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2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993
2024
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223. Chauvier, A., Dandpat, S., Romero, R. and Walter, N.G. (2024) A nascent riboswitch helix orchestrates robust transcriptional regulation through signal integration. Nat. Commun. 15, 3955. Full text with supplement in pdf format.
222. Walter, N.G. (2024) Are non-protein coding RNAs junk or treasure? Bioessays, 2300201. Full text in pdf format.
221. Centola, M., Poppleton, E., Ray, S., Centola, M., Welty, R., Valero, J., Walter, N.G., Šulc, P. and Famulok, M. (2024) A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower. Nat. Nanotech., 19, 226-236. Full text with supplement in pdf format.
220. Chauvier, A. and Walter, N.G. (2024) Regulation of bacterial gene expression by non-coding RNA: it is all about time! Cell Chem. Biol. 31, 71-85. Full text in pdf format.
2023
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219. Gao, G., Sumrall, E.S., Pitchiaya, S., Bitzer, M., Alberti, S. and Walter, N.G. (2023) Biomolecular Condensates in Kidney Physiology and Disease. Nat. Rev. Nephrol. 19, 756-770. Full text in pdf format.
218. Hou, Q., Chatterjee, S., Lund, P.E., Suddala, K.C. and Walter, N.G. (2023) Single-molecule FRET observes opposing effects of urea and TMAO on structurally similar meso- and thermophilic riboswitch RNAs. Nucleic Acids Res. 51, 11345-11357. Full text with supplement in pdf format.
217. Gao, G. and Walter, N.G. (2023) Critical Assessment of Condensate Boundaries in Dual-Color Single Particle Tracking. J. Phys. Chem. B 127, 7694-7707. Full text with supplement in pdf format.
216. Perelman, R.T., Schmidt, A., Khan, U. and Walter, N.G. (2023) Spontaneous Confinement of mRNA Molecules at Biomolecular Condensate Boundaries. Cells 12, 2250. Full text with supplement in pdf format.
215. Chauvier, A., Porta, J.C., Deb, I., Ellinger, E., Meze, K., Frank, A.T., Ohi, M.D. and Walter, N.G. (2023) Structural basis for control of bacterial RNA polymerase pausing by a riboswitch and its ligand. Nat. Struct. Mol. Biol. 30, 902-913. Full text with supplement in pdf format.
214. Ellinger, E., Chauvier, A., Romero, R.A., Liu, Y., Ray, S. and Walter, N.G. (2023) Riboswitches as therapeutic targets: Promise of a new era of antibiotics. Expert Opin. Ther. Targets 27, 433-445. Full text in pdf format.
213. Duran, E., Schmidt, A., Welty, R., Jalihal, A.P., Pitchiaya, S. and Walter, N.G. (2023) Utilizing functional cell-free extracts to dissect ribonucleoprotein complex biology at single-molecule resolution. WIREs RNA, e1787. Full text in pdf format.
212. Pal, N. and Walter, N.G. (2023) Using single molecule FRET to evaluate DNA nanodevices at work. Methods Mol. Biol. 2639, 157-175. Full text in pdf format.
211. Welty, R., Schmidt, A. and Walter, N.G. (2023) Probing transient riboswitch structures via single molecule accessibility analysis. Methods Mol. Biol. 2568, 37-51. Full text in pdf format.
2022
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210. Chatterjee, T., Johnson-Buck, A. and Walter, N.G. (2022) Highly Sensitive Protein Detection by Aptamer-Based Single-Molecule Kinetic Fingerprinting. Biosens. Bioelectron. 216, 114639. Full text with supplement in pdf format.
209. Ray, S., Dandpat, S.S., Chatterjee, S. and Walter, N.G. (2022) Precise tuning of bacterial translation initiation by non-equilibrium 5’-UTR unfolding observed in single mRNAs. Nucleic Acids Res. 50, 8818-8833. Full text with supplement in pdf format.
208. Blanchard, A.T., Li, Z., Duran, E.C., Scull, C.E., Hoff, J.D., Wright, K.R., Pan, V. and Walter, N.G. (2022) Ultra-photostable DNA FluoroCubes: mechanism of photostability and compatibility with FRET and dark quenching. Nano Lett. 22, 6235−6244. Full text with supplement in pdf format. Highlighted in Nature Methods.
207. Li, Z., McNeely, M., Sandford, E., Tewari, M., Johnson-Buck, A. and Walter, N.G. (2022) Attomolar sensitivity in single biomarker counting upon aqueous two-phase surface enrichment. ACS Sensors 7, 1419-1430. Full text with supplement in pdf format.
206. Yadav, R., Widom, J.R., Chauvier, A. and Walter, N.G. (2022) An anionic ligand snap-locks a long-range interaction in a magnesium-folded riboswitch. Nat. Commun. 13, 207. Full text with supplement in pdf format.
205. Mandal, S., Khanna, K., Johnson-Buck, A., and Walter, N.G. (2022) A guide to accelerated direct digital counting of single nucleic acid molecules by FRET-based intramolecular kinetic fingerprinting. Methods 197, 63-73. Full text in pdf format. Highlighted in NCI’s Epidemiology and Genomics Research Program (EGRP)
2021
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204. Chandler, M., Johnson, B., Khisamutdinov, E., Dobrovolskaia, M., Sztuba-Solinska, J., Salem, A., Breyne, K., Chammas, R., Walter, N.G., Contreras, L., Guo, P. and Kirill, A. (2021) The International Society of RNA Nanotechnology and Nanomedicine (ISRNN): The Present and Future of the Burgeoning Field. ACS Nano 15, 16957-16973. Full text in pdf format.
203. Grillo, C., Holford, M. and Walter, N.G. (2021) From flatland to Jupiter: Searching for rules of interaction across biological scales. Integr. Comp. Biol. 61, 2048-2052. Full text with supplement in pdf format.
202. Chauvier, A., Ajmera, P., Yadav, R. and Walter, N.G. (2021) Dynamic competition between a ligand and transcription factor NusA governs riboswitch-mediated transcription regulation. Proc. Natl. Acad. Sci. USA 118, e2109026118. Full text with supplement in pdf format.
201. Khanna, K., Mandal, S., Blanchard, A.T., Tewari, M., Johnson-Buck, A., and Walter, N.G. (2021) Rapid kinetic fingerprinting of single nucleic acid molecules by a FRET-based dynamic nanosensor. Biosens. Biolelectron. 190, 113433. Full text with supplement in pdf format.
200. Chatterjee, S., Chauvier, A., Dandpat, S.S., Artsimovitch, I. and Walter, N.G. (2021) A translational riboswitch coordinates nascent transcription-translation coupling. Proc. Natl. Acad. Sci. USA. 118 e2023426118. Full text with supplement in pdf format. Highlighted as a Commentary in Proc. Natl. Acad. Sci.
199. Jiang, S., Pal, N., Hong, F., Fahmi, N.E., Hu, H., Vrbanac, M., Yan, H., Walter, N.G. and Liu, Y. (2021) Regulating DNA Self-assembly Dynamics with Controlled Nucleation. ACS Nano 15, 5384-5396. Full text in pdf format.
198. Ray, S., Pal, N. and Walter, N.G. (2021) A bacterial resolvase first exploits, then constrain intrinsic dynamics of the Holliday junction to direct recombination. Nucleic Acids Res. 49, 2803-2815. Full text in pdf format.
197. Duran, E.C. and Walter, N.G. (2021) Sisyphus observed: Unraveling the high ATP usage of an RNA chaperone. J. Biol. Chem. 296, 100265. Full text in pdf format.
196. Mandal, S., Li, Z., Chatterjee, T., Khanna, K., Montoya, K., Dai, L., Petersen, C., Li, L., Tewari, M., Johnson-Buck, A., and Walter, N.G. (2021) Direct kinetic fingerprinting for high-accuracy single-molecule counting of diverse disease biomarkers. Acc. Chem. Res. 54, 388-402. Full text in pdf format.
