The Michigan Genomics Initiative (MGI) is a collaborative research effort among physicians, researchers, and patients at the University of Michigan (U-M) with the goal of combining patient electronic health record (EHR) data with corresponding genetic data to gain novel biomedical insights.
The MGI study team processes genetic data for all genotyped study participants at a given time and makes these data available with the release of a “Data Freeze”. To date, MGI has released 6 Data Freezes.
| Data Freeze # | # Participants | Release Date | Storage Location* |
|---|---|---|---|
| 1 | 35,065 | February 2017 | Data Den |
| 2 | 47,513 | September 2018 | Data Den |
| 3 | 56,984 | March 2020 | Data Den |
| 4 | 60,215 | July 2021 | Data Den |
| 5 | 70,439 | November 2022 | Turbo |
| 6 | 80,529 | September 2023 | Turbo |
Current MGI Documentation
MGI Freeze 6 Genome-Wide Genotypes (PDF)
MGI Freeze 6 HLA Inferences (PDF)
MGI Freeze 6 PheWeb (PDF)
MGI Summary Stats Data Use Agreement (PDF)
Targeted Sequencing in the MGI Cohort (PDF)
Whole Exome Sequencing in the MGI Cohort (PDF)
MGI Legacy Documentation
MGI Freeze 5 Star Allele Inferences (PDF)
MGI Freeze 5 Polygenic Scores (PDF)
MGI Freeze 5 Genome-Wide Genotypes (PDF)
MGI Freeze 4 HLA Inferences Tech Notes v1.0
MGI Freeze 4 Genome-wide Genotypes Tech Notes v1.0
MGI Freeze 4 Local Ancestry Inferences Tech Notes v 1.0
MGI Freeze 4 Star Allele Inferences Tech Notes v1.0
MGI Freeze 3 HLA Inferences Technical Notes v1.0
MGI Freeze 3 Star Allele Inferences Tech Notes v1.0
MGI Freeze 3 Genome-wide Genotypes Tech Notes v1.1
MGI Freeze 3 Genome-wide Genotypes Tech Notes v1.2
* MGI implements a policy to move legacy Freezes to long term archive storage as new Freezes become available. Freeze N-2 will retire one month after the release of new Freeze N. Historically Freezes release at a cadence of ~1 year, meaning any given Freeze will “live” in the central directory for ~2 years before moving to archive. Contact phdatahelp@umich.edu with questions.
