: motivational-dopaminergic vs. cognitive-cholinergic processing of a Pavlovian cocaine cue in sign-and goal-tracking rats.European Journal of Neuroscience, 2017, 46, 2768-2781.

Pitchers, K.K., Phillips, K.B., Jones, J.L., Robinson, T.E. and Sarter, M. Diverse roads to relapse: a discriminative cue signaling cocaine availability is more effective in renewing cocaine seeking in goal trackers than sign trackers and depends on basal forebrain cholinergic activity.Journal of Neuroscience, 2017, 37, 7198-7208.

Singer, B.F., Bryan, M.A., Popov, P., Robinson, T.E. and Aragona, B.J. Rapid induction of dopamine sensitization in the nucelus accumbens shell induced by a single injection of cocaine.Behavioural Brain Research, 2017, 324, 66-70.

Pitchers, K.K., Wood, T.R., Skrzynski, C.J., Robinson, T.E. and Sarter, M. The ability for cocaine and cocaine-associated cues to compete for attention. Behavioral brain research, 2017, 320, 302-315.

Flagel, S.B. and Robinson, T.E. Neurobiological basis of individual variation in stimulus-reward learning. Current opinion in behavioral sciences, 2017, 13, 178-185.

2016

Berridge, K.C. and Robinson, T.E. Liking, wanting and the incentive-sensitization theory of addiction. American psychologist, 2016, 71, 670.

Singer, B.F., Bryan, M.A., Popov, P., Scarff, R., Carter, C., Wright, E., Aragona, B.J. and Robinson, T.E. The sensory features of a food cue infuence its ability to act as an incentive stimulus and evoke dopamine release in the nucleus accumbens core.Learning & Memory, 2016, 23, 595-606.

Kawa, A.B., Bentzley, B.S. and Robinson, T.E. Less is more: prolonged intermittent access cocaine self-administration produces incentive-sensitization and addiction-like behavior.Psychopharmacology, 2016, 233, 3587-3602.

Ahrens, A.M., Meyer, P.J., Ferguson, L.M., Robinson, T.E. and Aldridge, J.W. Neural activity in the ventral pallidum encodes variation in the incentive value of a reward cue.Journal of Neuroscience, 2016, 36, 7957-7970.

Ahrens, A.M., Singer, B.F., Fitzpatrick, C.J., Morrow, J.D. and Robinson, T.E. Rats that sign-track are resistant to Pavlovian but not instrumental extinction. Behavioral brain research, 2016, 296, 418-430.

2015

Yager, L.M. and Robinson, T.E. Individual variation in the motivational properties of a nicotine cue: sign-trackers vs. goal-trackers.Psychopharmacology, 2015, 232, 3149-3160.

Yager, L.M., Pitchers, K.K., Flagel, S.B. and Robinson, T.E. Individual variation in the motivational and neurobiological effects on an opioid cue.Neuropsychopharmacology, 2015, 40, 1269.

Pitchers, K.K., Flagel, S.B, O’Donnell, E.G., Woods, L.C., Sarter, M. and Robinson, T.E. Individual variation in the propensity to attriute incentive salience to a food cue: influence of sex.Behavioural brain research, 2015, 278, 462-469.

Morrow, J.D., Saunders, B.T., Maren, S. and Robinson, T.E. Sign-tracking to an appetitive cue predicts incubation of conditioned fear in rats.Behavioural brain research, 2015, 276, 59-66.

2014

Saunders, B.T., O’donnell, E.G., Aurbach, E.L. and Robinson, T.E. A cocaine context renews drug seeking preferentially in a subset of individuals.Neuropsychopharmacology, 2014, 39, 2816.

Meyer, P.J., Cogan, E.S., and Robinson, T.E. The form of a conditioned stimulus can influence the degree to which it acquires incentive motivational properties. PloS one, 2014, 9, e98163.

Lesaint, F., Sigaud, O., Flagel, S.B, Robinson, T.E. and Mehdi, K. Modelling individual differences in the form of Pavlovian conditioned approach responses: a dual learning systems approach with factored representations.PLoS computational biology, 2014, 10, e1003466.

Robinson, T.E., Yager, L.M., Cogan, E.S. and Saunders, B.T. On the motivational properties of reward cues: individual differences.Neuropharmacology, 2014, 76, 450-459.

2013

Saunders, B.T. and Robinson, T.E. Individual variation in resisting temptation: implications for addiction.Neuroscience & Biobehavioral Reviews, 2013, 37, 1955-1975.