195. Scull, C.E., Dandpat, S.S., Romero, R.A., and Walter, N.G. (2021) Transcriptional riboswitches integrate timescales for bacterial gene expression control. Front. Mol. Biosci. 7, 607158. Full text in pdf format.
194. Jalihal, A.P., Schmidt, A., Gao, G., Little, S.R., Pitchiaya, S. and Walter, N.G. (2021) Hyperosmotic phase separation: Condensates beyond inclusions, granules and organelles. J. Biol. Chem. 296, 100044. Full text in pdf format.
2020
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193. Li, J., Zhang, L., Johnson-Buck, A. and Walter, N.G. (2020) Automatic classification and segmentation of single-molecule fluorescence trajectories with deep learning. Nat. Commun. 11, 5833. Full text with supplement in pdf format.
192. Chatterjee, T., Knappik, A., Sandford, E., Tewari, M., Strong, W.B., Thrush, E.P., Oh, K.J., Liu, N., Walter, N.G. and Johnson-Buck, A. (2020) Direct kinetic fingerprinting and digital counting of single protein molecules. Proc. Natl. Acad. Sci. USA 117, 22815-22822.Full text with supplement in pdf format.
191. Jalihal, A.P., Pitchiaya, S., Xiao, L., Bawa, P., Jiang, X., Bedi, K., Parolia, A., Cieslik, M., Ljungman, M., Chinnaiyan, A.M., and Walter, N.G. (2020) Multivalent proteins rapidly and reversibly phase-separate upon osmotic cell volume change. Mol. Cell 79, 978-990. Full text with supplement in pdf format. Highlighted as a Preview in Molecular Cell.
190. Paez-Colasante, X., Figueroa-Romero, C., Rumora, A.E., Hur, J., Mendelson, F.E., Hayes, J.M., Backus, C., Taubman, G.F., Heinicke, L., Walter, N.G., Barmada, S.J., Sakowski, S.A. and Feldman, E.L. (2020) Cytoplasmic TDP43 binds microRNAs: New disease targets in Amyotrophic Lateral Sclerosis. Frontiers Cell. Neurosci. 14, 117. Full text with supplement in pdf format.
189. Lund, P.E., Chatterjee, S., Daher, M., and Walter, N.G. (2020) Protein unties the pseudoknot: S1-mediated unfolding of RNA higher order structure. Nucleic Acids Res. 48, 2107-2125. Full text with supplement in pdf format.
188. Schmidt, A., Gao, G., Little, S.R., Jalihal, A.P., and Walter, N.G. (2020) Following the messenger: Recent innovations in live cell single molecule fluorescence imaging. WIREs RNA, e1587. Full text in pdf format.
187. Chatterjee, T., Li, Z., Khanna, K., Montoya, K., Tewari, M., Walter, N.G. and Johnson-Buck, A. (2020) Ultraspecific analyte detection by direct kinetic fingerprinting of single molecules. Trends Anal. Chem. 123, 115764. Full text in pdf format.
2019
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186. Widom, J.R., Rai, V., Rohlman, C.E. and Walter, N.G. (2019) Versatile transcription control based on reversible dCas9 binding. RNA 25, 1457-1469. Full text in pdf format.
185. Suddala, K.C., Price, I.R., Dandpat, S., Janeček, M., Kührová, P., Šponer, J., Banáš, P., Ke, A. and Walter, N.G. (2019) Local-to-global signal transduction at the core of the Mn2+ sensing riboswitch. Nat. Commun. 10, 4304. Full text with supplement in pdf format.
184. Ray, S., Chauvier, A. and Walter, N.G. (2019) Kinetics coming into focus: single-molecule microscopy of riboswitch dynamics. RNA Biol. 16, 1077-1085. Full text in pdf format.
183. Walter, N.G. (2019) Biological Pathway Specificity in the Cell – Does Molecular Diversity Matter? BioEssays 41, 1800244. Full text in pdf format. Video Abstract found at https://youtu.be/T19X_zYaBzg.
182. Chauvier, A., Cabello-Villegas, J., and Walter, N.G. (2019) Probing RNA structure and interaction dynamics at the single molecule level. Methods 162-163, 3-11. Full text in pdf format.
181. Pitchiaya, S., Mourao, M.D.A., Jalihal, J., Xiao, L., Jiang, X., Chinnaiyan, A.M., Schnell, S. and Walter, N.G. (2019) Dynamic recruitment of single RNAs to processing bodies depends on RNA functionality. Mol. Cell 74, 521-533. Full text (with supplement) in pdf format. Highlighted as a Preview in Molecular Cell.
180. Prakash, V., Tsekouras, K., Venkatachalapathy, M., Heinicke, L.A., Pressé, S., Walter, N.G. and Krishnan. Y. (2019) Quantitative maps of endosomal DNA processing by single molecule counting. Angew. Chem. Int. Ed. 58, 3073-3076. Full text (with supplement) in pdf format.
179. Weng, R., Lou, S., Li, L., Zhang, Y., Qiu, J., Su, X., Qian, Y. and Walter, N.G. (2019) Single-molecule kinetic fingerprinting for the ultrasensitive detection of small molecules with aptasensors. Anal. Chem. 91, 1424-1431. Full text (with supplement) in pdf format.
178. Johnson-Buck, A., Li, J., Tewari, M. and Walter, N.G. (2019) A guide to nucleic acid detection by single-molecule kinetic fingerprinting. Methods 153, 3-12. Full text in pdf format.
177. Walter, N.G. (2019) Convergence of science and technology: fluorescent resolution of single RNA molecules. Methods 153, 1-2. Full text in pdf format.
176. Jalihal, A.P., Lund, P.E. and Walter, N.G. (2019) Coming together: RNAs and proteins assemble under the single molecule fluorescence microscope. In The RNA Worlds: New Tools for Deep Exploration, pp. 451-470 (Ed. T.R. Cech, J.A. Steitz & J.F. Atkins), Cold Spring Harb. Perspect. Biol. 11, a032441. Full text in pdf format.
2018
175. Widom, J.R.. Nedialkov, Y.A., Rai, V., Hayes, R.L., Brooks, C.L., Artsimovitch, I. and Walter, N.G. (2018) Ligand-modulated cross-coupling between riboswitch folding and transcriptional pausing. Mol. Cell 72, 541-552. Full text (with supplement) in pdf format.
174. Hayward, S.L., Lund, P.E., Kang, Q., Johnson-Buck, A., Tewari, M., and Walter, N.G. (2018) Ultraspecific and amplification-free quantification of mutant DNA by single-molecule kinetic fingerprinting. J. Am. Chem. Soc. 140, p. 11755-11762. Full text (with supplement) in pdf format.
173. Li, J., Johnson-Buck, A., Yang, Y.R., Shih, W.M., Yan, H. and Walter, N.G. (2018) Exploring the speed limit of toehold exchange with a cartwheeling DNA acrobat. Nat. Nanotechnol. 13, 723-729. Full text (with supplement) in pdf format.
172. Yang, G., Liu, C., Chen, S.-H., Kassab, M., Hoff, J.D., Walter, N.G. and Yu, X. (2018) Super-resolution imaging identifies PARP1 and the Ku complex acting as DNA double-strand break sensors. Nucleic Acids Res. 46, 3446-3457. Full text (with supplement) in pdf format.
171. Valero, J., Pal, N., Dhakal, S., Walter, N.G. and Famulok, M. (2018) A bio-hybrid DNA rotor/stator nanoengine that moves along predefined tracks. Nat. Nanotechnol. 13, 496-503. Full text (with supplement) in pdf format.
