Our latest research article is online at PNAS! We used native IM-MS & CIU to study PMP22, a membrane protein involved in Charcot-Marie-Tooth and Dejerine-Sottas Disease. Collaboration with Ohi lab (@Mel_Ohi_lab) & the Sanders lab (@VICB_Vanderbilt) Journal Article: Click Here UMICH News Article: Click Here
A multi-disciplinary approach was employed to study Spy, a small ATP-independent chaperone that simultaneously acts as a protein foldase and holdase molecule. This work demonstrates the Spy chaperones mechanism is substrate specific and dependent on relative affinity for a proteins intermediate folding states which highlights the central and dynamic role […]
Through an extensive characterization of travelling wave ion mobility (TWIM) calibrations protocols using over 2500 experimental TWIM datasets, and ranging across several molecular classes spanning over 3.5 orders of magnitude in molecular mass, a robust calibration method has been developed that offers high-precision ccs measurements for existing and future TWIM […]
Join us for the 1st UM/Agilent Symposium on Emerging Mass Spectrometry Methods for Protein Characterization hosted virtually over two days by the Ruotolo Lab, Hakansson lab (KristinaHakans2), and Agilent on January 20th and 27th, 2021! To get your free link to the meeting use our symposium’s registration form (Click Here!)
Native MS was used to determine the formation of prenylated FMN (prFMN) adducts via ligand dissociation experiments, presenting the first detailed kinetic analysis of a member of the recently identified and rapidly expanding family of prFMN-dependent decarboxylases. Check it out here!
Congrats to Kristine Parson and Carolina Rojas Ramirez for winning poster presentation awards recently at the Chemistry Departments annual Karle Symposium! Great job to these ladies who participated in the Karle Symposium.
We are excited to announce the recent publication from JACS featuring our recent work in collaboration with the Sanders Lab at Vanderbilt University! “Bicelles Rich in both Sphingolipids and Cholesterol and Their Use in Studies of Membrane Proteins”
Looking for some post-ASMS content. Catch Brandon’s talks at the Water’s 2020 virtual biopharmaceutical symposium June 23rd and his Agilent biopharma seminar June 24th. Details Below: June 23d, 9:00-11:30AM EST: Waters Virtual Mass Spectrometry Symposium – Focus on Biopharmaceuticals. Register Here June 24th, 2:30-4:00PM EST: Agilent Webinar – New Characterization […]
Looking for some post-ASMS content?! Join us at this years annual ion mobility workshop hosted by Agilent Thursday, June 18th, 2020, 11:30 am – 1:00 pm PST. We’ll hear about the exciting developments of ion mobility at Agilent, the state of SLIM ion mobility from MOBILion, and capped off with […]
One aspect of ASMS we look forward to every year is the opportunity to host a reunion and reconnect with our Alumni. Despite our inability to meet in person, and the challenges this new normal has brought to all of our daily lives, it did not affect this Ruotolo group […]