Fitzpatrick, C.J., Gopalakrishnan, S., Cogan, E.S., Yager, L.M., Meyer, P.J., Lovic, V., Saunders, B.T., Parker, C.C., Gonzales, N.M., Aryee, E., Flagel, S.B., Palmer, A.A., Robinson, T.E. and Morrow, J.D. Variation in the form of Pavlovian conditioned approach behavior among outbred male Sprague-Dawley rats from different vendors and colonies: sign-tracking vs. goal-tracking.PloS one, 2013, 8, 10.

2012

Jedynak, J.P., Cameron, C.M. & Robinson, T.E. Repeated methamphetamine administration differentially alters Fos expression in caudate-putamen patch and matrix compartments and nucleus accumbens. PLoS ONE, 2012, 7, e34227.

Meyer, P.J., Lovic, V., Saunders, B.T., Yager, Lindsay, L.M., Flagel, S.B., Morrow, J.D. and Robinson, T.E. Quantifying individual variation in the propensity to attribute incentive salience to reward cues. PLoS ONE, 2012, 7, e38987.

Saunders, B.T. and Robinson, T.E. The role of dopamine in the accumbens core in the expression of Pavlovian-conditioned responses. European Journal of Neuroscience, 2012, 36, 2521-2532.

Meyer, P.J., Ma, S.T. and Robinson, T.E. A cocaine cue is more preferred and evokes more frequency-modulated 50-kHz ultrasonic vocalizations in rats prone to attribute incentive salience to a food cue. Psychopharmacology, 2012, 219, 999-1009.

2011

Flagel, S.B., Cameron, C.M., Pickup, K.N., Watson, S.J., Akil, H. and Robinson, T.E. A food predictive cue must be attributed with incentive salience for it to induce c-fos mRNA expression in cortico-striatal-thalamic brain regions. Neuroscience, 2011, 196, 80-96.

Flagel, S.B., Clark, J.J., Robinson, T.E., Mayo, l., Czuj, A., Willuhn, I., Akers, C.A., Clinton, S.M., Phillips, P.E.M. and Akil, H. A selective role for dopamine in stimulus-reward learning. Nature, 2011, 469, 53-59

Lomanowska, A.M., Lovic, V., Rankine, M.J., Mooney, S.J., Robinson, T.E. and Kraemer, G.W. Inadequate early social experience increases the incentive salience of reward-related cues in adulthood. Behavioural Brain Research, 2011, 220, 91-99.

Morrow, J.D., Maren, S. and Robinson, T.E. Individual variation in the propensity to attribute incentive salience to an appetitive cue predicts the propensity attribute motivational salience to an aversive cue. Behavioural Brain Research, 2011, 220, 238-243.

Saunders, B.T. and Robinson, T.E. Individual variation in the motivational properties of cocaine. Neuropsychopharmacology, 2011, 36, 1668-1676.

Lovic, V., Saunders, B.T., Yager, L.M., Robinson, T.E. Rats prone to attribute incentive salience to reward cues are also prone to impulsive action. Behavioural Brain Research, 2011, 223, 255-261.

2010

Flagel, S.B., Robinson, T.E., Clark, J.J., Clinton, S.M., Watson, S.J., Seeman, P., Phillips, P.E., & Akil, H. An animal model of genetic vulnerability to behavioral disinhibition and responsiveness to reward-related cues: implications for addiction. Neuropsychopharmacology, 2010, 35, 388-400.

Saunders, B.T. & Robinson, T.E. A cocaine cue acts as an incentive stimulus in some but not others: implications for addiction. Biological Psychiatry, 2010, 67, 730-736.

Yager, L.M. & Robinson, T.E. Cue-induced reinstatement of food seeking in rats that differ in their propensity to attribute incentive salience to food cues. Behavioural Brain Research, 2010, 214, 30-34.

Wakabayashi, K.T., Weiss, M.J., Pickup, K.N. and Robinson, T.E. Rats markedly escalate their intake and show a persistent susceptibility to reinstatement only when cocaine is injected rapidly. Journal of Neuroscience, 2010, 30, 11346-11355

2009

Berridge, R.C., Robinson, T.E. and Aldridge, W.C. Dissecting components of reward: ‘liking’, ‘wanting’, and learning. Current Opinion in Pharmacology, 2009, 9, 1-9.

Flagel, S.B., Akil, H. and Robinson, T.E. Individual differences in the attribution of incentive salience to reward-related cues: implications for addiction. Neuropharmacology, 2009, 56 (Suppl. 1), 139-148.

Robinson, T.E. and Flagel, S.B. Dissociating the predictive and incentive motivational properties of reward-related cues through the study of individual differences. Biological Psychiatry, 2009, 65, 869-873.

