Collision induced unfolding (CIU), which is a collisional activation method in the gas phase, provides a way of differentiating proteins of similar structure as well as measure the stability of proteins. CIU has been used for a variety of applications such as differentiating binding modes of different ligands, distinguishing isocross-sectional proteins, etc. CIUSuite is a software package that rapidly processes, analyzes, compares, and classifies CIU data.
For more information, please refer to Eschweiler, J. D. et al, Anal. Chem., 2015, 87 (22)
To download the CIUSuite 2 software, please click here.