170. Suddala, K.C., Cabello-Villegas, J., Michnicka, M., Marshall, C., Nikonowicz, E.P. and Walter, N.G. (2018) Hierarchical mechanism of amino acid sensing by the T-box riboswitch. Nat. Commun. 9, 1896. Full text (with supplement) in pdf format.
169. Walter, N.G. and Maquat, L.E. (2018) Introduction to “RNA: From Single Molecules to Medicine”. Chem. Rev. 118, 4117-4119. Full text in pdf format.
168. Ray, S., Widom, J.R. and Walter, N.G. (2018) Life under the microscope: Single-molecule fluorescence highlights the RNA World. Chem. Rev. 118, 4120-4155. Full text in pdf format.
167. Sponer, J., Bussi, G., Krepl, M., Banáš, P., Bottaro, S., Cunha, R.A., Gil-Ley, A., Pinamonti, G., Poblete, S., Jurecka, P., Walter, N.G. and Otyepka, M. (2018) RNA structural dynamics as captured by molecular simulations: a comprehensive overview. Chem. Rev. 118, 4177-4338. Full text in pdf format.
166. Michelini, F., Jalihal, A., Francia, S., Meers, C., Neeb, Z. T., Rossiello, F., Gioia, U., Aguado, J., Luke, B., Biamonti, G., Nowacki, M., Storici, F., Carninci, P., Walter, N.G. and d’Adda di Fagagna, F. (2018) From “cellular” RNA to “smart” RNA: multiple roles of RNA in genome stability. Chem. Rev. 118, 4365-4403. Full text in pdf format.
165. Daher, M., Widom, J.R., Tay, W. and Walter, N.G. (2018) Soft interactions with model crowders and non-canonical interactions with cellular proteins stabilize RNA folding. J. Mol. Biol. 430, 509-523. Full text (with supplement) in pdf format.
2017
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164. Michelini, F., Pitchiaya, S., Vitelli, V., Sharma, S., Gioia, U., Pessina, F., Cabrini, M., Wang, Y., Capozzo, I., Iannelli, F., Matti, V., Francia, S., Shivashankar, G.V., Walter, N.G. and d’Adda di Fagagna, F. (2017) Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks. Nat. Cell Biol. 19, 1400-1411. Full text (with supplement) in pdf format. Highlighted in Nature Cell Biology News and Views
163. Daher, M., Li, X., Mustoe, A.M., Morriss-Andrews, A.,Brooks III, C.L. and Walter, N.G. (2017) Tuning RNA folding and function through rational design of junction topology. Nucleic Acids Res. 45, 9706-9715. Full text (with supplement) in pdf format.
162. Mieritz, D., Li, X., Volosin, A., Liu, M.,Yan, H., Walter, N.G. and Seo, D. (2017) Tracking single DNA nanodevices in hierarchically meso-macroporous antimony-doped tin oxide demonstrates finite confinement. Langmuir 33, 6410-6418. Full text (with supplement) in pdf format.
161. Custer, T.C. and Walter, N.G. (2017) In vitro labeling strategies for in cellulo fluorescence microscopy of single ribonucleoprotein machines. Protein Sci. 26, 1363-1379. Full text (with supplement) in pdf format.
160. Pitchiaya, S., Heinicke, L.A., Park, J.A., Cameron, E.L., Walter, N.G. (2017) Resolving subcellular miRNA trafficking and turnover at single-molecule resolution. Cell Rep. 19, 630-642. Full text (with supplement) in pdf format.
2016
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159. Tsekouras, K., Custer, T.C., Jashnsaz, H., Walter, N.G. and Pressé, S. (2016) A novel method to accurately locate and count large numbers of steps by photobleaching. Mol. Biol. Cell 27, 3601-3615. Full text in pdf format.
158. Rohlman, C.E., Blanco, M.R. and Walter N.G. (2016) Putting Humpty–Dumpty together: clustering the functional dynamics of single biomolecular machines such as the spliceosome. Methods Enzymol. 581, 257-283. Full text in pdf format.
157. Suresh, M.V., Thomas, B., Machado-Aranda, D., Dolgachev, V.A., Ramakrishnan, S.K., Talarico, N., Cavassani, K., Sherman, M.A., Hemmila, M.R., Kunkel, S.L., Walter, N.G., Hogaboam, C.M. and Raghavendran, K. (2016) Double-stranded RNA interacts with toll-like receptor 3 in driving the acute inflammatory response following lung contusion. Crit. Care Med. 44, e1054-e1066. Full text in pdf format.
156. Fu, J., Yang, Y.R., Dhakal, S., Zhao, Z., Liu, M., Zhang, T., Walter, N.G. and Yan, H. (2016) Assembly of multienzyme complexes on DNA nanostructures. Nat. Protoc. 11, 2243-2273. Full text in pdf format.
155. Walter, N.G. (2016) Introductory Editorial: Special section on single-molecule and super-resolution microscopy of biopolymers. Biopolymers 105, 669. Full text in pdf format.
154. Semlow, D.R., Blanco, M.R., Walter, N.G. and Staley, J. (2016) Spliceosomal DEAH-box ATPases remodel pre-mRNA to activate alternative splice sites. Cell 164, 985-998. Full text in pdf format.
153. Zhao, Z., Fu, J., Dhakal, S., Johnson-Buck, A., Liu, M., Zhang, T., Woodbury, N.W., Liu, Y., Walter, N.G. and Yan, H. (2016) Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion. Nat. Commun. 7, 1-8. Full text in pdf format. Supplementary Information in pdf format.
152. Shankar, S., Pitchiaya, S., Malik, R., Kothari, V., Hosono, Y., Yocum, A.K., Gundlapalli, H., White, Y., Firestone, A., Cao, X., Dhanasekaran, S.M., Stuckey, J.A., Bollag, G., Shannon, K., Walter, N.G., Kumar-Sinha, C. and Chinnaiyan, A.M. (2016) KRAS engages AGO2 to enhance cellular transformation. Cell Rep. 14, 1448-1461. Full text and Supplementary Information in pdf format.
151. Dhakal, S., Adendorff, M.R., Liu, M., Yan, H., Bathe, M. and Walter, N.G. (2016) Rational design of DNA-actuated enzyme nanoreactors guided by single molecule analysis. Nanoscale 8, 3125-3137. Full text in pdf format. Supplementary Information in pdf format. Please click here to access supplementary movies.
150. Rinaldi, A.J., Lund, P.E., Blanco, M.R. and Walter, N.G. (2016) The Shine-Dalgarno sequence of riboswitch-regulated single mRNAs shows ligand-dependent accessibility bursts. Nat. Commun. 7, 8976. Full text in pdf format. Supplementary Information in pdf format.
2015
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149. Suddala, K.C., Wang, J., Hou, Q., and Walter, N.G. (2015) Mg2+ shifts ligand-mediated folding of a riboswitch from induced-fit to conformational selection. J. Am. Chem. Soc. 137, p. 14075-14083. Full text in pdf format. Supplementary Information in pdf format. See Spotlights on recent JACS publications.
148. Blanco, M.R., Martin, J.S., Kahlscheuer, M.L., Krishnan, R., Abelson, J., Laederach, A. and Walter, N.G. (2015) Single molecule cluster analysis dissects splicing pathway conformational dynamics. Nature Methods 12, p. 1077-1086. Full text in pdf format. Supplementary Information in pdf format.
147. Mallik, L., Dhakal, S., Nichols, J., Mahoney, J., Dosey, A.M., Jiang, S., Sunahara, R.K., Skiniotis, G. and Walter, N.G. (2015) Electron microscopic visualization of protein assemblies on flattened DNA origami. ACS Nano 9, p. 7133-7141. Full text in pdf format. Supplementary Information in pdf format.
