Overview
Structural biology is ultimately concerned with determining high resolution structures of all the functional macromolecules within living cells and tissues. While structural information can be obtained using a wide array of technologies, conventional methods face significant challenges when applied to dynamic, heterogeneous multi-protein targets. Consequently, there is a need to investigate new approaches that define the subunit stoichiometry, composition, and shape of heterogeneous macromolecular complexes of biological importance. In our group, we are developing ion mobility-mass spectrometry (IM-MS) based techniques to answer important structural questions about these large macromolecular complexes. Our efforts focused in structural characterization of protein complexes fall into three main categories:
- Understanding the structural properties of proteins in the gas-phase
- Using IM-MS measurements to develop structural models of protein complexes
- Developing computational platforms for integrating IM-MS and other datasets into 3D models
- Welcome Addison, Hanyu, and Ryan!
- Congratulations to Iliana!
- Congratulations to Dr. Rojas Ramirez and Dr. Parson!
- Congratulations to Dr. Han!
- New Publication from the Ruotolo Lab Featured in UM News!
Contact
Ruotolo Group
University of Michigan
Department of Chemistry
Room 4550
930 N. University Ave, Ann Arbor, MI 48109-1055
Phone: (+1) 734-763-2443
Fax: (1+) 734-615-3718