The E. S. George Reserve is located about 25 km northwest of Ann Arbor, Michigan, in the SW corner of Livingston County (approximately 42° 28′ N, -84° 00′ W). It lies within Range 4E (Michigan Meridian), Twp. 1N (Michigan baseline) and covers Section 19 and parts of Sections 25, 29, and 30 of Putnam Twp. and parts of Sections 24 and 25 of Unadilla Twp.

Driving directions from Ann Arbor can be downloaded as a PDF by clicking here.  Driving directions from other locations can be obtained using online mapping utilities.