2008

Briand, L.A., Flagel, S.B., Seeman, P., and Robinson, T.E. Cocaine self-administration produces a persistent increase in dopamine D2High receptors. European Neuropsychopharmacology, 2008, 18, 551-556.

Briand, L.A., Flagel, S.B., Watson, S.M., Akil, H., Sarter, M. and Robinson, T.E. Persistent alterations in cognitive function and dopamine-related gene expression following extended (but not limited) access to self-administered cocaine. Neuropsychopharmacology, 2008, 33, 2969-2980.

Briand, L.A., Gross, J.P. and Robinson, T.E. Impaired object recognition following prolonged withdrawal from extended access cocaine self-administration. Neuroscience, 2008, 155, 1-6.briand_2008_neuroscience

Crombag, H.C., Ferrario, C., and Robinson, T.E. The rate of intravenous cocaine or amphetamine delivery: influence on drug-taking and drug-seeking behavior in rats. Pharmacology, Biochemistry & Behavior, 2008, 90, 797-804.

Flagel, S.B., Watson, S.M., Akil, H. and Robinson, T.E. Individual differences in the attribution of incentive salience to a reward-related cue: influence on cocaine sensitization. Behavioural Brain Research, 2008, 186, 48-56.

Robinson, T.E. and Berridge, R.C. The incentive-sensitization theory of addiction: some current issues. Philosophical Transactions of the Royal Society B: Biological Sciences, 2008, 363, 3137-3146.

Uslaner, J.M., Dell’Orco, J.M., Pevzner, A. and Robinson, T.E. The influence of subthalamic nucleus lesions on sign-tracking to stimuli paired with food and drug rewards: facilitation of incentive salience attribution? Neuropsychopharmacology, 2008, 33, 2352-2361.

2007

Flagel, S.B., Watson, S.M., Robinson, T.E. and Akil, H. Individual differences in the propensity to approach signals vs. goals promote different adaptations in the dopamine system. Psychopharmacology, 2007, 191, 599-607.

Jedynak, J.P., Uslaner, J.M., Esteban, J.A. and Robinson, T.E. Methamphetamine-induced structural plasticity in the dorsal striatum. European Journal of Neuroscience, 2007, 25, 847-853.

Ferrario, C.R. and Robinson, T.E. Amphetamine pretreatment accelerates the subsequent escalation of cocaine self-administration behavior. European Neuropsychopharmacology, 2007, 17, 352-357.

2006

Ferguson, S.M., Fasano, S., Yang, P., Brambilla, R. and Robinson, T.E. Knockout of ERK1 enhances cocaine-evoked immediate early gene expression and behavioral plasticity. Neuropsychopharmacology, 2006, 31, 2660-2668.

Jackson, L.R., Robinson, T.E. and Becker, J.B. Sex differences and hormonal influences on acquisition of cocaine self-administration in rats. Neuropsychopharmacology, 2006, 31, 129-138.

Venton, B.J., Robinson, T.E. and Kennedy, R.T. Transient changes in nucleus accumbens amino acid concentrations correlate with individual responsivity to the predator fox odor 2,5-dihydro-2,4,5-trimethylthiazoline. Journal of Neurochemistry, 2006, 96, 236-246.

Venton, B.J., Robinson, T.E. Kennedy, R.T. and Maren, S. Dynamic amino acid increases in the basolateral amygdala during acquisition and expression of conditioned fear. European Journal of Neuroscience, 2006, 23, 3391-3398.

Uslaner, J.M., Acerbo, M.J., Jones, S.A. and Robinson, T.E. The attribution of incentive salience to a stimulus that signals an intravenous injection of cocaine. Behavioural Brain Research, 2006, 169, 320-324.

Uslaner, J.M. and Robinson, T.E. Subthalamic nucleus lesions increase impulsive action and decrease impulsive choice – mediation by enhanced incentive motivation? European Journal of Neuroscience, 2006, 24, 2345-2354.

2005

Crombag, H.S., Gorny, G., Li, Y., Kolb, B. and Robinson, T.E. Opposite effects of amphetamine self-administration experience on dendritic spines in the medial and orbital prefrontal cortex. Cerebral Cortex, 2005, 15, 341-348.

Samaha, A., Yau, W., Yang, P. and Robinson, T.E. Rapid delivery of nicotine promotes behavioral sensitization and alters its neurobiological impact. Biological Psychiatry, 2005, 57, 351-360.

Samaha, N. and Robinson, T.E. Why does the rapid delivery of drugs to the brain promote addiction? Trends in Pharmacological Sciences, 2005, 28, 82-87.

Ferrario, C., Gorny, G., Crombag, H., Kolb, B. and Robinson, T.E. Neural and behavioral plasticity associated with the transition from controlled to escalated cocaine use. Biological Psychiatry, 2005, 58, 751-759.