146. Dubecký, M., Walter N.G., Šponer, J., Otyepka, M. and Banáš, P. (2015) Chemical feasibility of the general base/acid mechanism of glmS ribozyme self-cleavage. Biopolymers 103, p. 550-562. Full text in pdf format. Supplementary Information in pdf format.
145. Johnson-Buck, A., Su, X., Giraldez, M.D., Zhao, M., Tewari, M. and Walter, N.G. (2015) Kinetic fingerprinting to identify and count single nucleic acids. Nat. Biotechnol. 33, p. 730-732. Full text in pdf format. Supplementary Information in pdf format.
144. Liberman, J.A., Suddala, K.C., Aytenfisu, A.H., Chan, D., Belashov, I.A., Salim, M., Mathews, D.H., Spitale, R.C., Walter, N.G. and Wedekind, J.E. (2015) Structural analysis of a class III preQ1 riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics. Proc. Natl. Acad. Sci. USA 112, p. E3485-E3494. Full text and Supplementary Information in pdf format.
143. Kahlscheuer, M.L., Widom, J.R. and Walter, N.G. (2015) Single-Molecule Pull-down FRET (SiMPull-FRET) to dissect the mechanisms of biomolecular machines. Methods Enzymol. 558, p. 539-570. Full text in pdf format.
142. Mlynsky, V., Kuhrova, P., Zgarbova, M., Jurecka, P., Walter N.G., Otyepka, M., Sponer, J. and Banas, P. (2015). Reactive conformation of the active site in the hairpin ribozyme achieved by molecular dynamics simulations with epsilon/zeta force field reparameterizations. J. Phys. Chem. B 119, p. 4220-4229. Full text in pdf format.
141. Walter, N.G. (2015). Going viral: riding the RNA wave to discovery. RNA 21, p. 756-757. Full text in pdf format.
140. Bartke, R.M., Cameron, E.L., Cristie-David, A.S., Custer, T.C., Denies, M.S., Daher, M., Dhakal, S., Ghosh, S., Heinicke, L.A., Hoff, J.D., Hou, Q., Kahlscheuer, M.L., Karslake, J., Krieger, A.G., Li, J., Li, X., Lund, P.E., Vo, N.N., Park, J., Pitchiaya, S., Rai, V., Smith, D.J., Suddala, K.C., Wang, J., Widom, J.R. and Walter, N.G. (2015). Meeting report: SMART timing-principles of single molecule techniques course at the University of Michigan 2014. Biopolymers 103, p. 296-302. Full text in pdf format.
139. Sripathi, K.N., Banas, P., Reblova, K., Sponer, J., Otyepka, M., and Walter, N.G. (2015). Wobble pairs of the HDV ribozyme play specific roles in stabilization of active site dynamics. Phys. Chem. Chem. Phys. 17, p. 5887-5900. Full text in pdf format.
138. Nyati, S., Schinske-Sebolt, K., Pitchiaya, S., Chekhovskiy, K., Chator, A., Chaudhry, N., Dosch, J., Van Dort, M.E., Varambally, S., Kumar-Sinha, C., Nyati, M.K., Ray, D., Walter, N.G., Yu, H., Ross, B.D. and Rehemtulla, A. (2015). The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-b signaling. Sci. Signal. 8, ra1, p. 1-11. Full text in pdf format. Supplementary Information in pdf format.
137. Mlynsky, V., Walter, N.G., Sponer, J., Otyepka, M. and Banas, P. (2015). The role of an active site Mg2+ in HDV ribozyme self-cleavage: insights from QM/MM calculations. Phys. Chem. Chem. Phys. 17, p. 670-679. Full text in pdf format.
136. Rinaldi, A.J., Suddala, K.C. and Walter, N.G. (2015). Native purification and labeling of RNA for single molecule fluorescence studies. Methods Mol. Biol. 1240, p. 63-95. Full text in pdf format.
2014
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135. Pitchiaya, S., Androsavich, J.R. and Walter, N.G. (2014). Super-accuracy and super-resolution fluorescence microscopy based on single molecule detection. In Imaging Life: Chapter 9, pp. 228-259 (G. C. Howard, W. E. Brown, and M. Auer, eds.), Oxford University Press, New York. Full text in pdf format.
134. Suddala, K.C. and Walter, N.G. (2014). Riboswitch structure and dynamics by smFRET microscopy. Methods Enzymol. 549, p. 343-373. Full text in pdf format.
133. Widom, J.R., Dhakal, S., Heinicke, L.A. and Walter, N.G. (2014). Single-molecule tools for enzymology, structural biology, systems biology and nanotechnology: an update. Arch. Toxicol. 88, p. 1965-1985. Full text in pdf format.
132. Fu, J., Yang, Y.R., Johnson-Buck, A., Liu, M., Liu, Y., Walter, N.G., Woodbury, N.W. and Yan, H. (2014). Multi-enzyme complexes on DNA scaffolds capable of substrate channelling with an artificial swinging arm. Nat. Nanotechnol. 9, p. 531-536. Full text in pdf format. Supplementary Information in pdf format.
131. Johnson-Buck, A., Jiang, S., Yan, H. and Walter, N.G. (2014). DNA-cholesterol barges as programmable membrane-exploring agents. ACS Nano 8, p. 5641-5649. Full text in pdf format. Supplementary Information in pdf format.
130. Sripathi, K.N., Tay, W.W., Banas, P., Otyepka, M., Sponer, J. and Walter, N.G. (2014). Disparate HDV ribozyme crystal structures represent intermediates on a rugged free-energy landscape. RNA 20, p. 1112-1128. pdf
129. Johnson-Buck, A. and Walter, N.G. (2014). Discovering anomalous hybridization kinetics on DNA nanostructures using single-molecule fluorescence microscopy. Methods 67, p. 177–184. pdf
128. Harris, D.A., Todd, G.C. and Walter, N.G. (2014). Terbium(III) footprinting as a probe of RNA structure and metal binding sites. In Handbook of RNA Biochemistry: Second, Completely Revised and Enlarged Edition, Part II, pp. 255-268 (R.K. Hartmann, A. Bindereif, A. Schon, and E. Westhof, eds.), Wiley-VCH Verlag, Weinheim. pdf
127. Walter, N.G. and Bustamante, C.J. (2014). Introduction to single molecule imaging and mechanics: seeing and touching molecules one at a time. Chem. Rev. 114, p. 3069−3071. pdf
126. Pitchiaya, S., Heinicke, L.A., Custer, T.C. and Walter, N.G. (2014). Single molecule fluorescence approaches shed light on intracellular RNAs. Chem. Rev. 114, p. 3224-3265. pdf
125. Grima, R., Walter, N.G. and Schnell, S. (2014). Single-molecule enzymology a la Michaelis-Menten. FEBS Journal. 281, p. 518-530. pdf
2013
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124. Suddala, K.C., Rinaldi, A.J., Feng, J., Mustoe, A.M., Eichhorn, C.D., Liberman, J.A., Wedekind, J.E., Al-Hashimi, H.M., Brooks III, C.L. and Walter, N.G. (2013). Single transcriptional and translational preQ1 riboswitches adopt similar pre-folded ensembles that follow distinct folding pathways into the same ligand-bound structure. Nucleic Acids Res. 41, p. 10462-10475. pdf. Supplementary Information
123. Krishnan, R., Blanco, M.R., Kahlscheuer, M.L., Abelson, J., Guthrie, C. and Walter, N.G. (2013). Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing. Nat. Struct. Mol. Biol. 20, p. 1450-1459. pdf. Supplementary Information
122. Pitchiaya, S., Krishnan, V., Custer, T.C. and Walter, N.G. (2013). Dissecting non-coding RNA mechanisms in cellulo by Single-molecule High-Resolution Localization and Counting. Methods. 63, p. 188-199. pdf
121. Walter, N.G. (2013). The bright future of (non-coding) RNAs: methods light the way. Methods. 63, p. 93-94. pdf
120. Breslauer, K.J., Case, D.A., Walter, N.G. and Woodson, S.A. (2013). Biopolymers celebrates 50 years of nucleic acids research. Biopolymers. 99, p. 909. PDF