Uslaner, J., Yang, P., Robinson, T.E. Subthalamic nucleus lesions enhance the psychomotor-activating, incentive motivational, and neurobiological effects of cocaine. The Journal of Neuroscience, 2005, 14, 8407-8414.

2004

Li, Y., Acerbo, M.J. and Robinson, T.E. The induction of behavioral sensitization is associated with cocaine-induced structural plasticity in the core (but not shell) of the nucleus accumbens. European Journal of Neuroscience, 2004, 20, 1647-1654.

Robinson, T.E. and Kolb, B. Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology, 2004, 47, 33-46.

Samaha, A-N., Mallet, N., Ferguson, S.M., Gonon, F. and Robinson, T.E. The rate of cocaine administration alters gene regulation and behavioural plasticity: implications for addiction. Journal of Neuroscience, 2004, 24, 6362-6370.

Ferguson, S.M., Thomas, M.J. and Robinson, T.E. Morphine-induced c-fos mRNA expression in striatofugal circuits: modulation by dose, environmental context and drug history. Neuropsychopharmacology 2004, 29, 1664-1667.

2003

Kolb, B., Gorny, G., Li, Y., Samaha, A-N. and Robinson, T.E. Amphetamine or cocaine limits the ability of later experience to promote structural plasticity in the neocortex and nucleus accumbens. Proceedings of the National Academy of Sciences (USA), 2003, 100, 10523-10528.

Berridge, K.C. and Robinson, T.E. Parsing reward. Trends in Neurosciences, 2003, 26, 507-513.

Uslaner, J.M., Crombag, H.S., Ferguson S.M. and Robinson, T.E. Cocaine-induced psychomotor activity is associated with its ability to induce c-fos mRNA expression in the subthalamic nucleus: effects of dose and repeated treatment. European Journal of Neuroscience, 2003, 17, 2180-2186.

Uslaner, J., Norton, C.S., Watson, S.E., Akil, H. and Robinson, T.E. Amphetamine-induced c-fos mRNA expression in the caudate-putamen and subthalamic nucleus: interactions between dose, environment and neuronal phenotype. Journal of Neurochemistry, 2003, 85, 105-114.

Ferguson, S.M., Norton, C., Watson, S.E., Akil, H. and Robinson, T.E. Amphetamine-evoked c-fos mRNA expression in the caudate-putamen: the effects of DA and NMDA receptor antagonists vary as a function of neuronal phenotype and environmental context. Journal of Neurochemistry, 2003, 86, 33-44.

Li, Y., Kolb, B. and Robinson, T.E. The location of persistent amphetamine-induced changes in the density of dendritic spines on medium spiny neurons in the nucleus accumbens and caudate-putamen. Neuropsychopharmacology, 2003, 28, 1082-1085.

Robinson, T.E. and Berridge, R.C. Addiction. Annual Review of Psychology. 2003, 54, 25-53.

2002

Samaha, A-N, Li ,Y. and Robinson, T.E. The rate of intravenous cocaine administration determines susceptibility to sensitization. Journal of Neuroscience, 2002, 22, 3244-3250.

Robinson, T.E., Gorny, G., Savage, V.R. and Kolb, B. Widespread but regionally-specific effects of experimenter- versus self-administered morphine on dendritic spines in the nucleus accumbens, hippocampus and neocortex of adult rats. Synapse, 2002, 46, 271-279.

Anagnostaras, S.G., Schallert, T. and Robinson, T.E. Memory process governing amphetamine-induced psychomotor sensitization. Neuropsychopharmacology, 2002, 26, 703-715.

2001

Uslaner, J., Badiani, A., Norton, C., Day, H.E.W., Watson, S.E., Akil, H. and Robinson, T.E. Amphetamine and cocaine induce different patterns of c-fos mRNA expression in the striatum and subthalamic nucleus depending on environmental context. European Journal of Neuroscience, 2001, 13, 1977-1983.

Robinson, T.E., Gorny, G., Mitton, E. and Kolb, B. Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex. Synapse, 2001, 39, 257-266.

1990-2000

Robinson, T.E. and Berridge, K.C. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Research Reviews, 1993, 18, 247-291.

Badiani, A., Oates, M., Day, H.E.W., Watson, S.E., Akil, H. and Robinson, T.E. Amphetamine-induced behavior, dopamine release and c-fos mRNA expression: modulation by environmental novelty. Journal of Neuroscience, 1998, 18, 10579-10593.

Robinson, T.E. and Kolb, B. Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine. European Journal of Neuroscience, 1999, 11, 1598-1604.