119. Ma, J., Liu, Z., Michelotti, N., Pitchiaya, S., Veerapaneni, R., Androsavich, J.R., Walter, N.G. and Yang, W. (2013). High-resolution three-dimensional mapping of mRNA export through the nuclear pore. Nat. Commun. 4: 2414, doi: 10.1038/ncomms3414. pdf
118. Johnson-Buck, A., Nangreave, J., Jiang, S., Yan, H. and Walter, N.G. (2013). Multifactorial modulation of binding and dissociation kinetics on two-dimensional DNA nanostructures. Nano Lett. 13, p. 2754-2759. pdf. Supplementary Information
117. Todd, G.C. and Walter, N.G. (2013). Secondary structure of bacteriophage T4 gene 60 mRNA: implications for translational bypassing. RNA. 19, p. 685-700. pdf
116. Cline, E.N., Li, M., Choi, S.K., Herbstman, J.F., Kaul, N., Meyhofer, E., Skiniotis, G., Baker, J.R., Larson, R.G. and Walter, N.G. (2013). Paclitaxel-conjugated PAMAM dendrimers adversely affect microtubule structure through two independent modes of action. Biomacromolecules. 14, p. 654-664. pdf. Supplementary Information
115. Johnson-Buck, A., Nangreave, J., Kim, D., Bathe, M., Yan, H., and Walter, N.G. (2013) Super-resolution fingerprinting detects chemical reactions and idiosyncrasies of single DNA pegboards. Nano Lett. 13, p. 728-733. pdf. Supplementary Information
2012
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114. Sponer, J., Otyepka, M., Banas, P., Reblova, K. and Walter N.G. (2012). Molecular dynamics simulations of RNA molecules. Chapter 6 in Innovations in Biomolecular Modeling and Simulations, Vol. 2 (Ed. T. Schlick) RSC. PDF
113. Blanco, M.R., Johnson-Buck, A.E. and Walter, N.G. (2012). Hidden Markov modeling. In G.C.K. Roberts (ed.), Encyclopedia of Biophysics, pp. 971-975 (Ed. G. Roberts), Springer. PDF
112. Johnson-Buck, A.E., Blanco, M.R. and Walter, N.G. (2012). Single-molecule fluorescence resonance energy transfer. In G.C.K. Roberts (ed.), Encyclopedia of Biophysics, pp. 2329-2335 (Ed. G. Roberts), Springer. PDF
111. Androsavich, J.R., Chau, B.N., Bhat, B., Linsley, P.S. and Walter, N.G. (2012) Disease-linked microRNA-21 exhibits drastically reduced mRNA binding and silencing activity in healthy mouse liver. RNA. 18, p. 1510-1526. PDF
110. Pitchiaya, S., Androsavich, J.R., and Walter, N.G. (2012) Intracellular single molecule microscopy reveals two kinetically distinct pathways for microRNA assembly. EMBO reports 13, p. 709-715. PDF. Full supplement
109. Michelotti, N., Johnson-Buck, A., Manzo, A.J., M. and Walter, N.G. (2012) Beyond DNA origami: The unfolding prospects of nucleic acid nanotechnology. WIREs: Nanomed Nanobiotechnol. 4, p. 139-152. doi: 10.1002/wnan.170. PDF
108. Eichhorn, C.D., Feng, J., Suddala, K.C., Walter, N.G., Brooks III, C.L. and Al-Hashimi, H.M. (2012) Unraveling the structural complexity in a single stranded RNA tail: Implications for efficient ligand binding in the prequeuosine riboswitch. Nucleic Acids Res. 40, p. 1345-1355. PDF
2011
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107. Sobhy, M.A., Eishenawy, M.M., Takahashi, M., Whitman, B.H., Walter, N.G., Hamdan,S.M. (2011) Versatile single-molecule multi-color excitation and detection fluorescence setup for studying biomolecular dynamics. Rev. Sci. Instrum. 82, p. 113702. PDF
106. Mlynsky, V., Banas, P., Walter, N.G., Sponer, J., Otyepka, M. (2011) QM/MM studies of hairpin ribozyme self-cleavage suggest the feasibility of multiple competing reaction mechanisms. J. Phys. Chem. B 115, p. 13911-13924. PDF
105. Spano, M.N. and Walter, N.G. (2011) Solution structure of an alternate conformation of Helix 27 from Escherichia Coli 16S rRNA. Biopolymers 95, p. 653-668. PDF
104. Marek, M.S., Johnson-Buck, A. and Walter, N.G. (2011) The shape-shifting quasispecies of RNA: one sequence, many functional folds. Phys. Chem. Chem. Phys. 13, p. 11524-11537. PDF
103. Hoerter, J.A.H., Krishnan, V., Lionberger, T.A. and Walter, N.G. (2011) siRNA-like double-stranded RNAs are specifically protected against degradation in human cell extract. PLoS ONE 6, e20359. PDF
102. Johnson-Buck, A.E., McDowell, S.E. and Walter, N.G. (2011) Metal ions: Supporting actors in the playbook of small ribozymes. Met. Ions Life Sci. 9, p. 175-196. PDF
101. Langelier, S.M., Livak-Dahl, E., Manzo, A.J., Johnson, B.N., Walter, N.G., Burns, M.A. (2011) Flexible casting of modular self-aligning microfluidic assembly blocks. Lab Chip 11, p. 1679-1687. PDF. Supplement
100. Rawlings, R.A., Krishnan, V., Walter, N.G. (2011) Viral RNAi suppressor reversibly binds siRNA to outcompete dicer and RISC via multiple turnover.J. Mol. Biol. 408, p. 262-276. PDF. Supplement
99. Feng, J., Walter, N.G., Brooks, C.L. III. (2011) Cooperative and directional folding of the preQ1 riboswitch aptamer domain. J. Am. Chem. Soc. 133, p. 4196-4199. PDF
98. Walter, N.G. (2011) Motor myosin V caught on video: Foot stomping in biology. Biopolymers 95, V. PDF
2010
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97. McDowell, S.E., Jun, J.M., and Walter, N.G. (2010) Long-range tertiary interactions in single hammerhead ribozymes bias motional sampling toward catalytically active conformations. RNA 16, p. 2414-2426. PDF
96. Pereira, M.J.B., Behera, V. and Walter, N.G. (2010) Nondenaturing purification of co-transcriptionally folded RNA avoids common folding heterogeneity. PLoS ONE 5, e12953. PDF
95. Michelotti, N., de Silva, C., Johnson-Buck, A.E., Manzo, A.J., Walter, N.G. (2010) A bird’s eye view: tracking slow nanometer-scale movements of single molecular nano-assemblies. Methods Enzymol. 475, p. 121-148. PDF
94. Banas, P., Walter, N.G., Sponer, J. and Otyepka, M. (2010) Protonation states of the key active site residues and structural dynamics of the glmS riboswitch as revealed by molecular dynamics. J. Phys. Chem. B 114, p. 8701-8712. PDF
93. Hsieh, J., Koutmou, K.s., Rueda, D., Koutmos, M., Walter, N.G., Fierke, C.A. (2010) A divalent cation stabilizes the active conformation of the B. subtilisRNase P-pre-tRNA complex: A role for an inner-sphere metal ion in RNase P. J. Mol. Biol. 400, p. 38-51. PDF
92. Mlynsky, V., Banas, P., Hollas, D., Reblova, K., Walter, N.G., Sponer, J., and Otyepka, M. (2010) Extensive molecular dynamics simulations showing that canonical G8 and protonated A38H+ forms are most consistent with crystal structures of hairpin ribozyme. J. Phys. Chem. B 114, p. 6642-6652. PDF
91. Blanco, M., Walter, N.G. (2010) Analysis of complex single-molecule FRET time trajectories. Methods Enzymol. 472, p. 154-176. PDF
90. Walter, N.G. (2010) Preface. Methods Enzymol. 472, p. xxi-xxii. PDF
89. Lund, K., Manzo, A.J., Dabby, N., Michelotti, N., Johnson-Buck, A., Nangreave, J., Taylor, S., Pei, Stojanovic, M.N., Walter, N.G., Winfree, E., and Yan, H. (2010) Molecular robots guided by prescriptive landscapes. Nature 465, p. 206-210. PDF. Supplement. See reference on the cover. Highlighted in Nature News and Views.
88. Abelson, J., Blanco, M., Ditzler, M.A., Fuller, F., Aravamudhan, P., Wood, M., Villa, T., Ryan, D.E., Pleiss, J.A., Maeder, C., Guthrie, C. and Walter, N.G. (2010) Conformational dynamics of single pre-mRNA molecules in spliceosome assembly. Nat. Struct. Mol. Biol. 17, p. 504-512. PDF. Supplement. Highlighted as UM News Release on March 21, 2010. See also Science and Technology of C&E News on March 21, 2011.
87. Ditzler, M.A., Otyepka, M., Sponer, J. and Walter, N.G. (2010) Molecular dynamics and quantum mechanics of RNA: Conformational and chemical change we can believe in. Acc. Chem. Res. 40, p.40-47. PDF
2009
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86. Walter, N.G. (2009) The blessing and curse of RNA dynamics: past, present, and future. Methods 49, p.85-86. PDF
85. Banas, P., Jurecka, P., Walter, N.G., Sponer, J., and Otyepka, M. (2009) Theoretical studies of RNA catalysis: Hybrid QM/MM methods and their comparison with MD and QM. Methods 49, p.202-216. PDF
84. Kuszak, A., Pitchiaya, S., Anand, J.P., Mosberg, H.I., Walter, N.G., and Sunahara, R.K. (2009) Purification and functional reconstitution of monomeric Mu-Opioid receptors. Journal of Biological Chemistry vol. 284, number 39, p.26732-26741. Full text in pdf format. Supplement in pdf format.
83. Gerczei, T., Shah, B.N., Manzo, A.J., Walter, N.G., and Correll, C.C. (2009) RNA chaperones stimulate formation and yield of the U3 snoRNA-pre-rRNA duplexes needed for eukaryotic ribosome biogenesis. J. Mol. Biol. 390, p. 991-1006. Full text in pdf format. Supplement in pdf format.
82. Ditzler, M.A., Sponer, J., and Walter, N.G. (2009) Molecular dynamics suggest multifunctionality of an adenine imino group in acid-base catalysis of the hairpin ribozyme. RNA 15, p. 560-575. PDF. Supplement in pdf format.
81. de Silva, C. and Walter, N.G. (2009) Leakage and slow allostery limit performance of single drug-sensing aptazyme molecules based on the hammerhead ribozyme. RNA 15, p. 76-84. PDF
80. Walter, N.G. and Perumal, S. (2009) The small ribozymes: Common and diverse features observed through the FRET lens. In: Non-Protein Coding RNAs, p. 103-127 (N.G. Walter, S.A. Woodson and R.T. Batey, eds.), Springer Series in Biophysics volume 13, Springer Publishers, Berlin. PDF
2008
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79. Walter, N.G. (2008) Single molecule detection, analysis, and manipulation. Encycl. Anal. Chem. DOI 10.1002/9780470027318.a0213m.pub2, John Wiley & Sons, Ltd., online at http://www.mrw.interscience.wiley.com/eac/. PDF
78. Ditzler, M.A., Rueda, D., Mo, J., Hakansson, K., and Walter, N.G. (2008) A rugged free energy landscape separates multiple functional RNA folds throughout denaturation. Nucleic Acids Res. 36, p. 7088-7099. Full text in pdf format. Highlighted in Science and Technology of C&E News on March 1, 2010, see in pdf format. For more highlights, please see “In the News”.
77. Walter, N.G. (2008) Resolving the pivotal role of argonaut proteins in RNAi. Biopolymers 89, p. IV. PDF
76. Furchak, J.R.W., Yang, P., Jennings, C., Walter, N.G., and Kennedy, R.T. (2008) Assay for glucosamine 6-phosphate using a ligand-activated ribozyme with fluorescence resonance energy transfer or CE-laser-induced fluorescence detection. Anal. Chem. 80, p. 8195-8201. PDF
75. Banas, P., Rulisek, L., Hanosova, V., Svozil, D., Walter, N.G., Sponer, J., and Otyepka, M. (2008) General base catalysis for cleavage by the active-site cytosine of the hepatitis delta virus ribozyme: QM/MM calculations establish chemical feasibility. J. Phys. Chem. B 112, p. 11177-11187. PDF
74. Pereira, M.J.B., Nikolova, E.N., Hiley, S.L, Jaikaran, D., Collins, R.A., and Walter, N.G. (2008) Single VS ribozyme molecules reveal dynamic and hierarchical folding toward catalysis. J. Mol. Biol. 382, p. 496-509. PDF. Supplemental Information.
73. Al-Hashimi, H.M. and Walter, N.G. (2008) RNA dynamics: it is about time. Curr. Opin. Struct. Biol. 18, p. 321-329. PDF
72. Walter, N.G., Huang, C.-Y., Manzo, A.J., and Sobhy, M.A. (2008) Do-it-yourself guide: How to use the modern single-molecule toolkit. Nat. Methods 5, p. 475-489. PDF. Editorial Comments in Nat. Methods 5, p. 457.
71. Gafni, A. and Walter, N.G. (2008) Program review: The interdisciplinary biophysics graduate program at the University of Michigan. Biopolymers 89, p. 256-261. PDF
2007
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70. Walter, N.G. (2007) Ribozyme catalysis revisited: Is water involved? Mol. Cell 28, p. 923-929. PDF
69. Ditzler, M.A., Aleman, E.A., Rueda, D., and Walter, N.G. (2007) Focus on function: Single molecule RNA enzymology. Biopolymers 87, p. 302-316. PDF
68. Hoerter, J.A.H. and Walter, N.G. (2007) Chemical modification resolves the asymmetry of siRNA strand degradation in human blood serum. RNA 13, p. 1887-1893. PDF
67. Liu, S., Bokinsky, G., Walter, N.G., and Zhuang, X. (2007) Dissecting the multi-step reaction pathway of an RNA enzyme by single-molecule kinetic “fingerprinting”. Proc. Natl. Acad. Sci. USA 104, p. 12634-12639. PDF
66. Tinsley, R.A. and Walter, N.G. (2007) Long-range impact of peripheral joining elements on structure and function of the hepatitis delta virus ribozyme.Biol. Chem. 388, p. 705-715. PDF
65. Bobeck, M.J., Rueda, D., Walter, N.G., and Glick, G.D. (2007) Structural modeling of sequence specificity by an autoantibody against single-stranded DNA Biochemistry 46, p. 6753-6765. PDF
64. Sefcikova, J, Krasovska, M.V., Sponer, J., and Walter, N.G. (2007) The genomic HDV ribozyme utilizes a previously unnoticed U-turn motif to accomplish fast site-specific catalysis. Nucleic Acids Res. 35, p. 1933-1946. PDF
63. Tinsley, R.A., Furchak, J.R.W., and Walter, N.G. (2007) Trans-acting glmS catalytic riboswitch: Locked and loaded. RNA 13, p. 468-477. PDF
62. Sefcikova, J., Krasovska, M.V., Spackova, N., Sponer, J., and Walter, N.G. (2007) Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme. Biopolymers 85, p. 392-406. PDF
61. McDowell, S.E., Spackova, N., Sponer, J., and Walter, N.G. (2007) Molecular dynamics simulations of RNA: An in silico single molecule approach. Biopolymers 85, p. 169-184. PDF
60. Walter, N.G., Meiners, J-C, Meyhofer, E., Neubig, R.R., Sunahara, R.K., Perkins, N.C., Steel, D.G., and Swanson, J.A. (2007) Under the microscope: Single molecule symposium at the University of Michigan, 2006. Biopolymers 85, p. 106-114. PDF
59. Walter, N.G. (2007) Future of biomedical sciences: Single molecule microscopy. Biopolymers 85, p. 103-105. PDF
2006
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58. Rhodes, M.M., Reblova, K., Sponer, J., and Walter, N.G. (2006) Trapped water molecules are essential to structural dynamics and function of a ribozyme. Proc. Natl. Acad. Sci. USA 103, p. 13381-13385. PDF. Supplement.
57. Krasovska, M.V., Sefcikova, J., Reblova, K., Schneider, B., Walter, N.G., and Sponer, J. (2006) Cations and hydration in catalytic RNA: Molecular dynamics of the hepatitis delta virus ribozyme. Biophys. J. 91, p. 626-638. PDF. Supplement.
56. Gondert, M.E., Tinsley, R.A., Rueda, D., and Walter, N.G. (2006) Catalytic core structure of the trans-acting HDV ribozyme is subtly influenced by sequence variation outside the core. Biochemistry 45, p. 7563-7573. PDF
55. Lambert, M.N., Vocker, E., Blumberg S., Redemann, S., Gajraj, A., Meiners, J., and Walter, N.G. (2006) Mg2+ induced compaction of single RNA molecules monitored by tethered particle microscopy. Biophys. J. 90, p. 3672-3685. PDF
54. Tinsley, R.A. and Walter, N.G. (2006) Pyrrolo-C as a fluorescent probe for monitoring RNA secondary structure formation. RNA 12, p. 522-529. PDF
53. Rueda, D. and Walter, N.G. (2006) Fluorescent energy transfer readout of an aptazyme-based biosensor. Methods in Mol. Biol. 335, p. 289-310. PDF
52. Walter, N.G. (2006) Michaelis-Menten is dead, long live Michaelis-Menten! Nature Chem. Biol. 2, p. 66-67. PDF
2005
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51. Rueda, D. and Walter, N.G. (2005) Single molecule fluorescence control for nanotechnology. J. Nanosci. Nanotechnol. 5, p. 1990-2000. PDF
50. Rueda, D., Hsieh, J., Day-Storms, J.J., Fierke, C.A., and Walter N.G. (2005) The 5′ leader of precursor tRNAAsp bound to the Bacillus subtilis RNase P holoenzyme has an extended conformation. Biochemistry 44, p. 16130-16139. PDF
49. Lambert, M.N., Hoerter, J.A.H., Pereira M.J.B., and Walter, N.G. (2005) Solution probing of metal ion binding by helix 27 from Escherichia coli 16S rRNA. RNA 11, p. 1688-1700. PDF
48. Krasovska, M.V., Sefcikova, J., Spackova, N., Sponer, J., and Walter, N.G. (2005) Structural dynamics of precursor and product of the RNA enzyme from the hepatitis delta virus as revealed by molecular dynamics simulations. J. Mol. Biol. 351, p. 731-748. PDF
47. Harris, D.A. and Walter, N.G. (2005) Terbium(III) footprinting as a probe of RNA structure and metal-binding sites. In: Handbook of RNA Biochemistry, p. 205-213 (A. Bindereif, R. Hartmann, A. Schön, and E. Westhof, eds.), Wiley-VCH Verlag, Weinheim. PDF
2004
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46. Hoerter, J.A.H., Lambert, M.N., Pereira M.J.B., and Walter, N.G. (2004) Dynamics inherent in helix 27 from Escherichia coli 16S ribosomal RNA.Biochemistry 43, p. 14624-14636. PDF
45. Harris, D.A., Tinsley, R.A., and Walter, N.G. (2004) Terbium-mediated footprinting probes a catalytic conformational switch in the antigenomic hepatitis delta virus ribozyme. J. Mol. Biol. 341, p. 389-403. PDF
44. Tinsley, R.A., Harris, D.A., and Walter, N.G. (2004) Magnesium dependence of the amplified conformational switch in the trans-acting hepatitis delta virus ribozyme. Biochemistry 43, p. 8935-8945. PDF
43. Rueda, D., Bokinsky, G., Rhodes, M.M., Rust, M.J., Zhuang X., and Walter, N.G. (2004) Single-molecule enzymology of RNA: Essential functional groups impact catalysis from a distance. Proc. Natl. Acad. Sci. USA 101, p. 10066-10071. PDF. Supplement.
2003
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42. Uhler, S.A., Cai, D., Man, Y., Figge, C., and Walter, N.G. (2003) RNA degradation in cell extracts: Real-time monitoring by fluorescence resonance energy transfer. J. Am. Chem. Soc. USA 125, p. 14230-14321. PDF. Supplement.
41. Tinsley, R.T., Harris, D.A., and Walter, N.G. (2003) Significant kinetic solvent isotope effects in folding of the catalytic RNA from the hepatitis delta virus. J. Am. Chem. Soc. 125, p. 13972-13973. PDF. Supplement.
40. Rueda, D., Wick, K., McDowell, S.E., and Walter, N.G. (2003) Diffusely bound Mg2+ ions slightly reorient stems I and II of the hammerhead ribozyme to increase the probability of formation of the catalytic core. Biochemistry 42, p. 9924-9936. PDF
39. Bokinsky, G., Rueda, D., Misra, V.K., Rhodes, M.M., Gordus, A., Babcock, H.P., Walter, N.G., and Zhuang, X. (2003) Single-molecule transition-state analysis of RNA folding. Proc. Natl. Acad. Sci. USA 100, p. 9302-9307. PDF. Highlighted in Science Concentrates of C&E News on July 21, 2003, see in PDF format. For more highlights please see “In The News“
38. Harris, D.A., and Walter, N.G. (2003) Probing RNA structure and metal-binding sites using terbium(III) footprinting. Curr. Protocols in Nucleic Acid Chem. Chapter 6.8 pp. 6.8.1-6.8.8. PDF
37. Jeong, S., Sefcikova, J., Tinsley, R.A., Rueda, D., and Walter, N.G. (2003) Trans-acting hepatitis delta virus ribozyme: Catalytic core and gobal structure are dependent on the 5′ substrate sequence. Biochemistry 42, p. 7727-7740. PDF
36. Walter, N.G. (2003) Probing RNA structural dynamics and function by fluorescence resonance energy transfer. Curr. Protocols Nucleic Acid Chem. Chapter 11.10, pp. 11.10.1-11.10.23. PDF
2002
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35. Walter, N.G., and Engelke, D.R. (2002) Ribozymes: Catalytic RNAs that cut things, make things, and do odd and useful jobs. The Biologist 49, p. 199-203. PDF
34. Sekella, P.T, Rueda, D., and Walter, N.G. (2002) A biosensor for theophylline based on fluorescence detection of ligand-induced hammerhead ribozyme cleavage. RNA 8, p. 1242-1252. PDF
33. Harris, D.A., Rueda, D., and Walter, N.G. (2002) Local conformational changes in the catalytic core of the trans-acting hepatitis delta virus ribozyme accompany catalysis. Biochemistry 41, p. 12051-12061. PDF
32. Zhuang, X., Kim, H., Pereira, M.J.B., Babcock, H.P., Walter, N.G., and Chu, S. (2002) Correlating structural dynamics and function in single ribozyme molecules. Science 296, p. 1473-1476. PDF. Supplement.
31. Walter, N.G., Harris, D.A., Pereira, M.J.B., and Rueda, D. (2002) In the fluorescent spotlight: global and local conformational changes of small catalytic RNAs. Biopolymers 61, p. 224-241. PDF
30. Pereira, M.J.B., Harris, D.A., Rueda, D., and Walter, N.G. (2002) Reaction pathway of the trans-acting hepatitis delta virus ribozyme: A conformational change accompanies catalysis. Biochemistry 41, p. 730-740. PDF
2001
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29. Walter, N.G. (2001) Structural dynamics of catalytic RNA highlighted by fluorescence resonance energy transfer. Methods 25, p. 19-30. PDF
28. Todorov, T.I., Carmejane, O., Walter, N.G., and Morris, M.D. (2001) Capillary electrophoresis of RNA in dilute and semi-dilute polymer solutions.Electrophoresis 22,p. 2442-2447. PDF
27. Michael J. Fay, Walter, N.G., and Burke, J.M. (2001) Imaging of single hairpin ribozymes in solution by atomic force microscopy. RNA 7, p. 887-895. PDF
26. Walter, N.G., Chan, P.A., Hampel, K.J., Millar, D.P., and Burke, J.M. (2001) A base change in the catalytic core of the hairpin ribozyme perturbs function but not domain docking. Biochemistry 40, p. 2580-2587. PDF
25. Pinard, R., Lambert, D., Heckman, J.E., Esteban, J.A., Gundlach, C.W., Hampel, K.J., Heckman, J.E., Glick, G.D., Walter, N.G., Major, F., and Burke, J.M. (2001) The hairpin ribozyme substrate binding-domain: A highly constrained D-shaped conformation. J. Mol. Biol. 307, p. 51-65. PDF
2000
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24. Walter, N.G., Yang, N., and Burke, J.M. (2000) Probing non-selective cation binding in the hairpin ribozyme with Tb(III). J. Mol. Biol. 298, p. 539-555. PDF
23. Walter, N.G., and Burke, J.M. (2000) Fluorescence assays to study structure, dynamics, and function in RNA and RNA-ligand complexes. Methods Enzymol. 317, p. 409-440. PDF
1999
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22. Pinard, R., Lambert, D., Walter, N.G., Heckman, J.E., Major, F., and Burke, J.M. (1999) Structural basis for the guanosine requirement of the hairpin ribozyme. Biochemistry 38, p. 16035-16039. PDF
21. Porschke, D., Burke, J.M., and Walter, N.G. (1999) Global structure and flexibility of hairpin ribozymes with extended terminal helices. J. Mol. Biol. 289, p.799-813. PDF
20. Walter, N.G., Burke, J.M., and Millar, D.P. (1999) Stability of hairpin ribozyme tertiary structure is governed by the interdomain junction. Nat. Struct. Biol. 6, p. 544-549. PDF
1998
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19. Ederhof, T., Walter, N.G., and Schober A. (1998) On-line polymerase chain reaction (PCR) monitoring. J. Biochem. Biophys. Meth. 37, p.99-104. PDF
18. Hampel, K.J., Walter, N.G., and Burke, J.M. (1998) The solvent-protected core of the hairpin ribozyme-substrate complex. Biochemistry 37, p.14672-14682. PDF
17. Murray, J.B., Seyhan, A.A., Walter, N.G., Burke, J.M., and Scott, W.G. (1998) The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone. Chem. Biol. 5, p. 587-595. PDF
16. Esteban, J.A., Walter, N.G., Kotzorek, G., Heckman, J.E., and Burke, J.M. (1998) Structural basis for heterogeneous kinetics: Reengineering the hairpin ribozyme. Proc. Natl. Acad. Sci. USA 95, p.6091-6095. PDF
15. Walter, N.G., Hampel, K.J., Brown, K.M., and Burke, J.M. (1998) Tertiary structure formation in the hairpin ribozyme monitored by fluorescence resonance energy transfer. EMBO J. 17, p. 2378-2391. PDF
14. Walter, N.G. and Burke, J.M. (1998) The hairpin ribozyme: structure, assembly and catalysis. Curr. Opin. Chem. Biol. 2, p. 24-30. PDF
1997
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13. Preuss, R., Dapprich, J., and Walter, N.G. (1997) Probing RNA-protein interactions using pyrene-labeled oligodeoxynucleotides: Qb replicase efficiently binds replicable RNAs by recognizing pyrimidine residues. J. Mol. Biol. 273, p.600-613. PDF
12. Walter, N.G., Albinson, E., and Burke, J.M. (1997) Probing structure formation in the hairpin ribozyme using fluorescent substrate analogs. Nucleic Acids Symp. Ser. 36, p. 175-177.
11. Dapprich, J., Walter, N.G., Salingue, F., and Staerk, H. (1997) Base-dependent pyrene fluorescence used for in-solution detection of nucleic acids. In Proceedings of the 4th International Conference on Methods and Applications of Fluorescence Spectroscopy (D. Birch and J. Miller, eds.). J. Fluorescence 7, p. 87S-89S.
10. Walter, N.G., and Burke, J.M. (1997) Real-time monitoring of hairpin ribozyme kinetics through base-specific quenching of fluorescein-labeled substrates. RNA 3, p. 392-404. PDF
1996
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9. Walter, N.G., Schwille, P., and Eigen, M. (1996) Fluorescence correlation analysis of probe diffusion simplifies quantitative pathogen detection by PCR.Proc. Natl. Acad. Sci. USA 93, p. 12805-12810. PDF
8. Schwille, P., Oehlenschlaeger, F., and Walter, N.G. (1996) Quantitative hybridization kinetics of DNA probes to RNA in solution followed by diffusional fluorescence correlation spectroscopy. Biochemistry 35, p.10182-10193. PDF
1995
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7. Walter, N.G. (1995) Modelling viral evolution in vitro using exo- Klenow polymerase: Continuous selection of strand displacement amplified DNA that binds an oligodeoxynucleotide to form a triple-helix. J. Mol. Biol. 254, p. 856-868. PDF
6. Walter, N. (1995) Untersuchung molekularer in vitro-Evolution mit Hilfe nicht-radioaktiver Detektion von Nukleinsaeuren. Cuvillier Verlag, Goettingen.
5. Schober, A., Walter, N.G., Tangen, U., Strunk, G., Ederhof, T., Dapprich J., and Eigen, M. (1995) A multichannel PCR and serial transfer machine as a future tool in evolutionary biotechnology. Biotechniques 18, p.652-660. PDF
1994
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4. Walter, N.G., and Steiner, C. (1994) Screening for polymerase activities by fast quantification of chemiluminescent dot blot membranes using a filter adapter in a photon counting microplate luminometer. In Bioluminescence and Chemiluminescence: Fundamentals and Applied Aspects. (A. Campbell, L. Kricka and P. Stanley, eds.), John Wiley & Sons, Chichester pp. 83-86. PDF
3. Walter, N.G., and Strunk, G. (1994) Strand displacement amplification as an in vitro model for rolling-circle replication: Deletion formation and evolution during serial transfer. Proc. Natl. Acad. Sci. USA 91, p.7937-7941. PDF
2. Walter, N.G., and Steiner, C. (1994) Fast quantification of chemiluminescent dot blot membranes using a filter adapter in a microplate luminometer: Application to polymerase activity assays. J. Biolum. Chemilum. 9, 302.
1993
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1. Walter, N., and Steiner, C. (1993) Fast chemiluminescent measurement of T7 RNA polymerase activity based on photon counting technology. Biotechniques 12, p.926-931. PDF
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Biochemistry
JACS
Science
Nature
Proc. Natl. Acad. Sci USA
J. Mol. Biol.